This article presents and analyses wholesale price series of Santa Fe (Argentina), an essential core of colonial commercial circuits, during the period 1700-1810. Mainly from monastic sources, the presented series include 14 products from local and regional origin. Production data has also been deflated using these indexes and purchasing power of wages has been measured. This allows studying inflation, deflation and standards of living and their relation to economic growth. Growth, even prior to trade liberalization of 1778, was matched by deflation so it may suggest improvements in mercantile circuits. This new evidence provides a solid tool for regional and international comparative analysis.