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Volume 164 - February 1994

Contents

Page 1 of 17

Editorials

  • Panic and Suicidal Behaviour: Risk of self-harm in patients who complain of panic

  • Louis Appleby
  • Published online by Cambridge University Press:
    02 January 2018, pp. 719-721
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  • The British Journal of Psychiatry: Achieving Excellence

  • Greg Wilkinson
  • Published online by Cambridge University Press:
    02 January 2018, p. 1
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  • The New Atypical Antipsychotics: A lack of extrapyramidal side-effects and new routes in schizophrenia research

  • R. W. Kerwin
  • Published online by Cambridge University Press:
    02 January 2018, pp. 141-148
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Other

Editorial

  • The Use of Higher-Dose Antipsychotic Medication: Comment on the Royal College of Psychiatrists' consensus statement

  • John M. Kane
  • Published online by Cambridge University Press:
    02 January 2018, pp. 431-432
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Editorials

  • Biological and Hormonal Aspects of Postpartum Depressed Mood: Working Towards Strategies for Prophylaxis and Treatment

  • Brian Harris
  • Published online by Cambridge University Press:
    02 January 2018, pp. 288-292
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  • Psychiatric Assessment at the Magistrates' Court: Early intervention is needed in the remand process

  • Philip L. A. Joseph
  • Published online by Cambridge University Press:
    02 January 2018, pp. 722-724
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Editorial

Introduction

Editorials

  • Prenatal Exposure to Influenza as a Cause of Schizophrenia: There are inconsistencies and contradictions in the evidence

  • T. J. Crow
  • Published online by Cambridge University Press:
    02 January 2018, pp. 588-592
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  • Genetics of Alzheimer's Disease: Some molecular understanding of a diverse phenotype

  • David St Clair
  • Published online by Cambridge University Press:
    02 January 2018, pp. 153-156
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Editorial

  • Homosexual Orientation: The search for a biological basis

  • John Bancroft
  • Published online by Cambridge University Press:
    02 January 2018, pp. 437-440
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I. The Theory of Schizophrenia

  • Biological Factors in Schizophrenia Structural and Functional Aspects

  • E. K. G. Syvälahti
  • Published online by Cambridge University Press:
    06 August 2018, pp. 9-14

  • A number of factors have been proposed as being linked to schizophrenia: genetic, psychological, endocrinological, metabolic, environmental, virological, and auto-immunological factors, as well as neurotransmitter systems and structural disorders of the brain. All may act as predisposing, triggering, or functionally modulating factors in what is probably a condition composed of several types of disorder with varying aetiology. Neuroanatomical and neuromorphological data have revealed ventricular enlargement and diminished frontal and temporal lobe volume in some patients. These changes are concentrated particularly in the hippocampus/parahippocampal gyrus/amygdala, but are relatively small and span some overlap with healthy subjects. Twin studies suggest that at least some of these changes may result from other than genetic factors. Functional disturbances of the brain have also been connected with frontal and temporal structures in some schizophrenic patients. Of the single neurotransmitter substances, dopamine and serotonin appear to represent some of the central restitutive mechanisms whose function is to maintain mental stability; the understanding of their interplay with other neurotransmitters such as noradrenaline, acetylcholine, GABA, and glutamate, should provide a more integrated view of both normal and disturbed brain function.

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