This article examines the origins and dynamics of Aberewa, an anti-witchcraft movement that rose to prominence in the Akan forest region of Asante and the Gold Coast (Ghana) in 1906–10. It suggests that while the political, social and economic changes of the early colonial period acted as a catalyst for its widespread expansion, Aberewa emerged from an earlier cult called Sakrabundi that was already moving from the savanna into the northern reaches of the Asante empire by the 1880s. The ritual trajectory and popular appeal of Sakrabundi and Aberewa are explored within the context of the ambivalent relationship between the Akan peoples and their northern savanna neighbours. An argument is made for the need to consider witchcraft and anti-witchcraft in Africa as historical processes rather than as a set of structural beliefs and practices.