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Chapter 3 - Meiosis: How to Get a Good Start in Life

Published online by Cambridge University Press:  15 December 2022

By
Ursula Eichenlaub-Ritter
Edited by
Stéphane Viville  and
Karen D. Sermon
Stéphane Viville
Affiliation:
Laboratoire de Génétique Médicale de Strasbourg and Laboratoire de diagnostic génétique, Strasbourg
Karen D. Sermon
Affiliation:
Reproduction and Genetics Research Group, Vrije Universiteit Brussel
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Summary

Meiosis comprises fundamental processes that permit sexual reproduction and species evolution. In addition to producing haploid gametes, it provides for a stochastic distribution of maternally and paternally inherited chromosomes, which undergo allelic recombination thereby increasing genetic variability in the next generation. Thus it provides for diversity within a population, and is essential for the formation of euploid germ cells that will contribute to a euploid healthy embryo after fertilization. Meiosis is therefore the basis for maintaining genomic integrity, high developmental potential, and health of the embryo and offspring, and normal fertility in males and females [1,2]. Furthermore, it is the basis of changes in the genome that are important for adaptation and evolution of species.

Type
Chapter
Information
Textbook of Human Reproductive Genetics , pp. 31 - 47
Publisher: Cambridge University Press
Print publication year: 2023

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References

Alberts, B, Johnson, A, Lewis, J, et al. (eds.) Meiosis. In Molecular Biology of the Cell, 4th ed. New York: Garland Science, 2002.Google Scholar
Bolcun-Filas, E, Handel, MA. Meiosis: the chromosomal foundation of reproduction. Biol Reprod 2018;99(1):112–26.CrossRefGoogle ScholarPubMed
Ishiguro, K. The cohesin complex in mammalian meiosis. Genes Cells 2019;24(1):6–30.CrossRefGoogle ScholarPubMed
Greaney, J, Wei, Z, Homer, H. Regulation of chromosome segregation in oocytes and the cellular basis for female meiotic errors.Hum Reprod Update 2018;24(2):135–61.CrossRefGoogle ScholarPubMed
Gray, S, Cohen, PE. Control of meiotic crossovers: from double-strand break formation to designation.Annu Rev Genet 2016;50:175–210.CrossRefGoogle ScholarPubMed
Dunne, OM, Davies, OR. Molecular structure of human synaptonemal complex protein SYCE1. Chromosoma 2019;128(3):223–36.CrossRefGoogle ScholarPubMed
Hassold, T, Sherman, S, Hunt, P. Counting cross-overs: characterizing meiotic recombination in mammals. Hum Mol Genet 2000;9(16):2409–19.CrossRefGoogle ScholarPubMed
Poriswanish, N, Neumann, R, Wetton, JH, et al. Recombination hotspots in an extended human pseudoautosomal domain predicted from double-strand break maps and characterized by sperm-based crossover analysis. PLoS Genet 2018;4(10):e1007680.Google Scholar
Ottolini, CS, Newnham, L, Capalbo, A, et al. Genome-wide maps of recombination and chromosome segregation in human oocytes and embryos show selection for maternal recombination rates. Nat Genet 2015;47(7):727–35.CrossRefGoogle ScholarPubMed
Handyside, AH, Montag, M, Magli, MC, et al. Multiple meiotic errors caused by predivision of chromatids in women of advanced maternal age undergoing in vitro fertilisation. Eur J Hum Genet 2012;20:742–7.CrossRefGoogle ScholarPubMed
Ottolini, CS, Capalbo, A, Newnham, L, et al. Generation of meiomaps of genome-wide recombination and chromosome segregation in human oocytes. Nat Protoc 2016;11:1229–43.CrossRefGoogle ScholarPubMed
Kong, A, Thorleifsson, G, Gudbjartsson, DF, et al. Fine-scale recombination rate differences between sexes, populations and individuals. Nature 2010;467(7319):1099–103.Google Scholar
Baudat, F, Imai, Y, De Massy, B. Meiotic recombination in mammals: localization and regulation. Nat Rev Genet 2013;14(11):794–806.CrossRefGoogle ScholarPubMed
Manhart, CM, Alani, E. Roles for mismatch repair family proteins in promoting meiotic crossing over. DNA Repair (Amst) 2016;38: 84–93.Google Scholar
Gruhn, JR, Zielinska, AP, Shukla, V, et al. Chromosome errors in human eggs shape natural fertility over reproductive life span. Science 2019;365(6460):1466–9.Google Scholar
Capalbo, A, Hoffmann, ER, Cimadomo, D, Ubaldi, FM, Rienzi, L. Human female meiosis revised: new insights into the mechanisms of chromosome segregation and aneuploidies from advanced genomics and time-lapse imaging. Hum Reprod Update 2017;23(6):706–22.CrossRefGoogle ScholarPubMed
Nambiar, M, Smith, GR. Pericentromere-specific cohesin complex prevents meiotic pericentric DNA double-strand breaks and lethal crossovers. Mol Cell 2018;71(4):540–53.e4.CrossRefGoogle ScholarPubMed
Wang, S, Hassold, T, Hunt, P, et al. Inefficient crossover maturation underlies elevated aneuploidy in human female meiosis.Cell 2017;168(6):977–89.e17.Google Scholar
Hattori, A, Fukami, M. Established and novel mechanisms leading to de novo genomic rearrangements in the human germline. Cytogenet Genome Res 2020;160(40):167–76. DOI 10.1159/000507837Google Scholar
Eichenlaub-Ritter, U. Oocyte ageing and its cellular basis. Int J Dev Biol 2012;56(10–12):841–52.CrossRefGoogle ScholarPubMed
Lane, S, Kauppi, L. Meiotic spindle assembly checkpoint and aneuploidy in males versus females.Cell Mol Life Sci 2019;76(6):1135–50.Google Scholar
Mogessie, B, Scheffler, K, Schuh, M. Assembly and positioning of the oocyte meiotic spindle. Annu Rev Cell Dev Biol 2018;34:381–403.CrossRefGoogle ScholarPubMed
Colaco, S, Sakkas, D. Paternal factors contributing to embryo quality. J Assist Reprod Genet 2018;35(11):1953–68.Google Scholar
Machev, N, Gosset, P, Warter, S, et al. Fluorescence in situ hybridization sperm analysis of six translocation carriers provides evidences of an interchromosomal effect. Fertil Steril 2005;84:365–73.Google Scholar
Mateu-Brull, E, Rodrigo, L, Peinado, V, et al. Interchromosomal effect in carriers of translocations and inversions assessed by preimplantation genetic testing for structural rearrangements (PGT-SR). Assist Reprod Genet 2019;36(12):2547–55.CrossRefGoogle ScholarPubMed
Nicholls, PK, Schorle, H, Naqvi, S, et al. Mammalian germ cells are determined after PGC colonization of the nascent gonad. Proc Natl Acad Sci USA 2019;116(51):25677–87.Google Scholar
Spiller, C, Koopman, P, Bowles, J. Sex determination in the mammalian germline. Annu Rev Genet 2017;51:265–85.CrossRefGoogle ScholarPubMed
Conti, M, Franciosi, F. Acquisition of oocyte competence to develop as an embryo: integrated nuclear and cytoplasmic events. Hum Reprod Update 2018;24(3):245–66.CrossRefGoogle ScholarPubMed
Richani, D, Dunning, KR, Thompson, JG, Gilchrist, RB. Metabolic co-dependence of the oocyte and cumulus cells: essential role in determining oocyte developmental competence. Hum Reprod Update 2021;27(1):27–47.CrossRefGoogle ScholarPubMed
Veitia, RA. Primary ovarian insufficiency, meiosis and DNA repair. Biomed J 2020;43(2):115–23.Google Scholar
Zielinska, AP, Bellou, E, Sharma, N, et al. Meiotic kinetochores fragment into multiple lobes upon cohesin loss in aging eggs. Curr Biol 2019;29(22):3749–65.e7.Google Scholar
Pacchierotti, F, Eichenlaub-Ritter, U. Environmental hazard in the aetiology of somatic and germ cell aneuploidy. Cytogenet Genome Res 2011;133(2–4):254–68.Google Scholar
Harper, JC, Aittomäki, K, Borry, P, et al. Recent developments in genetics and medically assisted reproduction: from research to clinical applications. Hum Reprod Open 2017;2017(3):hox015.Google Scholar
Veller, C, Kleckner, N, Nowak, MA. A rigorous measure of genome-wide genetic shuffling that takes into account crossover positions and Mendel’s second law. Proc Natl Acad Sci USA 2019;116(5):1659–68.Google Scholar

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