Book contents
- Textbook of Human Reproductive Genetics
- Textbook of Human Reproductive Genetics
- Copyright page
- Contents
- Contributors
- Chapter 1 Basic Genetics and Cytogenetics: A Brief Reminder
- Chapter 2 Application of Whole-Genome Technologies to Assisted Reproductive Treatment
- Chapter 3 Meiosis: How to Get a Good Start in Life
- Chapter 4 Chromosomes in Early Human Embryo Development: Incidence of Chromosomal Abnormalities, Underlying Mechanisms, and Consequences for Diagnosis and Development
- Chapter 5 DNA Is Not the Whole Story: Transgenerational Epigenesis and Imprinting
- Chapter 6 Genes Are Not the Whole Story: Retrotransposons as New Determinants of Male Fertility
- Chapter 7 Chromosomal Causes of Infertility
- Chapter 8 Genetics of Human Male Infertility: The Quest for Diagnosis and Treatment
- Chapter 9 Genetics of Human Female Infertility
- Chapter 10 Preconception Genetics Analysis/Screening in IVF
- Chapter 11 Genetic Counseling in Assisted Reproductive Treatment
- Chapter 12 Mitochondrial Genetics in Reproductive Medicine
- Chapter 13 Preimplantation Genetic Testing
- Chapter 14 Epigenetics and Assisted Reproductive Technology
- Chapter 15 Human Reproductive Genetics in Medically Assisted Reproduction: Ethical Considerations
- Index
- References
Chapter 4 - Chromosomes in Early Human Embryo Development: Incidence of Chromosomal Abnormalities, Underlying Mechanisms, and Consequences for Diagnosis and Development
Published online by Cambridge University Press: 15 December 2022
- Textbook of Human Reproductive Genetics
- Textbook of Human Reproductive Genetics
- Copyright page
- Contents
- Contributors
- Chapter 1 Basic Genetics and Cytogenetics: A Brief Reminder
- Chapter 2 Application of Whole-Genome Technologies to Assisted Reproductive Treatment
- Chapter 3 Meiosis: How to Get a Good Start in Life
- Chapter 4 Chromosomes in Early Human Embryo Development: Incidence of Chromosomal Abnormalities, Underlying Mechanisms, and Consequences for Diagnosis and Development
- Chapter 5 DNA Is Not the Whole Story: Transgenerational Epigenesis and Imprinting
- Chapter 6 Genes Are Not the Whole Story: Retrotransposons as New Determinants of Male Fertility
- Chapter 7 Chromosomal Causes of Infertility
- Chapter 8 Genetics of Human Male Infertility: The Quest for Diagnosis and Treatment
- Chapter 9 Genetics of Human Female Infertility
- Chapter 10 Preconception Genetics Analysis/Screening in IVF
- Chapter 11 Genetic Counseling in Assisted Reproductive Treatment
- Chapter 12 Mitochondrial Genetics in Reproductive Medicine
- Chapter 13 Preimplantation Genetic Testing
- Chapter 14 Epigenetics and Assisted Reproductive Technology
- Chapter 15 Human Reproductive Genetics in Medically Assisted Reproduction: Ethical Considerations
- Index
- References
Summary
Reproduction in humans is considered to be a relatively inefficient process, as the chance of achieving a spontaneous pregnancy after timed intercourse is only approximately 30%. This is much lower than the 70–90% estimated for other species, such as the rhesus monkey, the captive baboon, or rodents and rabbits. The inefficiency of human reproduction is mainly explained by the high incidence of preclinical losses, an estimated 40–60% of all conceptions. Early pregnancy loss is mainly explained due to the occurrence of chromosome abnormalities, which have been identified in most spontaneous abortion samples investigated.
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- Textbook of Human Reproductive Genetics , pp. 48 - 67Publisher: Cambridge University PressPrint publication year: 2023