Lank, P, Pines, E, Mycyk, M. Emergency physicians’ knowledge of cannabinoid designer drugs. West J Emerg Med 2013;14:467–470.CrossRefGoogle ScholarPubMed

Ramos C, , Guirguis A, , Smeeton N, et al. Exploring the baseline knowledge and experience of healthcare professionals in the United Kingdom on novel psychoactive substances. Brain Sci 2020;10:142. https://doi.org/10.3390/brainsci10030142CrossRefGoogle Scholar

United Nations Office on Drugs and Crime (UNODC). Early Warning Advisory on New Psychoactive Substances. www.unodc.org/LSS/Page/NPS [last accessed 9 February 2022].Google Scholar

United Nations Office on Drugs and Crime (UNODC). Global SMART Update Understanding the Synthetic Drug Market: The NPS Factor. Volume 19, March. Appears to be missing the yearGoogle Scholar

The EU Action against Drugs and Organised Crime (EU-ACT) funded by the European Commission and implemented by FIIAPP.Google Scholar

World Health Organization (WHO) and United Nations Office on Drugs and Crime (UNODC). International standards for the treatment of drug use disorders: revised edition incorporating results of field-testing. Geneva, 2020. License: CC BY-NC-SA 3.0 IGO.Google Scholar

European Monitoring Centre for Drugs and Drug Addiction. Action framework for developing and implementing health and social responses to drug problems. Available from: www.emcdda.europa.eu/printpdf/publications/mini-guides/action-framework-for-developing-and-implementing-health-and-social-responses-to-drug-problems_enGoogle Scholar

The World Health Organization has developed guidance and training materials on poisons centres. For more information see: https://apps.who.int/iris/handle/10665/331635; www.unodc.org/documents/drug-prevention-and-treatment/UNODC-WHO_International_Standards_Treatment_Drug_Use_Disorders_April_2020.pdf. For a directory of poisons centres, see: www.who.int/gho/phe/chemical_safety/poisons_centres/en/.Google Scholar

Lingford-Hughes, AR, Welch, S, Peters, L, Nutt, DJ; British Association for Psychopharmacology, Expert Reviewers Group. BAP updated guidelines: evidence-based guidelines for the pharmacological management of substance abuse, harmful use, addiction and comorbidity: recommendations from BAP. J Psychopharmacol 2012;26(7):899–952. https://doi.org/10.1177/0269881112444324Google Scholar

See e.g. Santos-Toscano R, , Guirguis A, , Davidson D., How preclinical studies have influenced novel psychoactive substance legislation in the UK and Europe. Br J Clin Pharmacol, Special Issue: New Psychoactive Substances 2020;86(3):452–481.Google Scholar

Peacock A, , Bruno R, , Gisev N, et al. New psychoactive substances: challenges for drug surveillance, control, and public health responses. Lancet 2019;394:1668–1684.CrossRefGoogle Scholar

United Nations Office on Drugs and Crime (UNODC). The Challenge of New Psychoactive Substances. Global SMART Programme 2013.Google Scholar

United Nations Office on Drugs and Crime (UNODC). Global SMART Update Understanding the Synthetic Drug Market: The NPS Factor, Volume 19.Google Scholar

United Nations Office on Drugs and Crime (UNODC). World Drug Report 2014.Google Scholar

World Drug Report 2021 (United Nations publication, Sales No. E.21.XI.8).Google Scholar

United Nations Office on Drugs and Crime (UNODC). Early Warning Advisory on New Psychoactive Substances. www.unodc.org/LSS/Announcement?type=NPS [last accessed 21 February 2022].Google Scholar

European Monitoring Centre for Drugs and Drug Addiction (2021), European Drug Report 2021: Trends and Developments, Publications Office of the European Union, LuxembourgGoogle Scholar

Corkery, JM, Guirguis, A, Papanti, DG, Orsolini, L, Schifano, F. Synthetic cathinones: prevalence and motivations for use. In: Zawilska, J (ed.), Synthetic Cathinones: Current Topics in Neurotoxicity, volume 12. Springer, Cham, 2018.Google Scholar

World Drug Report 2021 (United Nations publication, Sales No. E.21.XI.8).Google Scholar

World Drug Report 2020 (United Nations publication, Sales No. E.20.XI.6).Google Scholar

The United Nations Office on Drugs and Crime (UNODC) World Drug Report 2019 (United Nations publication, Sales No. E.19.XI.8). Available at: https://wdr.unodc.org/wdr2019/prelaunch/WDR19_Booklet_1_EXECUTIVE_SUMMARY.pdf [last accessed 15 February 2022].Google Scholar

European Monitoring Centre for Drugs and Drug Addiction and Europol. EU Drug Markets Report: In-Depth Analysis, EMCDDA–Europol Joint publications. Publications Office of the European Union, Luxembourg, 2016.Google Scholar

Reuter, P. Options for Regulating New Psychoactive Drugs: A Review of Recent Experiences. UK Drug Policy Commission (UKDPC), 2011.Google Scholar

McNabb, CB, Russell, BR, Caprioli, D, Nutt, DJ, Gibbons, S, Dalley, JW. Single chemical entity legal highs: assessing the risk for long term harm. Curr Drug Abuse Rev 2012;5(4):304–319.Google Scholar

Peters, FT, Martinez-Ramirez, JA. Analytical toxicology of emerging drugs of abuse. Ther Drug Monit 2010;32(5):532–539. https://doi.org/10.1097/FTD.0b013e3181f33411Google Scholar

Maurer, HH. Chemistry, pharmacology, and metabolism of emerging drugs of abuse. Ther Drug Monit 2010;32(5):544–549. https://doi.org/10.1097/FTD.0b013e3181eea318Google Scholar

United Nations Office on Drugs and Crime (UNODC). The Challenge of New Psychoactive Substances. Global SMART Programme 2013.Google Scholar

United Nations Office on Drugs and Crime (UNODC). Early Warning Advisory on New Psychoactive Substances. www.unodc.org/LSS/Page/NPS [last accessed 9 February 2022].Google Scholar

United Nations Office on Drugs and Crime (UNODC). Early Warning Advisory on New Psychoactive Substances. www.unodc.org/LSS/Page/NPS [last accessed 9 February 2022].Google Scholar

European Monitoring Centre for Drugs and Drug Addiction. European Drug Report 2019: Trends and Developments. Publications Office of the European Union, Luxembourg, 2019.Google Scholar

European Monitoring Centre for Drugs and Drug Addiction. European Drug Report 2017: Trends and Developments. Publications Office of the European Union, Luxembourg, 2017.Google Scholar

European Monitoring Centre for Drugs and Drug Addiction. European Drug Report 2019: Trends and Developments. Publications Office of the European Union, Luxembourg, 2019.Google Scholar

Home Office. Review of the Psychoactive Substances Act 2016. Available from: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/756896/Review_of_the_Psychoactive_Substances_Act__2016___web_.pdfGoogle Scholar

European Monitoring Centre for Drugs and Drug Addiction. European Drug Report 2017: Trends and Developments. Publications Office of the European Union, Luxembourg, 2017.Google Scholar

Tanibuchi, Y, Matsumoto, T, Shimane, T, Funada, D. The influence of tightening regulations on patients with new psychoactive substance-related disorders in Japan. Neuropsychopharmacol Rep 2018;38(4):189–196. https://doi.org/10.1002/npr2.12035Google Scholar

The United Nations Office on Drugs and Crime (UNODC). World Drug Report 2019 (United Nations publication, Sales No. E.19.XI.8). Available at: https://wdr.unodc.org/wdr2019/prelaunch/WDR19_Booklet_1_EXECUTIVE_SUMMARY.pdfGoogle Scholar

European Monitoring Centre for Drugs and Drug Addiction. European Drug Report 2019: Trends and Developments. Publications Office of the European Union, Luxembourg, 2019.Google Scholar

European Monitoring Centre for Drugs and Drug Addiction. Fentanils and synthetic cannabinoids: driving greater complexity into the drug situation. An update from the EU Early Warning System (June 2018). Publications Office of the European Union, Luxembourg, 2018.Google Scholar

www.unodc.org/LSS/announcement/Details/4977098d-62f0-4966-a23e-4eaab99c0dfc [last accessed 9 February 2022].Google Scholar

World Drug Report 2019 (United Nations publication, Sales No. E.19.XI.8).Google Scholar

European Monitoring Centre for Drugs and Drug Addiction European Drug Report 2021: Trends and Developments, Publications Office of the European Union, Luxembourg. 2021Google Scholar

Measham, F, Moore, K, Newcombe, R, & Welch, Z. Tweaking, bombing, dabbing and stockpiling: the emergence of mephedrone and the perversity of prohibition. Drugs and Alcohol Today 2010;10(1):14–21.Google Scholar

Corazza, O, Simonato, P, Corkery, J, Trincas, G, & Schifano, F. ‘Legal highs’: safe and legal ‘heavens’? A study on the diffusion, knowledge and risk awareness of novel psychoactive drugs among students in the UK. Rivista Di Psichiatria 2014;49(2):89–94. https://doi.org/10.1708/1461.16147Google Scholar

Sande, M. Characteristics of the use of 3-MMC and other new psychoactive drugs in Slovenia, and the perceived problems experienced by users. Int J Drug Policy 2016;27:65–73. https://doi.org/10.1016/j.drugpo.2015.03.005CrossRefGoogle ScholarPubMed

Winstock, AR, Lawn, W, Deluca, P, Borschmann, R. Methoxetamine: an early report on the motivations for use, effect profile and prevalence of use in a UK clubbing sample. Drug Alcohol Rev 2016;35(2):212–217. https://doi.org/10.1111/dar.12259CrossRefGoogle Scholar

Measham, F, Moore, K, Newcombe, R, Welch, Z. Tweaking, bombing, dabbing and stockpiling: the emergence of mephedrone and the perversity of prohibition. Drugs Alcohol Today 2010;10(1):14–21. https://doi.org/10.5042/daat.2010.0123Google Scholar

Soussan C, , Andersson M, , Kjellgren A. The diverse reasons for using novel psychoactive substances: a qualitative study of the users’ own perspectives. Int J Drug Policy 2018;52:71–78.Google Scholar

Benschop, A, Urbán, R, Kapitány-Fövény, M, et al. Why do people use new psychoactive substances? Development of a new measurement tool in six European countries. J Psychopharmacol 2020;34(6):600–611. https://doi.org/10.1177/0269881120904951Google Scholar

Corazza, O, Simonato, P, Corkery, J, Trincas, G, Schifano, F. Legal highs: safe and legal heavens? A study on the diffusion, knowledge and risk awareness of novel psychoactive drugs among students in the UK. Rivista Di Psichiatria 2014;49(2):89–94. http://dx.doi.org/10.1708/1461.16147Google Scholar

Johnson, LA, Johnson, RL, Portier, RB. Current legal highs. J Emerg Med 2013;44(6):1108–1115. http://dx.doi.org/10.1016/j.jemermed.2012.09.147Google Scholar

Measham, F, Moore, K, Newcombe, R, Welch, Z. Tweaking, bombing, dabbing and stockpiling: the emergence of mephedrone and the perversity of prohibition. Drugs Alcohol Today 2010;10(1):14–21. http://dx.doi.org/10.5042/daat.2010.0123CrossRefGoogle Scholar

Sande, M. Characteristics of the use of 3-MMC and other new psychoactive drugs in Slovenia, and the perceived problems experienced by users. Int J Drug Policy 2016;27:65–73. http://dx.doi.org/10.1016/j.drugpo.2015.03.005CrossRefGoogle ScholarPubMed

Werse, B, Morgenstern, C. How to handle legal highs? Findings from a German online survey and considerations on drug policy issues. Drugs Alcohol Today 2012;12(4):222–231. http://dx.doi.org/10.1108/17459261211286636Google Scholar

Winstock, AR, Lawn, W, Deluca, P, Borschmann, R. Methoxetamine: an early report on the motivations for use, effect profile and prevalence of use in a UK clubbing sample. Drug Alcohol Rev 2016;35:212–217. https://doi.org/10.1111/darCrossRefGoogle Scholar

Maxwella S, , Shahmanesh M, , Gafos M. Chemsex behaviours among men who have sex with men: a systematic review of the literature. Int J Drug Policy 2019;63:74–89.Google Scholar

Soussan C, , Andersson M, , Kjellgren, A. The diverse reasons for using novel psychoactive substances: a qualitative study of the users’ own perspectives. Int J Drug Policy 2018;52:71–78.Google Scholar

Soussan, C, Kjellgren, A. The users of novel psychoactive substances: online survey about their characteristics, attitudes and motivations. Int J Drug Policy 2016;32:77–84. http://dx.doi.org/10.1016/j.drugpo.2016.03.007Google Scholar

Bonaccorso S, , Metastasio A, , Ricciardi A, et al. Synthetic cannabinoid use in a case series of patients with psychosis presenting to acute psychiatric settings: clinical presentation and management issues. Brain Sci 2018;8(7):133. https://doi.org/10.3390/brainsci8070133Google Scholar

Mitcheson, L, McCambridge, J, Byrne, A, Hunt, N, Winstock, A. Sexual health risk among dance drug users: cross-sectional comparisons with nationally representative data. Int J Drug Policy 2008;19(4):304–310. https://doi.org/10.1016/j.drugpo.2007.02.002CrossRefGoogle ScholarPubMed

Sutherland, R, Peacock, A, Whittaker, E, et al. New psychoactive substance use among regular psychostimulant users in Australia, 2010–2015. Drug Alcohol Depend 2016;161:110–118.Google Scholar

Singh AK. Alcohol, interaction with cocaine, methamphetamine, opioids, nicotine, cannabis, and γ-hydroxybutyric acid. Biomedicines 2019;7:16. https://doi.org/10.3390/biomedicines7010016Google Scholar

Sutherland, R, Peacock, A, Whittaker, E, et al. New psychoactive substance use among regular psychostimulant users in Australia, 2010–2015. Drug Alcohol Depend 2016;161:110–118.CrossRefGoogle ScholarPubMed

European Monitoring Centre for Drugs and Drug Addiction. European Drug Report 2019: Trends and Developments. Publications Office of the European Union, Luxembourg, 2019.Google Scholar

Measham, F, Moore, K. Repertoires of distinction: exploring patterns of weekend poly-drug use within local leisure scenes across the English night-time economy. Criminal Justice 2009;9(4):437–464.Google Scholar

Hoare, R, Flatley, J. Drug Misuse Declared: Findings from the 2007/2008 British Crime Survey (Home Office Statistical Bulletin 13/10). Home Office, 2008.Google Scholar

Vento, AE, Martinotti, G, Cinosi, E, et al. Substance use in the club scene of Rome: a pilot study. Biomed Res Int 2014;2014:617546. https://doi.org/10.1155/2014/617546CrossRefGoogle Scholar

Fernández-Calderóna F, , Cleland CM, , Palamar JJ., Polysubstance use profiles among electronic dance music party attendees in New York City and their relation to use of new psychoactive substances. Addict Behav 2018;78:85–93. https://doi.org/10.1016/j.addbeh.2017.11.004Google Scholar

Fernández-Calderón, F, Lozano, OM, Vidal, C, et al. Polysubstance use patterns in underground rave attenders: a cluster analysis. J Drug Educ 2011;41:183–202. http://dx.doi.org/10.2190/DE.41.2.dGoogle Scholar

Palamar, JJ, Griffin-Tomas, M, Ompad, DC. Illicit drug use among rave attendees in a nationally representative sample of US high school seniors. Drug Alcohol Depend 2015a;152:24–31. http://dx.doi.org/10.1016/j.drugalcdep.2015.05.002Google Scholar

Palamar, JJ, Acosta, P, Ompad, DC, Cleland, CM. Self-reported ecstasy/MDMA/“Molly” use in a sample of nightclub and dance festival attendees in New York City. Subst Use Misuse 2016;52(1):82–91. http://dx.doi.org/10.1080/10826084.2016.1219373Google Scholar

Palamar, JJ, Acosta, P, Sherman, S, Ompad, DC, Cleland, CM. Self-reported use of novel psychoactive substances among attendees of electronic dance music venues. Am J Drug Alcohol Abuse 2016;42:624–632. http://dx.doi.org/10.1080/00952990.2016.1181179Google Scholar

Palamar, JJ, Barratt, MJ, Ferris, JA, Winstock, AR. Correlates of new psychoactive substance use among a self-selected sample of nightclub attendees in the United States. Am J Addict 2016c;25:400–407. http://dx.doi.org/10.1111/ajad.12403Google Scholar

Measham, F, Moore, K. Repertoires of distinction: exploring patterns of weekend poly-drug use within local leisure scenes across the English night-time economy. Criminal Justice 2009;9(4):437–464.Google Scholar

Home Office and Office for National Statistics. Drug Misuse: Findings from the 2017/2018 Crime Survey for England and Wales Statistical Bulletin 14/18 July 2018.Google Scholar

Schuler, MS, Stein BD, Collins RL. Differences in substance use disparities across age groups in a national cross-sectional survey of lesbian, gay, and bisexual adults. LGBT Health 2019;6(1):68–76.Google Scholar

Newcomb, ME, Birkett, M, Corliss, HL, Mustanski B. Sexual orientation, gender, and racial differences in illicit drug use in a sample of US high school students. Am J Public Health 2014;104:304–310.Google Scholar

Corliss, HL, Rosario, M, Wypij, D, et al. Sexual orientation and drug use in a longitudinal cohort study of US adolescents. Addict Behav 2010;35:517–521.Google Scholar

Mereish, EH, Goldbach, JT, Burgess, C, DiBello AM. Sexual orientation, minority stress, social norms, and substance use among racially diverse adolescents. Drug Alcohol Depend 2017;178:49–56.Google Scholar

Seil, KS, Desai, MM, Smith MV. Sexual orientation, adult connectedness, substance use, and mental health outcomes among adolescents: findings from the 2009 New York City Youth Risk Behavior Survey. Am J Public Health 2014;104:1950–1956.Google Scholar

Goldbach, JT, Tanner-Smith, EE, Bagwell, M, Dunlap S. Minority stress and substance use in sexual minority adolescents: a meta-analysis. Prev Sci 2014;15:350–363.Google Scholar

Marshal, MP, Dermody, SS, Shultz, ML, et al. Mental health and substance use disparities among urban adolescent lesbian and bisexual girls. J Am Psychiatr Nurses Assoc 2013;19:271–279.Google Scholar

Halkitis, PN, Palamar, JJ. GHB use among gay and bisexual men. Addict Behav 2006;31(11):2135–2139.Google Scholar

Bourne A, Reid D, Hickson F, et al. Illicit drug use in sexual settings (‘chemsex’) and HIV/STI transmission risk behaviour among gay men in South London: findings from a qualitative study. Sex Transm Infect 2015;91:564–568.Google Scholar

Abdulrahim, D, Whiteley, C, Moncrieff, M, Club Drug, Bowden-Jones O Use among Lesbian, Gay, Bisexual and Trans (LGBT) People. Novel Psychoactive Treatment UK Network (NEPTUNE). London, 2016.Google Scholar

Kirby, T, Thornber-Dunwell, M. High-risk drug practices tighten grip on London gay scene. Lancet 2013;381(9861):101–102.Google Scholar

Ahmed, AK, Weatherburn P, Reid D, et al. Social norms related to combining drugs and sex (‘chemsex’) among gay men in South London. Int J Drug Policy 2016;38:29–35.Google Scholar

Evers, YJ, Hoebe, CJPA, Dukers-Muijrers, NHTM, et al. Sexual, addiction and mental health care needs among men who have sex with men practicing chemsex: a cross-sectional study in the Netherlands. Prev Med Rep 2020;18:101074.Google Scholar

Frankis, J, Flowers, P, McDaid, L, Bourne, A. Low levels of chemsex amongst men who have sex with men, but high levels of risk among men who engage in chemsex: analysis of a cross-sectional online survey across four countries. Sex Health 2018;15(2): 144–150. https://doi.org/10.1071/SH17159Google Scholar

Giorgetti, R, Tagliabracci A, , Schifano F, et al. When ‘chems’ meet sex: a rising phenomenon called ‘chemsex’. Curr Neuropharmacol 2017;15(5):762–770.Google Scholar

Graf N, Dichtl A, Deimel D, Sander D, Stöver H. Chemsex among men who have sex with men in Germany: motives, consequences and the response of the support system. Sex Health 2018;15(2):151–156. https://doi.org/10.1071/SH17142Google Scholar

Hammoud MA, Bourne A, Maher L, et al. Intensive sex partying with gamma-hydroxybutyrate: factors associated with using gamma-hydroxybutyrate for chemsex among Australian gay and bisexual men – results from the Flux Study. Sex Health 2018;15(2):123–134. https://doi.org/10.1071/SH17146Google Scholar

Hegazi A., Lee MJ, Whittaker W, et al. Chemsex and the city: sexualised substance use in gay bisexual and other men who have sex with men attending sexual health clinics. Int J STD AIDS 2017;28(4):423.CrossRefGoogle Scholar

Hibbert MP, Brett CE, Porcellato LA, Hope VD. Psychosocial and sexual characteristics associated with sexualised drug use and chemsex among men who have sex with men (MSM) in the UK. Sex Transm Infect (online). Available at: https://sti.bmj.com/content/sextrans/early/2019/04/12/sextrans-2018-053933.full.pdf [last accessed 15 February 2022].Google Scholar

Hockenhull J, Murphy KG, Paterson S. An observed rise in g-hydroxybutyrate-associated deaths in London: evidence to suggest a possible link with concomitant rise in chemsex. Forensic Sci Int 2017;270:93–97.Google Scholar

O’Reilly, M. Chemsex case study: is it time to recommend routine screening of sexualised drug use in men who have sex with men? Sex Health 2018;15(2):167–169. https://doi.org/10.1071/SH17156Google Scholar

Pollard, A, Nadarzynski, T, Llewellyn, C. Syndemics of stigma, minority-stress, maladaptive coping, risk environments and littoral spaces among men who have sex with men using chemsex. Cult Health Sex 2018;20:411–427.Google Scholar

Pufall, EL, Kall M, Shahmanesh M, et al. Sexualized drug use (‘chemsex’) and high-risk sexual behaviours in HIV positive men who have sex with men. HIV Med 2018;19(4):261–270.Google Scholar

Stevens, O, Forrest, JI. Thinking upstream: the roles of international health and drug policies in public health responses to chemsex. Sex Health 2018;15(2):108–115. https://doi.org/10.1071/SH17153Google Scholar

Ruane D., Field experiments: psychonauts’ efforts to reduce the harm of old and new drugs at music festivals. Drugs Educ Prevent Policy 2018;25(4):337–344. https://doi.org/10.1080/09687637.2017.1418836Google Scholar

European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). EMCDDA–Europol 2012 Annual Report on the Implementation of Council Decision 2005/387/JHA. Publications Office of the European Union, Luxemburg, 2012.Google Scholar

Schifano, F, Deluca, P, Baldacchino, A, et al. Drugs on the web; the Psychonaut 2002 EU project. Prog Neuropsychopharmacol Biol Psychiatry 2006;30(4):640–646.Google Scholar

Schifano F. Analyzing the open/deep web to better understand the new/novel psychoactive substances (NPS) scenarios: suggestions from CASSANDRA and NPS Finder Research Projects. Brain Sci 2020;10:146. https://doi.org/10.3390/brainsci10030146Google Scholar

European Monitoring Centre for Drugs and Drug Addiction. European Drug Report 2017: Trends and Developments. Publications Office of the European Union, Luxembourg, 2017.Google Scholar

Corazza, O, Schifano, F, Farre, M, et al. Designer drugs on the internet: a phenomenon out-of-control? The emergence of hallucinogenic drug Bromo-Dragonfly. Curr Clin Pharmacol 2011;6(2):125–129.CrossRefGoogle ScholarPubMed

Corazza, O, Schifano, F, Simonato, P, et al. Phenomenon of new drugs on the internet: the case of ketamine derivative methoxetamine. Hum Psychopharmacol Clin Exp 2012;27(2):145–149.Google Scholar

Corazza, O, Valeriani, G, Bersani, FS, et al. “Spice, , ” “Kryptonite,” “Black Mamba”: an overview of brand names and marketing strategies of novel psychoactive substances on the web. J Psychoactive Drugs 2014;46(4):287–294.Google Scholar

Orsolini L, Papanti D, Corkery J, Schifano F. An insight into the deep web; why it matters for addiction psychiatry? Hum Psychopharmacol Clin Exp 2017;32:e2573. https://doi.org/10.1002/hup.2573Google Scholar

European Monitoring Centre for Drugs and Drug Addiction and Europol. Drugs and the Darknet: Perspectives for Enforcement, Research and Policy. EMCDDA–Europol Joint publications. Publications Office of the European Union, Luxembourg, 2017.Google Scholar

Orsolini L, Papanti D, Corkery J, Schifano F. An insight into the deep web; why it matters for addiction psychiatry? Hum Psychopharmacol Clin Exp 2017;32:e2573. https://doi.org/10.1002/hup.2573Google Scholar

van der Gouwe D, Brunt TM, van Laar M, van der Pol P. Purity, adulteration and price of drugs bought on-line versus off-line in the Netherlands (online). https://doi.org/10.1111/add.13720Google Scholar

In Focus: Trafficking over the Darknet – World Drug Report 2020. www.unodc.org/documents/Focus/WDR20_Booklet_4_Darknet_web.pdf [last accessed 9 February 2022].Google Scholar

European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). EMCDDA–Europol 2012 Annual Report on the Implementation of Council Decision 2005/387/JHA. Publications Office of the European Union, Luxembourg, 2012.Google Scholar

Hout, Van MC. Nod and wave: an Internet study of the codeine intoxication phenomenon. Int J Drug Policy 2015;26:67–77.Google Scholar

European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). Recent Changes in Europe’s Cocaine Market. Results from an EMCDDA Trendspotter Study. Publications Office of the European Union, Luxembourg, 2018.Google Scholar

Schifano, F. Novel psychoactive substances (NPS): clinical and pharmacological issues. Drugs Alcohol Today 2015;15(1):21–27.Google Scholar

Schifano, F, Orsolini, L, Duccio Papanti, G, Corkery, JM. Novel psychoactive substances of interest for psychiatry. World Psychiatry 2015;14(1):15–26.Google Scholar

van Amsterdam, J, Nutt, D, Phillips, L, van den Brink, W. European rating of drug harms. J Psychopharmacology 2015;29(6):655–660. https://doi.org/10.1177/0269881115581980Google Scholar

Gable, RS. Acute toxic effects of club drugs. J Psychoactive Drugs 2004;36(3):303–313.Google Scholar

Gable, RS. Comparison of acute lethal toxicity of commonly abused psychoactive substances. Addiction 2004;99(6):686–696.Google Scholar

Luethia D, , Kolaczynskaa KE, , Doccia L, , Krähenbühla S, , Hoenerb MC, , Liechti ME., Pharmacological profile of mephedrone analogs and related new psychoactive substances. Neuropharmacology 2018;134(Part A):4–12.Google Scholar

Centre for Public Health, Faculty of Health and Applied Social Science, Liverpool John Moore’s University, on behalf of the Department of Health and National Treatment Agency for Substance Misuse. A Summary of the Health Harms of Drugs. Department of Health, 2011.Google Scholar

Elliott S, , Sedefov R, , Evans‐Brown M. Assessing the toxicological significance of new psychoactive substances in fatalities. Drug Test Anal 2018;10:120–126.Google Scholar

European Monitoring Centre for Drugs and Drug Addiction. European Drug Report: Trends and Developments. Published 2016. Available at: https://dx.doi.org/10.2810/Google Scholar

Evans‐Brown, M, Sedefov, R. New psychoactive substances: driving greater complexity into the drug problem. Addiction 2017;112:36.CrossRefGoogle ScholarPubMed

Gable, RS. Acute toxic effects of club drugs. J Psychoactive Drugs 2004;36(3):303–313.Google Scholar

King LA, , Corkery JM., An index of fatal toxicity for new psychoactive substances. J Psychopharmacol 2018; 32(7):793–801.Google Scholar

National Records of Scotland Drug-related Deaths in Scotland in 2019. Published on 15 December 2020.Google Scholar

Nutt, D, King, LA, Saulsbury, W, Blakemore, C. Development of a rational scale to assess the harm of drugs of potential misuse. Lancet 2007;369(9566):1047–1053.Google Scholar

Gable, RS. Comparison of acute lethal toxicity of commonly abused psychoactive substances. Addiction 2004;99(6):686–696.Google Scholar

Centre for Public Health, Faculty of Health and Applied Social Science, Liverpool John Moore’s University, on behalf of the Department of Health and National Treatment Agency for Substance Misuse. A Summary of the Health Harms of Drugs. Department of Health, 2011.Google Scholar

Corazza, O, Schifano, F, Farre, M, et al. Designer drugs on the Internet: a phenomenon out-of-control? The emergence of hallucinogenic drug Bromo-Dragonfly. Curr Clin Pharmacol 2011;6(2):125–129.Google Scholar

Costa, G, De Luca, MA, Piras, G, Marongiu, J, Fattore, L, Simola, N. Neuronal and peripheral damages induced by synthetic psychoactive substances: an update of recent findings from human and animal studies. Neural Regen Res 2020;15(5):802–816. https://doi.org/10.4103/1673-5374.268895Google Scholar

United Nations Office on Drugs and Crime (UNODC). Current NPS Threats, Volume I. Published March 2019. Available at: www.unodc.org/pdf/opioids-crisis/Current_NPS_Threats_-_Volume_I.pdf [last accessed 9 February 2022].Google Scholar

United Nations Office on Drugs and Crime (UNODC). Current NPS Threats, Volume I. Published March 2019. www.unodc.org/pdf/opioids-crisis/Current_NPS_Threats_-_Volume_I.pdf [last accessed 9 February 2022].Google Scholar

Guirguis A, , Girotto S, , Berti B, , Stair JL, . Identification of new psychoactive substances (NPS) using handheld Raman Spectroscopy employing both 785 and 1064 nm laser sources. Forensic Sci Int, published online 4 February 2017. https://doi.org/10.1016/j.forsciint.2017.01.027Google Scholar

Addison M, , Stockdale K, , McGovern R, et al. Exploring the intersections between novel psychoactive substances (NPS) and other substance use in a police custody suite setting in the north east of England. Drugs Educ Prevent Policy 2018;25(4):313–319. https://doi.org/10.1080/09687637.2017.1378620Google Scholar

Brandt, SD, Sumnall, HR, Measham, F, Cole, J. Analyses of second-generation ‘legal highs’ in the UK: initial findings. Drug Test Anal 2010;2(8):377–382. https://doi.org/10.1002/dta.155Google Scholar

Brandt, SD, Sumnall, HR, Measham, F, Cole, J. Second generation mephedrone. The confusing case of NRG-1. BMJ 2010;341:c3564. https://doi.org/10.1136/bmj.c3564Google Scholar

Davies, S, Wood, DM, Smith, G, et al. Purchasing ‘legal highs’ on the Internet: is there consistency in what you get? QJM 2010;103(7):489–493. https://doi.org/10.1093/q jmed/hcq056.Google Scholar

Ramsey, J, Dargan, PI, Smyllie, M, et al. Buying ‘legal’ recreational drugs does not mean that you are not breaking the law. QJM 2010;103(10):777–783. https://doi.org/10.1093/qjmed/hcq132Google Scholar

Ayres, TC, Bond, JW. A chemical analysis examining the pharmacology of novel psychoactive substances freely available over the Internet and their impact on public (ill)health. Legal highs or illegal highs? BMJ Open 2012;2(4):e000977. https://doi.org/10.1136/bmjopen-2012-000977. 2012Google Scholar

Baron, M, Elie, M, Elie, L. An analysis of legal highs: do they contain what it says on the tin? Drug Test Anal 2011;3(9):576–581. https://doi.org/10.1002/dta.274Google Scholar

World Drug Report 2016.Google Scholar

Home Office Annual Report on the Home Office Forensic Early Warning System (FEWS) 2016/17. A system to identify New Psychoactive Substances (NPS) in the UK November 2018. Available from: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/757040/FEWS_Annual_Report_2016-17_STH.pdfGoogle Scholar

See for example: Baron, M, Elie, M, Elie, L. An analysis of legal highs: do they contain what it says on the tin? Drug Test Anal 2011;3(9):576–581. https://doi.org/10.1002/dta.274Google Scholar

James, DA, Potts, S, Thomas, SHL, et al. Clinical features associated with recreational use of ‘Ivory Wave’ preparations containing desoxypipradrol. Clin Toxicol 2011;49:201.Google Scholar

Kalasinsky, KS, Hugel, J, Kish, SJ. Use of MDA (the ‘love drug’) and methamphetamine in Toronto by unsuspecting users of ecstasy (MDMA). J Forensic Sci 2004;49(5):1106–1112.Google Scholar

Parrott, AC. Is ecstasy MDMA? A review of the proportion of ecstasy tablets containing MDMA, their dosage levels, and the changing perceptions of purity. Psychopharmacology 2004;173:234–241.Google Scholar

Cole, JC, Bailey, M, Sumnall, HR, Wagstaff, GF, King, LA. The content of ecstasy tablets: implications for the study of their long-term effects. Addiction 2002;97:1531–1536.Google Scholar

Tanner-Smith, EE. Pharmacological content of tablets sold as ‘ecstasy’: results from an online testing service. Drug Alcohol Depend 2006;83(3):247–254.Google Scholar

Baron, M, Elie, M, Elie, L. An analysis of legal highs: do they contain what it says on the tin? Drug Test Anal 2011;3(9):576–581. https://doi.org/10.1002/dta.274Google Scholar

Brunt, TM, Atkinson, AM, Nefau, T, et al. Online test purchased new psychoactive substances in five different European countries: a snapshot study of chemical composition and price. Int J Drug Policy 2017;44:105–114. https://doi.org/10.1016/j.drugpo.2017.03.006Google Scholar

Brunt, TM, Atkinson, AM, Nefau, T, et al. Online test purchased new psychoactive substances in five different European countries: a snapshot study of chemical composition and price. Int J Drug Policy 2017;44:105–114.Google Scholar

Brunt, TM, Atkinson, AM, Nefau, T, et al. Online test purchased new psychoactive substances in five different European countries: a snapshot study of chemical composition and price. Int J Drug Policy 2017;44:105–114.Google Scholar

Kalasinsky, KS, Hugel, J, Kish, SJ. Use of MDA (the ‘love drug’) and methamphetamine in Toronto by unsuspecting users of ecstasy (MDMA). J Forensic Sci 2004;49(5):1106–1112.Google Scholar

Parrott, AC. Is ecstasy MDMA? A review of the proportion of ecstasy tablets containing MDMA, their dosage levels, and the changing perceptions of purity. Psychopharmacology 2004;173:234–241.Google Scholar

Cole, JC, Bailey, M, Sumnall, HR, Wagstaff, GF, King, LA. The content of ecstasy tablets: implications for the study of their long-term effects. Addiction 2002;97:1531–1536.Google Scholar

Tanner-Smith, EE. Pharmacological content of tablets sold as ‘ecstasy’: results from an online testing service. Drug Alcohol Depend 2006;83(3):247–254.CrossRefGoogle ScholarPubMed

Ciccarone, D, Ondocsin, J, Mars, SG. Heroin uncertainties: exploring users’ perceptions of fentanyl-adulterated and -substituted ‘heroin’. Int J Drug Policy 2017;46:146–155.Google Scholar

Unick, GJ, Ciccarone, D. US regional and demographic differences in prescription opioid and heroin-related overdose hospitalizations. Int J Drug Policy 2017;46:112–119. https://doi.org/10.1016/j.drugpo.2017.06.003Google Scholar

Tomassoni, AJ. Multiple fentanyl overdoses—New Haven, Connecticut, June 23, 2016. Morb Mort Wkly Rep 2017;66:107–111.Google Scholar

Fairbairn, N, Coffin, PO, Walley, AY. Naloxone for heroin, prescription opioid, and illicitly made fentanyl overdoses: challenges and innovations responding to a dynamic epidemic. Int J Drug Policy 2017;46:172–179. https://doi.org/10.1016/j.drugpo.2017.06.005Google Scholar

Krause, D, Plörer, D, Koller, G, et al. High concomitant misuse of fentanyl in subjects on opioid maintenance treatment. Subst Use Misuse 2017;52(5):639–645.Google Scholar

Cicero, TJ, Ellis, MS, Kasper, ZA. Increases in self-reported fentanyl use among a population entering drug treatment: the need for systematic surveillance of illicitly manufactured opioids. Drug Alcohol Depend 2017;177:101–103. https://doi.org/10.1016/j.drugalcdep.2017.04.004Google Scholar

Ciccarone, D, Ondocsin, J, Mars, SG. . Heroin uncertainties: exploring users’ perceptions of fentanyl-adulterated and -substituted ‘heroin’. Int J Drug Policy 2017;46:146–155.Google Scholar

Caudevilla-Gálligo, F, Riba, J, Ventura, M, et al. 4-bromo-2,5-dimethoxyphenethylamine (2C-B): presence in the recreational drug market in Spain, pattern of use and subjective effects. J Psychopharmacol 2012;26(7):1026–1035. https://doi.org/10.1177/0269881111431752Google Scholar

Liakoni E, Yates C, Dines, AM, et al. Acute recreational drug toxicity. Medicine 2018;97(5):e9784. https://doi.org/10.1097/MD.0000000000009784Google Scholar

European Monitoring Centre for Drugs and Drug Addiction. European Drug Report 2019: Trends and Developments. Publications Office of the European Union, Luxembourg, 2019.Google Scholar

Wood DM, , De La Rue L, , Hosin AA, et al. Dargan poor identification of emergency department acute recreational drug toxicity presentations using routine hospital coding systems: the experience in Denmark, Switzerland and the UK. J Med Toxicol 2019;15:112–120. https://doi.org/10.1007/s13181-018-0687-zGoogle Scholar

Wood, DM, Conran, P, Dargan, PI. ICD- 10 coding: poor identification of recreational drug presentations to a large emergency department. Emerg Med 2011;28:387–389.Google Scholar

Shah, AD, Wood, DM, Dargan, PI. Survey of ICD-10 coding of hospital admissions in the UK due to recreational drug toxicity. QJM 2011;104:779–784.Google Scholar

Wood DM, , De La Rue L, , Hosin AA, et al. Dargan poor identification of emergency department acute recreational drug toxicity presentations using routine hospital coding systems: the experience in Denmark, Switzerland and the UK. J Med Toxicol 2019;15:112–120. https://doi.org/10.1007/s13181-018-0687-zGoogle Scholar

Poznyak V, Reed GM, Medina-Mora ME. Aligning the ICD-11 classification of disorders due to substance use with global service needs. Epidemiol Psychiatr Sci (online). https://doi.org/10.1017/S2045796017000622Google Scholar

International Classification of Diseases for Mortality and Morbidity Statistics, 11th edn., v2019-04 6C47. Disorders due to use of synthetic cathinones. Available at: https://icd.who.int/browse11/l-m/en#/http://id.who.int/icd/entity/1605818663 [last accessed 15 February 2022].Google Scholar

International Classification of Diseases for Mortality and Morbidity Statistics, 11th edn., v2019-04 6C42. Disorders due to use of synthetic cannabinoids. Available at: https://icd.who.int/browse11/l-m/en#/http://id.who.int/icd/entity/804833492 [last accessed 15 February 2022].Google Scholar

International Classification of Diseases for Mortality and Morbidity Statistics, 11th ed., v2019-04 6C4C. Disorders due to use of MDMA or related drugs, including MDA. Available at: https://icd.who.int/browse11/l-m/en#/http://id.who.int/icd/entity/1218193465[lastaccessed15February2022].Google Scholar

Wood DM, , De La Rue L, , Hosin AA, et al. Dargan poor identification of emergency department acute recreational drug toxicity presentations using routine hospital coding systems: the experience in Denmark, Switzerland and the UK. J Med 673 Col:311Toxicol 2019;15:112–120. https://doi.org/10.1007/s13181-018-0687-zGoogle Scholar

European Monitoring Centre for Drugs and Drug Addiction. European Drug Report 2019: Trends and Developments. Publications Office of the European Union, Luxembourg, 2019.Google Scholar

Wood, DM, Heyerdahl, F, Yates, CB, et al. The European Drug Emergencies Network (Euro-DEN). Clin Toxicol 2014;52(4):239–241. https://doi.org/10.3109/15563650.2014.898771Google Scholar

European Monitoring Centre for Drugs and Drug Addiction. Drug-related hospital emergency presentations in Europe: update from the Euro-DEN Plus expert network, technical report. Publications Office of the European Union, Luxembourg, 2020.Google Scholar

European Monitoring Centre for Drugs and Drug Addiction. European Drug Report 2019: Trends and Developments. Publications Office of the European Union, Luxembourg, 2019.Google Scholar

European Monitoring Centre for Drugs and Drug Addiction. European Drug Report 2019: Trends and Developments. Publications Office of the European Union, Luxembourg, 2019.Google Scholar

Hunter, LJ, Dargan, PI, Benzie, A, White, JA, Wood, DM. Recreational drug use in men who have sex with men (MSM) attending UK sexual health services is significantly higher than in non-MSM. Postgrad Med J 2014;90(1061):133–138. https://doi.org/10.1136/postgradmedj-2012-131428Google Scholar

Scottish Government. The Sexual Health and Blood Borne Virus Framework 2011–2015.Google Scholar

Department of Health. A Framework for Sexual Health Improvement in England. Published 2013.Google Scholar

Royal College of Physicians. Alcohol and Sex: A Cocktail for Poor Sexual Health (Report of the Alcohol and Sexual Health Working Party). Published 2011.Google Scholar

British HIV Association. Standards of Care for People Living with HIV in 2013. Available at: www.bhiva.org/file/WSheCFExXGBRK/BHIVAStandardsA4.pdf [last accessed 15 February 2022].Google Scholar

Hunter, LJ, Dargan, PI, Benzie, A, White, JA, Wood, DM. Recreational drug use in men who have sex with men (MSM) attending UK sexual health services is significantly higher than in non-MSM. Postgrad Med J 2014;90(1061):133–138. https://doi.org/10.1136/postgradmedj-2012-131428Google Scholar

Bowden-Jones O. Joining up sexual health and drug services to better meet client needs. Background paper commissioned by the EMCDDA for Health and social responses to drug problems: a European guide. Available at: www.emcdda.europa.eu/system/files/attachments/6239/EuropeanResponsesGuide2017_BackgroundPaper-Sexual-health-and-drug-use.pdf [last accessed 15 February 2022].Google Scholar

National Institute for Health and Care Excellence. Alcohol-Use Disorders: Preventing Harmful Drinking (PH24). Published 2010.Google Scholar

British Association of Sexual Health and HIV. Standards for the management of sexually transmitted infections (STIs). Published 2019. Available at: www.bashh.org/about-bashh/publications/standards-for-the-management-of-stis/ [last accessed 15 February 2022].Google Scholar

British Association of Sexual Health and HIV. Standards for the management of sexually transmitted infections (STIs). Published 2019. Available at: www.bashh.org/about-bashh/publications/standards-for-the-management-of-stis/ [last accessed 15 February 2022].Google Scholar

Department of Health and Social Care, Public Health England. Integrated Sexual Health Services. A suggested national service specification. Published August 2018. Available at: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/731140/integrated-sexual-health-services-specification.pdf [last accessed 15 February 2022].Google Scholar

World Health Organization. International Standards for the Treatment of Drug Use Disorders. Revised edition incorporating results of field-testing. 31 March 2020. Available from: www.who.int/publications/i/item/international-standards-for-the-treatment-of-drug-use-disordersGoogle Scholar

United Nations Office for Drugs and Crime, World Health Organization. Principles of Drug Dependence Treatment. Published March 2008. Available at: www.unodc.org/documents/drug-treatment/UNODC-WHO-Principles-of-Drug-Dependence-Treatment-March08.pdf [last accessed 15 February 2022].Google Scholar

Panagopoulos, I, Ricciardelli, LA. Harm reduction and decision making among recreational ecstasy users. Int J Drug Policy 2005;16:54–64.Google Scholar

Fernández-Calderón, F, Lozano-Rojas, Ó, Rojas-Tejada, A, et al. Harm reduction behaviors among young polysubstance users at raves. Subst Abuse 2014;35:45–50.Google Scholar

Greenspan, NR, Aguinaldo, JP, Husbands, W, et al. “It’s not rocket science, what I do”: self-directed harm reduction strategies among drug using ethno-racially diverse gay and bisexual men. Int J Drug Policy 2011;22:56–62.Google Scholar

Cruz, OS. Non problematic illegal drug use: drug use management strategies in a Portuguese sample. J Drug Issues 2015;45:133–150.Google Scholar

Fernández-Calderón F, , Díaz-Batanero C, , Barratt MJ, , Palamar JJ. Harm reduction strategies related to dosing and their relation to harms among festival attendees who use multiple drugs. Drug Alcohol Rev 2019;38:57–67. https://doi.org/10.1111/dar.12868Google Scholar

Strang, J, Chair of the Expert Group. Recovery-Orientated Drug Treatment. An Interim Report. National Treatment Agency for Substance Misuse, 2011.Google Scholar

Amato, L, Minozzi, S, Davoli, M, Vecchi, S. Psychosocial and pharmacological treatments versus pharmacological treatments for opioid detoxification. Cochrane Database Syst Rev 2011;7(9):CD005031. https://doi.org/10.1002/14651858.CD005031.pub4Google Scholar

National Institute for Health and Clinical Excellence. Drug Misuse: Psychosocial Interventions (Clinical Guideline 51). Published 2007.Google Scholar

National Institute for Health and Clinical Excellence. Quality Standard for Drug Use Disorders (Quality Standard 23). Published 2012.Google Scholar

Department of Health (England) and the Devolved Administrations. Drug Misuse and Dependence: UK Guidelines on Clinical Management. Department of Health, the Scottish Government, the Welsh Assembly Government and Northern Ireland Executive, 2007.Google Scholar

National Institute for Health and Clinical Excellence. Behaviour Change: Individual Approaches (PH 49). Published 2014.Google Scholar

National Institute for Health and Clinical Excellence. Alcohol Use Disorders: Harmful Drinking and Alcohol Dependence (Clinical Guidance 115: Evidence Update). Published 2013.Google Scholar

Smedslund, G, Berg, RC, Hammerstrøm, KT, et al. Motivational interviewing for substance abuse. Cochrane Database Syst Rev 2011;11(5):CD008063. https://doi.org/10.1002/14651858.CD008063.pub2Google Scholar

Knapp, WP, Soares, BG, Farrel, M, Lima, MS. Psychosocial interventions for cocaine and psychostimulant amphetamines related disorders. Cochrane Database Syst Rev 2007;18(3):CD003023.Google Scholar

National Treatment Agency for Substance Misuse. The Effectiveness of Psychological Therapies on Drug Misusing Clients. Published 2005.Google Scholar

Orford, J. Asking the right questions in the right way: the need for a shift in research on psychological treatments for addiction. Addiction 2008;103(6):875–885; discussion 886–892. https://doi.org/10.1111/j.1360-0443.2007.02092.xGoogle Scholar

European Monitoring Centre for Drugs and Drug Addiction. Health and Social Responses to Drug Problems: A European Guide. Publications Office of the European Union, Luxembourg, 2017.Google Scholar

The United Nations Office on Drugs and Crime (UNODC). World Drug Report 2019 (United Nations publication, Sales No. E.19.XI.8). Available at: https://wdr.unodc.org/wdr2019/prelaunch/WDR19_Booklet_1_EXECUTIVE_SUMMARY.pdfGoogle Scholar

European Monitoring Centre for Drugs and Drug Addiction. Health and Social Responses to Drug Problems: A European Guide. Publications Office of the European Union, Luxembourg, 2017.Google Scholar

Tompkins CN, Neale J. Delivering trauma-informed treatment in a women-only residential rehabilitation service: qualitative study. Drugs Educ Prevent Policy 2018;25(1):47–55.Google Scholar

Carlyle M, Broomby R, Simpson G, et al. A randomised, double-blind study investigating the relationship between early childhood trauma and the rewarding effects of morphine. Addict Biol 2021:e13047 (online). https://doi.org/10.1111/adb.13047.Google Scholar

Dube, SR, Felitti, VJ, Dong, M, Chapman, DP, Giles, WH, Anda, RF. Childhood abuse, neglect, and household dysfunction and the risk of illicit drug use: the adverse childhood experiences study. Pediatrics 2003;111(3):564–572.Google Scholar

Kristjansson, S, McCutcheon, VV, Agrawal, A, et al. The variance shared across forms of childhood trauma is strongly associated with liability for psychiatric and substance use disorders. Brain Behav 2016;6(2):e00432.Google Scholar

Naqavi, MR, Mohammadi, M, Salari, V, Nakhaee, N. The relationship between childhood maltreatment and opiate dependency in adolescence and middle age. Addict Health 2011;3(3–4):92–98.Google Scholar

Taplin, C, Saddichha, S, Li, K, Krausz, MR. Family history of alcohol and drug abuse, childhood trauma, and age of first drug injection. Subst Use Misuse 2014;49(10):1311–1316.Google Scholar

Vogel, M, Dursteler-Macfarland, KM, Walter, M, et al. Prolonged use of benzodiazepines is associated with childhood trauma in opioid-maintained patients. Drug Alcohol Depend 2011;119(1–2):93–98.Google Scholar

Kumar, N, Stowe, ZN, Han, X, Mancino, MJ. Impact of early childhood trauma on retention and phase advancement in an outpatient buprenorphine treatment program. Am J Addict 2016;25(7):542–548.Google Scholar

Mandavia, A, Robinson, GG, Bradley, B, Ressler, KJ, Powers, A. Exposure to childhood abuse and later substance use: indirect effects of emotion dysregulation and exposure to trauma. J Trauma Stress 2016;29(5):422–429.Google Scholar

European Monitoring Centre for Drugs and Drug Addiction. Prison and Drugs in Europe: Current and Future Challenges. Publications Office of the European Union, Luxembourg, 2021.Google Scholar

Fuentes, CM. Nobody’s child: the role of trauma and interpersonal violence in women’s pathways to incarceration and resultant service needs. Med Anthropol Q 2014;28(1):85–104.Google Scholar

Jones, MS, Worthen, MGF, Sharp, SF, McLeod, DA. Life as she knows it: the effects of adverse childhood experiences on intimate partner violence among women prisoners. Child Abuse Negl 2018;85:68–79.Google Scholar

Fallot, RD, Harris, M. Trauma-Informed Services: A Self-Assessment and Planning Protocol. Washington, DC: Community Corrections, 2002.Google Scholar

Bateman, J, Henderson, C, Kezelman, C. Trauma-Informed Care and Practice: Towards a Cultural Shift in Policy Reform across Mental Health and Human Services in Australia. Mental Health Coordinating Council, 2013.Google Scholar

Brown, VB, Harris, M, Fallot, R. Moving toward trauma-informed practice in addiction treatment: a collaborative model of agency assessment. J Psychoactive Drugs 2013;45(5):386–393.Google Scholar

Harris, M, Fallot, R. Using Trauma Theory to Design Service Systems. San Francisco: Jossey-Bass, 2001.Google Scholar

Harris, M. Trauma Recovery and Empowerment: A Clinician’s Guide for Working with Women in Groups. New York: The Free Press, 1998.Google Scholar

Fallot, R, Harris, M. Creating Cultures of Trauma-Informed Care (CCTIC): A Self-Assessment and Planning Protocol. Washington, DC: Community Corrections, 2009.Google Scholar

Tompkins, CNE, Neale, J. Delivering trauma-informed treatment in a women-only residential rehabilitation service: qualitative study. Drugs Educ Prevent Policy 2018;25(1):47–55. https://doi.org/10.1080/09687637.2016.1235135Google Scholar

Hales, TW, Green, SA, Bissonette, S, et al. Trauma-informed care outcome study. Res Soc Work Pract 2019;29(5):529–539. https://doi.org/10.1177/1049731518766618Google Scholar

Mitcheson, L, Maslin, J, Meynen, T, Morrison, T, Hill, R, Wanigaratne, S. Applied Cognitive and Behavioural Approaches to the Treatment of Addiction: A Practical Treatment Guide. Wiley-Blackwell, 2010.Google Scholar

Pilling, S, Hesketh, K, Mitcheson, L. Routes to Recovery: Psychosocial Interventions for Drug Misuse. A Framework and Toolkit for Implementing NICE-Recommended Treatment Interventions. National Treatment Agency for Substance Misuse and British Psychological Society, 2010.Google Scholar

Marsden, J, Eastwood, B, Ali, R, et al. Development of the Addiction Dimensions for Assessment and Personalised Treatment (ADAPT). Drug Alcohol Depend 2014;139:121–131. https://doi.org/10.1016/j.drugalcdep.2014.03.018Google Scholar

HM Government. The Drug Strategy: ‘Reducing Demand, Restricting Supply, Building Recovery: Supporting People to Live a Drug Free Life’. Published 2010.Google Scholar

Orford, J. Power, Powerlessness and Addiction. Cambridge: Cambridge University Press, 2013.Google Scholar

Winstock, AR, Mitcheson, L. New recreational drugs and the primary care approach to patients who use them. BMJ 2012;344:e288. https://doi.org/10.1136/bmj.e288Google Scholar

Hunter, LJ, Dargan, PI, Benzie, A, White, JA, Wood, DM. Recreational drug use in men who have sex with men (MSM) attending UK sexual health services is significantly higher than in non-MSM. Postgrad Med J 2014;90(1061):133–138. https://doi.org/10.1136/postgradmedj-2012-131428Google Scholar

Colfax, G, Guzman, R. Club drugs and HIV infection: a review. Clin Infect Dis 2006;42(10):1463–1469.Google Scholar

Weaver, T, Madden, P, Charles, V, et al. Comorbidity of substance misuse and mental illness in community mental health and substance misuse services. Br J Psychiatry 2003;183:304–313.Google Scholar

Heather, N, Lavoie, D, Morris, J. Clarifying Alcohol Brief Interventions: 2013 Update. Alcohol Academy, 2013.Google Scholar

Miller, WR, Rollnick, S. Motivational Interviewing: Helping People Change (3rd edition). Guilford, 2013.Google Scholar

Miller, WR, Sanchez, VC. Motivating young adults for treatment and lifestyle change. In: Howard, G, ed. Issues in Alcohol Use and Misuse in Young Adults. University of Notre Dame Press, 1993.Google Scholar

National Treatment Agency for Substance Misuse. Care Planning Practice Guide. Published 2006.Google Scholar

Humeniuk, RE, Henry-Edwards, S, Ali, RL, Poznyak, V, Monteiro, M. The ASSIST-Linked Brief Intervention for Hazardous and Harmful Substance Use: Manual for Use in Primary Care. Geneva, World Health Organization, 2010.Google Scholar

Independent Expert Working Group. Drug Misuse and Dependence: UK Guidelines on Clinical Management. London: Department of Health, 2017. Available from: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/673978/clinical_guidelines_2017.pdfGoogle Scholar

National Treatment Agency for Substance Misuse. The International Treatment Effectiveness Project: Implementing Psychosocial Interventions for Adult Drug Misusers. Published 2007.Google Scholar

Day, E. Routes to Recovery via the Community. Public Health England, 2013.Google Scholar

National Institute for Health and Care Excellence. Drug Misuse in Over 16s: Psychosocial Interventions. NICE Clinical Guideline 51. London: NICE, 2007.Google Scholar

Division of Clinical Psychology, British Psychological Society. Good Practice Guidelines on the Use of Psychological Formulation. Published 2011.Google Scholar

Bourne A, Reid D, Hickson F, Torres-Rueda S, Weatherburn P. Illicit drug use in sexual settings (‘chemsex’) and HIV/STI transmission risk behaviour among gay men in South London: findings from a qualitative study. Sex Transm Infect 2015;91(8):564–568.Google Scholar

Lee, NK, Rawson, RA. A systematic review of cognitive and behavioural therapies for methamphetamine dependence. Drug Alcohol Rev 2008;27(3):309–317. https://doi.org/10.1080/09595230801919494Google Scholar

Reback, CJ, Larkins, S, Shoptaw, S. Changes in the meaning of sexual risk behaviors among gay and bisexual male methamphetamine abusers before and after drug treatment. AIDS Behav 2004;8(1):87–9Google Scholar

Rajasingham, R, Mimiaga, MJ, White, JM, Pinkston, MM, Baden, RP, Mitty, JA. A systematic review of behavioral and treatment outcome studies among HIV-infected men who have sex with men who abuse crystal methamphetamine. AIDS Patient Care STDS 2012;26(1):36–52. https://doi.org/10.1089/apc.2011.0153Google Scholar

Melendez-Torres, GJ, Bonell, C. Systematic review of cognitive behavioural interventions for HIV risk reduction in substance-using men who have sex with men. Int J STD AIDS 2013;25(9):627–635Google Scholar

Weiss, RD, Griffin, ML, Gallop, RJ, et al. The effect of 12-step self-help group attendance and participation on drug use outcomes among cocaine-dependent patients. Drug Alcohol Depend 2005;77(2):177–184.Google Scholar

Public Health England. Facilitating Access to Mutual Aid: Three Essential Stages for Helping Clients Access Appropriate Mutual Aid Support. Published 2013. www.nta.nhs.uk/uploads/mutualaid-fama.pdfGoogle Scholar

Pilling S, Hesketh K, Mitcheson L. Routes to Recovery: Psychosocial Interventions for Drug Misuse. A Framework and Toolkit for Implementing NICE-Recommended Treatment Interventions. National Treatment Agency for Substance Misuse and British Psychological Society, 2010.Google Scholar

Fals-Stewart, W, O’Farrell, TJ, Lam, W. Behavioural couples therapy for gay and lesbian couples with alcohol use disorders. J Subst Abuse Treat 2009;37(4):379–387. https://doi.org/10.1016/j.jsat.2009.05.001Google Scholar

Copello, A, Orford, J, Hodgson, R, Tober, G. Social Behaviour Network Therapy for Alcohol Problems. Routledge, 2009.Google Scholar

Miller, WR, Meyers, RT, Hiller-Strumhofel, S. The community reinforcement approach. Alcohol Research Health 1999;23:116–121.Google Scholar

O’Farrell, TJ, Fals-Stewart, W. Behavioural Couples Therapy for Alcoholism and Drug Abuse. Guilford, 2006.Google Scholar

National Institute for Clinical Excellence. Drug Misuse – Psychosocial Interventions. Issued: July 2007. NICE Clinical Guideline 51; guidance.nice.org.uk/cg51.Google Scholar

Marlatt, GA, Donovan, DM, eds. Relapse Prevention: Maintenance Strategies in the Treatment of Addictive Behaviors (2nd ed.). Guilford Press, 2005.Google Scholar

Chiesa, A, Serretti, A. Are mindfulness-based interventions effective for substance use disorders? A systematic review of the evidence. Subst Use Misuse 2014;49(5):492–512. https://doi.org/10.3109/10826084.2013.770027Google Scholar

Zgierska, A, Marcus, MT. Mindfulness-based therapies for substance use disorders: part 2. Subst Abus 2010;31(2):77–78. https://doi.org/10.1080/08897071003641248Google Scholar

Smout, MF, Longo, A, Harrison, S, Minniti, R, Wickes, W, White, JM. Psychosocial treatment for methamphetamine use disorders: a preliminary randomized controlled trial of cognitive behavior therapy and acceptance and commitment therapy. Subst Abus 2010;31(2):98–107. https://doi.org/10.1080/08897071003641578Google Scholar

Kletter, E. Counseling as an intervention for cocaine-abusing methadone maintenance patients. J Psychoactive Drugs 2003;35(2):271–277.Google Scholar