The need for pediatric sedation services has been increasing, as much as 10% per year [1]. In order to meet this need, there will be an increasing number of providers of various backgrounds who will be administering sedation in a non-operating room environment in the future. It is therefore necessary to adhere to standard guidelines for the safe administration of sedation to this special population. Compared to adults, the care of the pediatric patient is often complicated by the need for deeper levels of sedation to achieve therapeutic goals, and the physiologic and anatomic differences that make them more vulnerable to hypoxemia and respiratory arrest that could lead to subsequent cardiac arrest. The requirements for safe sedation have been well summarized by Coté [2]: There is a need for informed consent, a complete medical history, formal evaluation of the airway to anticipate any possible issues, review of fasting status, sufficient physiologic monitoring and staffing by providers who are not involved with the performance of the procedure and who are adequately trained to provided resuscitation if necessary.