The goal of a procedural sedation program is to provide guidance to establish the best standard of care, yielding the best outcome for the patient. This ambition starts with the establishment of an institutional procedural sedation committee. Institutional leadership that provides central oversight for sedation practice is required by The Joint Commission (TJC) and the Centers for Medicare and Medicaid Services (CMS). Due to this requirement many hospitals and organizations have a committee that provides oversight for each area and department providing sedation. The committee structure should include all those providing sedation services to facilitate interprofessional team conversations to ensure optimal sedation practices supported by the anesthesia and nursing professional organizations’ regulatory agency guidelines.