Published online by Cambridge University Press: 14 October 2021
Psychological symptoms commonly occur as a result of both thyroid and parathyroid disorders. Epidemiological studies evaluating the association between thyroid function and mood are heterogeneous in design and report varying results. The larger studies demonstrate no effect or an increase in depression with decreasing thyroid-stimulating hormone concentrations. There is growing evidence supporting the fact that thyroid function in psychiatric patients may be affected by the mental disorder itself, as well as by the medications used to treat that illness. Biochemical assessment of thyroid function and calcium concentrations should form part of the baseline assessment in those who present with new psychological symptoms. Once an abnormality is confirmed, further workup and treatment of the underlying endocrine disorder can be expected to alleviate and even reverse the psychological symptoms.
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