This chapter examines the historical evolution of great powers’ efforts to manage their relations, foster international orders, and promote processes of peaceful change in international relations through the use of international organizations since the Congress of Vienna in 1815. The focus is on the mechanisms and dynamics of balances of power, concert, and collective security, as reflected in the practices of IOs, including diplomatic congresses and conferences of the nineteenth century, the League of Nations, and the United Nations since 1945. The main research question remains: Under which conditions do great powers use international organizations to promote processes of peaceful change in international relations? The relevant conditions include: a stable and agreed systemic distribution of power among the great powers; a certain degree of normative consensus among them; and a minimal agreement upon the “rules of the game” in the management of international relations. Among the findings drawn from the historical record, we can conclude that great powers tend to be status quo-oriented, and that IOs might thrive, prosper, and affect the behavior of great powers when the three basic conditions are in place.