This chapter surveys both the rich tradition of Renaissance botanical literature and some of the critical strategies currently developing around them: ecocriticism, ecofeminism, and critical plant studies. It focuses on the co-existence of myth and science in Renaissance botanical texts and the capacity of Renaissance literature to clarify the advantages and drawbacks of bestowing personhood on plants. Renaissance literature reveals the socio-political, intellectual, and aesthetic processes by which plants became hostage to two separate cultures: the scientific and aesthetic. The chapter also argues that a properly historicised view of Renaissance plant writing might in some respects make early modern texts more relevant to the present by reviving pre-Enlightenment worldviews and pre-Industrial notions of ecological enmeshment.