In this chapter, we provide evidence and examine the changes in health status and health behaviour in the Spanish context during the current pandemic. More specifically, we focus on self-perceived health status and depressive symptomatology, use of medical resources, tobacco consumption, use of drugs, and consumption of certain foods. The findings from this chapter suggest that the first months of the pandemic had an important impact on mental health and health behaviours. The effects of the pandemic were very much gender driven especially for mental health. That is, women exhibit worsened mental health, and for this reason, they end up with a further deterioration of their psychological status. Concerning the change in health behaviour, we see that the pandemic in Spain led to important changes in the use of medical resources, use of drugs, and daily consumption patterns.