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The Impact of Sleep Quality on Cognitive Functioning in Parkinson's Disease

Published online by Cambridge University Press:  09 December 2011

Karina Stavitsky ,
Sandy Neargarder ,
Yelena Bogdanova ,
Patrick McNamara  and
Alice Cronin-Golomb
Karina Stavitsky
Affiliation:
Department of Psychology, Boston University, Boston, Massachusetts
Sandy Neargarder
Affiliation:
Department of Psychology, Boston University, Boston, Massachusetts Department of Psychology, Bridgewater State University, Bridgewater, Massachusetts
Yelena Bogdanova
Affiliation:
Department of Psychology, Boston University, Boston, Massachusetts Psychology Research, VA Boston Healthcare System, Boston, Massachusetts Department of Psychiatry, Harvard Medical School, Boston, Massachusetts
Patrick McNamara
Affiliation:
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts Department of Neurology, VA Boston Healthcare System, Boston, Massachusetts
Alice Cronin-Golomb*
Affiliation:
Department of Psychology, Boston University, Boston, Massachusetts
*
Corresponding author: Alice Cronin-Golomb, Department of Psychology, Boston University, 648 Beacon Street, 2nd Floor, Boston, MA 02215. E-mail: alicecg@bu.edu
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Abstract

In healthy individuals and those with insomnia, poor sleep quality is associated with decrements in performance on tests of cognition, especially executive function. Sleep disturbances and cognitive deficits are both prevalent in Parkinson's disease (PD). Sleep problems occur in over 75% of patients, with sleep fragmentation and decreased sleep efficiency being the most common sleep complaints, but their relation to cognition is unknown. We examined the association between sleep quality and cognition in PD. In 35 non-demented individuals with PD and 18 normal control adults (NC), sleep was measured using 24-hr wrist actigraphy over 7 days. Cognitive domains tested included attention and executive function, memory and psychomotor function. In both groups, poor sleep was associated with worse performance on tests of attention/executive function but not memory or psychomotor function. In the PD group, attention/executive function was predicted by sleep efficiency, whereas memory and psychomotor function were not predicted by sleep quality. Psychomotor and memory function were predicted by motor symptom severity. This study is the first to demonstrate that sleep quality in PD is significantly correlated with cognition and that it differentially impacts attention and executive function, thereby furthering our understanding of the link between sleep and cognition. (JINS, 2012, 18, 108–117)

Keywords

Parkinson's diseaseSleepCognitionExecutive functionActigraphyMemory
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 18 , Issue 1 , January 2012 , pp. 108 - 117
Copyright
Copyright © The International Neuropsychological Society 2011

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