The defence industry plays a critical role in maintaining international peace and security, yet its activities inherently have human rights implications. This article examines the industry’s responsibility to respect human rights in conformity with the United Nations Guiding Principles on Business and Human Rights. It explores challenges, practices, and opportunities of human rights due diligence within the arms sector—including the end-use monitoring component. It seeks to inform policymakers, industry, scholars and activists working towards a rights-respecting arms trade regime. The article will explore human rights due diligence’s foundations in international human rights law and corporate social responsibility frameworks, as well as emerging shifts and standards in the legal landscape at the national, regional, and international levels. Drawing on the American Bar Association Center for Human Rights evidence-based research, this piece will also explore the industry’s response to its due diligence obligations and how these narratives cannot shield the industry from legal, financial and reputational risks.