Let
$R$ be a prime ring of characteristic diòerent from
$2$, let
${{Q}_{r}}$ be its right Martindale quotient ring, and let
$C$ be its extended centroid. Suppose that
$F$ is a generalized skew derivation of
$R,\,L$ a non-central Lie ideal of
$R,\,0\,\ne \,a\,\in \,R,\,m\,\ge \,0$ and
$n,\,s\,\ge \,1$ fixed integers. If
$$a{{\left( {{u}^{m}}F\left( u \right){{u}^{n}} \right)}^{s}}\,=\,0$$
for all
$u\,\in \,L$, then either
$R\,\subseteq \,{{M}_{2}}\left( C \right)$, the ring of
$2\,\times \,2$ matrices over
$C$, or
$m\,=\,0$ and there exists
$b\,\in \,{{Q}_{r}}$ such that
$F\left( x \right)\,=\,bx$, for any
$x\,\in \,R$, with
$ab\,=\,0$.