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2 results

  • 9 - Nanodelivery of Therapeutic Genes

  • James F. Leary, Purdue University, Indiana
  • Book:
    Fundamentals of Nanomedicine
    Published online:
    08 March 2022
    Print publication:
    31 March 2022, pp 159-185

  • Summary

    Typically, there is an optimal dose for treating a diseased cell. But most conventional drug delivery systems have either exponential or biexponential decay characteristics. So-called timed-release drugs create a sawtooth drug delivery pattern, which is a big improvement but still less than optimal. What we really want is to be able to hold the drug delivery to as close to the optimal dose as possible over time. This can best be done using nanomedical systems with biosensing and feedback control systems.

Fundamentals of Nanomedicine
  • James F. Leary
  • Published online:
    08 March 2022
    Print publication:
    31 March 2022
  • The first introductory book on the subject, this book will provide a complete grounding to this pioneering field for students and professionals across biomedical engineering, biology and medicine. It features a comprehensive overview of original work in this revolutionary field. Topics discussed include drug delivery, cell-material interaction and gene therapy, accompanied by real-world examples and over 100 illustrations. The book teaches readers how to design and test their own nanomedical systems for real-world applications in biomedical engineering, medicine and pharmacy. Presenting a thorough discussion of the science and engineering of nanomedicine, it discusses vital environmental, social and ethical impacts of this revolutionary technology. Including over 200 thought-provoking study questions, allowing the reader to self-assess their understanding, this book is a rich source of information that will be of interest and importance in nanomedicine.