This chapter discusses the need for greater coordination and coherence in the design, approval, financing, and implementation of biodiversity, conservation, and nature-based solutions across the MENA region. Considering the wide-ranging impacts of biodiversity loss on water, energy, and food security, as well as on cultural heritage, tourism, urban planning, healthcare, human rights, and other key sectors, comprehensive and wide-ranging responses are required. This chapter therefore examines the guiding principles of implementing a nexus and integrated governance approach across the region to effectively mainstream biodiversity and nature conservation into all aspects of development planning and decision making. It discusses the need for coherent and holistic legal responses; clear and comprehensive legislation; institutional coordination; biodiversity entrepreneurship, increased biodiversity financing; human rights due diligence; and biodiversity-focused environmental law education as essential steps for advancing the nexus and integrated implementation of biodiversity and nature conservation across the MENA region.