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Summary

Hodgkin lymphoma, a nodal disease, is usually diagnosed using morphology and immunochemistry on lymph nodes biopsies. However, with the increased practice of fine-needle aspiration or core biopsy, multiparameter flow cytometry (MFC) can provide valuation information on cell suspensions from such samples. Here, the major markers and characteristics allowing, in MFC, to distinguish between the scarce Reed Sternberg cells and the inflammatory immunological infiltrate surrounding them are described. Guidelines and recent information are provided for readers willing to implement these investigations in their own settings.

Objectives

This study focused on parotid gland tumours diagnosed as benign by fine-needle aspiration cytology and investigated the necessity of frozen section biopsy.

Methods

There were 104 cases of parotid gland tumour where fine-needle aspiration cytology was benign and frozen section biopsy was subsequently performed, between April 2006 and June 2016. In this retrospective study, the results of frozen section biopsy were analysed and compared with the final histological diagnosis.

Results

Among the 104 cases diagnosed as benign by fine-needle aspiration cytology, 102 cases and 2 cases were diagnosed as benign and malignant, respectively, by frozen section biopsy. The final histological diagnoses showed that 98 cases were benign and 6 cases were malignant. The sensitivity and specificity values of frozen section biopsy in detecting malignant tumours were 33 per cent and 100 per cent, respectively.

Conclusion

The necessity of frozen section biopsy in cases with benign fine-needle aspiration cytology may be low in parotid gland surgery.

A 12-year-old boy presented with a three-month history of a painful parotid swelling. Fine needle aspiration cytology indicated a pleomorphic adenoma—an uncommon lesion in a child. This diagnostic technique plays a useful role in the investigation of head and neck swellings.

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Chapter 10 - Flow Cytometric Diagnosis of Classic Hodgkin Lymphoma in Lymph Nodes

Summary

The role of frozen section biopsy for parotid gland tumour with benign fine-needle aspiration cytology

Fine needle aspiration cytology of a head and neck swelling in a child: A non-invasive approach to diagnosis

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3 results

Chapter 10 - Flow Cytometric Diagnosis of Classic Hodgkin Lymphoma in Lymph Nodes

Summary

The role of frozen section biopsy for parotid gland tumour with benign fine-needle aspiration cytology

Fine needle aspiration cytology of a head and neck swelling in a child: A non-invasive approach to diagnosis