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1 results

  • D3 dopamine receptor mRNA expression in lymphocytes: a peripheral marker for schizophrenia?

  • J. van der Weide, L. S. W. Steijns, M. A. M. van der Geld, P. A. de Groot
  • Journal:
    Acta Neuropsychiatrica / Volume 15 / Issue 2 / April 2003
    Published online by Cambridge University Press:
    24 June 2014, pp. 91-93
  • Background:

    Identification of schizophrenia, a common neuropsychiatric disorder, is based on clinical examination. An easily measurable peripheral marker, which may enable a more rapid and more accurate diagnosis, is not available. A possible candidate is the D3 dopamine receptor on lymphocytes.

    Objective:

    The D3 receptor is investigated for its clinical significance as a marker for diagnosing schizophrenia.

    Methods:

    From eight schizophrenic patients and eight controls lymphocyte RNA was isolated. A semiquantitative reverse transcription–polymerase chain reaction (RT-PCR) was carried out and the intensities of the specific D3 dopamine receptor bands of patients and controls were compared.

    Results:

    No difference could be seen between the intensities of the bands from patients and controls.

    Conclusion:

    An aberrant D3 dopamine receptor mRNA expression in lymphocytes of schizophrenics could not be demonstrated. This might be caused by down-regulation of D3 receptor production by antipsychotic drug treatment. At present, the D3 receptor seems to have no diagnostic value in schizophrenia.