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The radical innovation design (RID) comparator is an unprecedented method for design comparison. It overcomes the limitations of traditional methods with a nuanced, structured approach that emphasizes detailed analysis over simple grading. At its core, the RID comparator employs a novel ontology based on the RID building blocks, enabling a precise alignment of activities and solutions. This alignment is deepened through the innovative “quantities of pain” metric, a tool that allows for a refined evaluation and comparison of solutions, facilitating the calculation of effectiveness indicators in a data-driven manner. The true impact of the method is demonstrated through an industrial use case on solutions for cleaning solar panels. The RID comparator demonstrates its practical efficacy in addressing complex, multifactorial design challenges, by constructing a cognitive model of the cleaning activity not only encapsulating the myriad aspects of the design problem but also generating a wealth of discussion and consensus-building among stakeholders. The resultant cognitive model serves as a pivotal tool in redefining the process of generating innovation briefs, deeply rooted in the actual needs and constraints of real-world scenarios. In essence, the RID comparator method significantly enhances the efficiency and quality of innovation processes, particularly in complex industrial contexts.
Major psychiatric disorders (MPDs) are delineated by distinct clinical features. However, overlapping symptoms and transdiagnostic effectiveness of medications have challenged the traditional diagnostic categorisation. We investigate if there are shared and illness-specific disruptions in the regional functional efficiency (RFE) of the brain across these disorders.
Methods
We included 364 participants (118 schizophrenia [SCZ], 80 bipolar disorder [BD], 91 major depressive disorder [MDD], and 75 healthy controls [HCs]). Resting-state fMRI was used to caclulate the RFE based on the static amplitude of low-frequency fluctuation, regional homogeneity, and degree centrality and corresponding dynamic measures indicating variability over time. We used principal component analysis to obtain static and dynamic RFE values. We conducted functional and genetic annotation and enrichment analysis based on abnormal RFE profiles.
Results
SCZ showed higher static RFE in the cortico-striatal regions and excessive variability in the cortico-limbic regions. SCZ and MDD shared lower static RFE with higher dynamic RFE in sensorimotor regions than BD and HCs. We observed association between static RFE abnormalities with reward and sensorimotor functions and dynamic RFE abnormalities with sensorimotor functions. Differential spatial expression of genes related to glutamatergic synapse and calcium/cAMP signaling was more likely in the regions with aberrant RFE.
Conclusions
SCZ shares more regions with disrupted functional integrity, especially in sensorimotor regions, with MDD rather than BD. The neural patterns of these transdiagnostic changes appear to be potentially driven by gene expression variations relating to glutamatergic synapses and calcium/cAMP signaling. The aberrant sensorimotor, cortico-striatal, and cortico-limbic integrity may collectively underlie neurobiological mechanisms of MPDs.
The activities of thermodynamic components of clay minerals corresponding in composition to pyrophyllite, muscovite, paragonite, and margarite were computed from chemical analyses reported in the literature assuming ideal mixing of atoms on homological sites in the minerals. These activities were then used to generate stability fields for smectites, illites, and mixed-layer clays on logarithmic activity diagrams representing equilibrium among minerals and aqueous solutions at 25°C and 1 bar. Comparative analysis indicates that the approach affords close approximation of both mineral and water compositions in geologic systems.
This final chapter shows how further enquiry into artefacts’ metaphysics forces us to return to artefacts’ physics. At the same time, this further enquiry is in turn shown to fall outside the interests of a metaphysician and to be the task of a natural philosopher. For this reason, the chapter looks at artefacts as objects of inquiry and distinguishes between perspective of the natural scientist, the maker, and the user on the one hand, and the perspective of the metaphysician on the other. This discussion allows us to wrap up the results, to reassess the relationship between the Physics and the Metaphysics, and to evaluate the respective contributions of these works to Aristotle’s ontology of artefacts.
Magnetic active regions on the Sun are harbingers of space weather. Understanding the physics of how they form and evolve will improve space weather forecasting. Our aim is to characterise the surface magnetic field and flows for a sample of active regions with persistent magnetic bipoles prior to emergence. We identified 42 emerging active regions (EARs), in the Solar Dynamics Observatory Helioseismic Emerging Active Region survey (Schunker et al. 2016, A&A. 595, A107), associated with small magnetic bipoles at least one day before the time of emergence. We then identified a contrasting sample of 42 EARs that emerge more abruptly without bipoles before emergence. We computed the supergranulation-scale surface flows using helioseismic holography. We averaged the flow maps and magnetic field maps over all active regions in each sample at each time interval from 2 d before emergence to 1 d after. We found that EARs associated with a persistent pre-emergence bipole evolve to be, on average, lower flux active regions than EARs that emerge more abruptly. Further, we found that the EARs that emerge more abruptly do so with a diverging flow of $(3\pm 0.6) \times 10^{-6}$ s$^{-1}$ on the order of 50–100 ms$^{-1}$. Our results show that there is a statistical dependence of the surface flow signature throughout the emergence process on the maximum magnetic flux of the active region.
The study’s focus on the modulation of geomagnetism by low latitude solar magnetically activity, including coronal mass ejections (CMEs), solar flares, and solar energetic particles (SEPs). It mentions the Babcock–Leighton (B-L) dynamo model used to predict sunspot numbers in Solar Cycle 25 (SC25) and highlights the challenges in understanding aspects such as the regeneration of the poloidal field and the occurrence of magnetic regions, active longitudes, and coronal holes. The abstract introduces the study’s concentration on the activity of polar regions using chromosphere jets activity proxies and other parameters like polar faculae density and cool ejection events. It also mentions the observation of chromospheric prolateness during the minimum solar activity periods.
We need theories that help us join the struggle for alternative futures. Cultural-historical approaches frame agency as something people do rather than something they have or sense. Building on this, I conceptualise agency in terms of the direction and reach of actions. Direction concerns movement from distinctive subject positionings towards desired endpoints. Reach concerns the extent of this movement. Direction and reach can be both outward (transforming the world) and inward (transforming the self). This acknowledges individuals’ contributions to changing their own lives and those of others without evacuating actions from the activities in which they are embedded. Motive, mediation, and motion are key to this. I illustrate these ideas in relation to existing research on young people’s environmental activism, a Latino boy in foster care, and a mother struggling to care for her infant child, as well as examples from prior research and other chapters in this volume.
Edited by
Alexandre Caron, Centre de Coopération Internationale en Recherche Agronomique pour le Développement (CIRAD), France,Daniel Cornélis, Centre de Coopération Internationale en Recherche Agronomique pour le Développement (CIRAD) and Foundation François Sommer, France,Philippe Chardonnet, International Union for Conservation of Nature (IUCN) SSC Antelope Specialist Group,Herbert H. T. Prins, Wageningen Universiteit, The Netherlands
African buffalo herd size varies across their distribution range from as few as 5–10 in the rainforests of West and Central Africa to as many as 2000 individuals in the floodplains of eastern and southern Africa. The home range size of African buffalo also varies greatly, with those of savanna buffalo herds generally ranging between 50 and 350 km2. The larger home ranges are generally observed in areas where resources are spatially segregated, and where herds are forced to undertake seasonal movements. In contrast, forest buffalo exhibit smaller home ranges (<10 km2) due to a less pronounced seasonality of the environment, and a more homogeneous spatial arrangement of resources. African buffalo are ruminants, essentially feeding on grass and roughage. This species is capable of subsisting on pastures too coarse and too tall for most other herbivores. The African buffalo occupies an important niche, opening up habitats that are preferred by short-grass grazers. Although the African buffalo primarily is a grazer, savanna buffalo can partially switch their diet to browse when grasses become tall and lignified. The ability of the African buffalo to cope with contrasting environmental conditions throughout most sub-Saharan ecosystems, by modulating a large array of biological traits, highlights a high degree of behavioural plasticity.
Actions are not merely what we do but essentially connected with intentionality, particularly beliefs and intentions, and thereby with the will. Some actions are basic; others we do by doing something basically – “at will.” Act-types are the kind of thing we can exemplify repeatedly or multiple agents can exemplify simultaneously, say speaking. Act-tokens are individual actions tied to a particular agent, time, and mode of performance. Ethics must address both: types as contents of intentions and primary indicators of obligations, and tokens as morally significant in ways that, like their underlying motives, are not fixed by their type. This chapter also clarifies control of action, direct and indirect. It is not just basic acts that are under direct voluntary control; most of the salient manners of our actions are. Moral obligation and moral responsibility for action extend to those as well as to the acts they color – or discolor.
Common marmosets, Callithrix jacchus, are widely used by research laboratories and are commonly provided with food in bowls. These centralised, unchallenging sources of food result in high foraging success for low foraging effort. Foraging devices, which require more skill and effort for foraging success, may broaden the behavioural profiles of marmosets by including more elements of their natural ethogram, reflecting improved welfare. The behaviour of eight female common marmosets was examined as a function of four different food distributions: food centrally located in a stationary bowl; food in a bowl that changed location each day; food centrally located in a stationary bowl, in addition to hidden food in a clustered food source (cluster feeder) or hidden food in dispersed food sources (dispersed feeders). Both the cluster and dispersed feeder distributions increased foraging, and there was a trend for reduced scratching and grooming in the presence of the feeders compared with the bowl-only treatments. The cluster feeder increased the amount of time a marmoset spent in a large room annexed to the home rooms more than the dispersed feeders, and this effect was sustained throughout the day after the feeders had been removed. Both feeders increased activity and movements within all areas of the annexed room compared with the bowl-only treatments; therefore, both feeder types improved the welfare of the captive marmosets more than the provision of food bowls.
Chimpanzees (Pan troglodytes) that are kept in captivity come from a wide variety of backgrounds, and a proportion of them have been subjected to maternal separation and social deprivation during development. The long-term effects of such practices have received little investigation. This study investigates whether the removal of infants from their mothers and/or other chimpanzees affects their activity levels and abnormal behaviours later in life. A total of 69 resocialised chimpanzees were studied at six zoos in the United Kingdom. Chimpanzees were categorised into one of three rearing conditions: reared by their mother in a group of conspecifics (MGR); reared with other conspecifics but separated from their mothers (RO); and reared apart from their mother or other conspecifics for a period of time during infancy (RA). Results indicate that ‘socially deprived’ individuals show reduced levels of normal activity, elevated levels of abnormal behaviours and a wider repertoire of abnormal behaviours. These differences were more pronounced in younger individuals, with adults from the three different rearing conditions performing abnormal behaviour patterns at comparable levels. It is concluded that human-rearing, either alone or with conspecifics, influences behaviour through suppression of normal activity levels as a result of separation and elevation of levels of abnormal behaviours as a mechanism for coping with maternal loss and restricted rearing. However, these effects are not irreversible and recovery of ‘normal’ behaviours may occur with access to an enriched social environment.
Ferric heme b (= ferric protoporphyrin IX = hemin) is an important prosthetic group of different types of enzymes, including the intensively investigated and widely applied horseradish peroxidase (HRP). In HRP, hemin is present in monomeric form in a hydrophobic pocket containing among other amino acid side chains the two imidazoyl groups of His170 and His42. Both amino acids are important for the peroxidase activity of HRP as an axial ligand of hemin (proximal His170) and as an acid/base catalyst (distal His42). A key feature of the peroxidase mechanism of HRP is the initial formation of compound I under heterolytic cleavage of added hydrogen peroxide as a terminal oxidant. Investigations of free hemin dispersed in aqueous solution showed that different types of hemin dimers can form, depending on the experimental conditions, possibly resulting in hemin crystallization. Although it has been recognized already in the 1970s that hemin aggregation can be prevented in aqueous solution by using micelle-forming amphiphiles, it remains a challenge to prepare hemin-containing micellar and vesicular systems with peroxidase-like activities. Such systems are of interest as cheap HRP-mimicking catalysts for analytical and synthetic applications. Some of the key concepts on which research in this fascinating and interdisciplinary field is based are summarized, along with major accomplishments and possible directions for further improvement. A systematic analysis of the physico-chemical properties of hemin in aqueous micellar solutions and vesicular dispersions must be combined with a reliable evaluation of its catalytic activity. Future studies should show how well the molecular complexity around hemin in HRP can be mimicked by using micelles or vesicles. Because of the importance of heme b in virtually all biological systems and the fact that porphyrins and hemes can be obtained under potentially prebiotic conditions, ideas exist about the possible role of heme-containing micellar and vesicular systems in prebiotic times.
Fast-growing broiler chickens use pen-space heterogeneously and have low activity levels, related in part to leg problems. The aim of this study was to test the effects of the addition of string and sand trays to rearing pens on the use of space, levels of activity and leg problems. Broiler chickens were reared in 12 pens (40 birds per pen). Drinkers and feeders only were present in the six control pens (C group), whereas the six other pens were enriched (E group) with two sand trays and string. Behaviour was recorded by scan and focal sampling on days 2-3, 13-14, 23-24 and 34-35. Bodyweight, the occurrence of tarsal deformities and the composition of tibiotarsi were measured on day 37. Chickens from the E group spent more time and stood more often in the area enriched with sand than did the g group birds. ghickens in the E group foraged in the sand throughout the rearing period, and their foraging activities were greater than those of the C group birds. They had little interest in the strings. Locomotor activity during standing bouts was enhanced in the E group on days 2-3 only. Bodyweight at day 37, the occurrence of tarsal deformities and the composition of tibiotarsi were not significantly different between groups. These results indicate that sand could attract chickens into areas that are usually rarely used, which may reduce problems resulting from their heterogeneous distribution. However, the results also indicate the difficulty of stimulating locomotion.
Accelerometers are used to remotely monitor activity in various species in studies that quantify pain, document behavioural patterns, and measure individual activity differences. Studies validating accelerometers typically quantify various active states; however, targeting states specific to periods of inactivity, such as sitting, sleeping, and standing, has the potential to more accurately quantify inactive behaviours commonly associated with behavioural changes related to pain, sickness, or injury. Our objectives were two-fold: first, validate a commercially available accelerometer (Actical®) for quantifying inactivity in laying hens and, second, compare inactivity levels between hens with severely fractured keel bones and hens with minimal to no keel damage. Correlation between the inactivity level as measured by the accelerometer compared to live, focal observation of stationary, inactive behaviours was high; therefore, the Actical® accurately quantifies inactive states in laying hens. Following validation, the Actical® accelerometer was used to quantify inactivity level differences between hens with or without keel-bone damage. Severely fractured hens spent less time motionless, than hens with minimal to no keel damage. Further investigation into inactivity differences related to keel status before and after acquisition of keel fractures is warranted. Use of the accelerometer has the potential to improve animal welfare research by quantifying the effect of pain or sickness on activity level, mapping daily activity patterns, and measuring individual differences in general activity.
Chapter 6 discusses the daily activities of older hippies. By exploring what they currently do for fun and comparing it with their past leisure activities, this chapter explores patterns of continuity and change in practice and meaning. It also suggests that the hippies diverse leisure repertoires and ethics of play significantly contribute to their wellbeing in later life.
The final chapter discusses whether or not hippies age differently or better than other older adults.It suggests two complementary perspectives: The perceptions of the researched individuals that emphasize healthy lifestyle, engagement, and social support; and the researcher’s viewpoint, which stresses identity work, generativity, play, spirituality, and psychological sense of community. Discussing the two overarching themes of ideology and adaptability, the chapter also presents a take-home message about commitment and its contribution to wellbeing in old age. Overall, it suggests that we and others may benefit if we make our later years meaningful, satisfying, and hippie to an extent.
The study was aimed to evaluate the effect of tumour involvement on resin Yttrium-90 (Y90) activity determination for metastatic liver cancer treatment.
Methods:
One hundred and two cases of resin Y90 microsphere treatment were retrospectively studied. Body surface area (BSA) method was used in the calculation of resin Y90 activity. The total activity (TA) was calculated as a summation of activities obtained from BSA-based calculation and tumour involvement (TI). TI and TA of each case were evaluated. The contributions of TI to TA were calculated with the ratio of TI/TA.
Results:
The average contribution of TI to TA was 4·1%. The contributions were < 5·8% in 75% of the cases, < 2·2% in 50% of the cases and < 1·0% in 25% of the cases.
Conclusions:
Overall the effect of tumour involvement on the activity determination was small. The activity calculation could be simplified by neglecting TI in 25% of the cases where the activity contribution from TI was less than 1%. Contouring tumour and liver structures for TI calculation could be avoided in these cases, and the efficiency of the workflow for resin Y90 procedures could be improved.
The implementation of undergraduate research in music is occurring at many institutions as an expansion and renaming of a wide variety of creative activities that heretofore have not been labeled as research. A rapidly increasing number of examples exist around the world, and these can serve as models for future projects and programs. What is needed now is the implementation, adaptation, improvement, and assessment of these models so that all music students have such opportunities. Many other disciplines have a long history of such activity.
TBT-S utilizes multiple intervention strategies to apply TBT-S principles. These strategies have been developed and adapted over a 10-year period through iteratively integrating client and Support feedback with research findings in the treatment development process to increase accuracy and acceptability. The interventions are (1) neurobiological psychoeducation, (2)experiential learning addressing AN neurobiology and traits for problem-solving activities for clients and Supports, (4) client and Support skills training, (5) meal coaching, and (6) The TBT-S Behavioral Agreement.
In the nineteenth century, visual culture became noted for spectacles such as panoramas, which sought to create an experience that offered more than simply viewing an engraving or a framed painting. The panorama placed the spectator at the centre of a circle, surrounded by a huge painting on a curved surface. This chapter focuses on the Arctic panorama Summer and Winter Views of the Polar Regions (1850) that opened in London in 1850. The chapter explains how a radically transformed Arctic was presented to a metropolitan audience, which anticipated education, entertainment, and an aesthetic experience at Leicester Square, London. Summer and Winter Views was based on the drawings of a recently returned officer, William Henry Browne, and made claims of authenticity in a competitive market. By closely reading the sources available for the panorama, including sketches, contemporary reviews, and prints, it argues that this affordable and persuasive spectacle of ‘savage horrors’ transformed the Arctic into a supernatural space of well-executed, yet sensationalistic, Gothic icescapes, masculine endeavour, and exotic meteorological effects.