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Attention-deficit hyperactivity disorder (ADHD) in adults attending addiction treatment in Ireland: preliminary international ADHD in substance-use disorders prevalence study (IASP) results

Published online by Cambridge University Press:  29 May 2013

M. C. Van Hout*
Affiliation:
Lecturer, School of Health Sciences, Waterford Institute of Technology, Waterford, Ireland
M. Foley
Affiliation:
Researcher, School of Health Sciences, Waterford Institute of Technology, Waterford, Ireland
*
*Address for correspondence: M. C. Van Hout, School of Health Sciences, Waterford Institute of Technology, Waterford, Ireland. (Email mcvanhout@wit.ie)
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Abstract

Objectives

Attention-deficit hyperactivity disorder (ADHD) is a neuro-behavioural disorder characterised by early onset of persistent inattention–disorganisation and hyperactivity–impulsivity. Symptoms causing significant impairment in psychosocial function commence in childhood and heighten the risk for early substance experimentation and potential development of substance-use disorders (SUD). The research aimed to estimate the occurrence of adult attention-deficit hyperactivity disorder (ADHD) in new treatment cases of adults attending addiction treatment services.

Methods

The Adult ADHD Symptoms Rating Scale (ASRS) self-administered questionnaire was administered on entry and 2 weeks later for first admissions to inpatient and outpatient addiction treatment settings The ASRS is a validated and reliable 18-item self-report scale derived from the DSM-IV-TR diagnostic criteria for ADHD, comprising nine items on inattention and nine items on hyperactivity/impulsivity.

Results

A total of 47 new treatment cases took part in the study. The occurrence of ADHD among SUDs in this sample was 13% (n = 6). Four of the participants were being treated for Problem Poly Substance use, whereas two participants were being treated for Problem Drug use. None of the participants screening positive for ADHD were being treated for Problem Alcohol use. Of the positively screened cases, all were male, predominantly single and unemployed.

Conclusions

The ASRS screening instrument may be a useful tool to detect ADHD co-morbidity in SUD treatment-seeking cases. More research is needed to appropriately develop the SUD treatment pathways for adolescent and adult ADHD sufferers in Ireland.

Type
Original Research
Copyright
Copyright © College of Psychiatrists of Ireland 2013 

Introduction

Attention-deficit hyperactivity disorder (ADHD) is a neuro-behavioural disorder characterised by early onset of persistent inattention–disorganisation and hyperactivity–impulsivity causing significant impairment in executive and psychosocial function, with commencement during childhood, and with symptoms persisting into adulthood in up to 50% of patients (Fitzgerald, Reference Fitzgerald1998, Reference Fitzgerald2005; American Psychiatric Association, 2000; Biederman, Reference Biederman2005; Arias etal. Reference Arias, Gelernter, Chan, Weiss, Brady, Farrer, Farrer and Kranzler2008; Lee etal. Reference Lee, Humphreys, Flory, Liu and Glass2011; Castells etal. Reference Castells, Ramos-Quiroga, Bosch, Nogueira and Casas2011a). Global estimates of lifetime prevalence of childhood ADHD in the general population range between 5% and 12%, with ∼1–6% of adults (with average rates of 3–4%) having adult ADHD in the general population (Meltzer etal. Reference Meltzer, Gatward, Goodman and Ford2000; Scahill & Schwab-Stone Reference Scahill and Schwab-Stone2000; Lynskey & Hall, Reference Lynskey and Hall2001; Sullivan & Rudnik-Levin, Reference Sullivan and Rudnik-Levin2001; Wender etal. Reference Wender, Wolf and Wasserstein2001; Faraone etal. Reference Faraone, Sergeant, Gillberg and Biederman2003; Wilens, Reference Wilens2004; Kalbag & Levin, Reference Kalbag and Levin2005; Kessler etal. Reference Kessler, Adler, Barkley, Biederman, Conners and Demler2005, Reference Kessler, Adler, Barkley, Biederman, Conners, Faraone, Greenhill, Howes, Secnik, Spencer, Ustun, Walters and Zaslavsky2006; Fayyad etal. Reference Fayyad, De Graaf, Kessler, Alonso, Angermeyer, Demyttenaere, De Girolamo, Haro, Karam, Lara, Lepine, Ormel, Posada-Villa, Zaslavsky and Jin2007; Polanczyk & Rohde, Reference Polanczyk and Rohde2007). In Ireland, prevalence rates of ADHD in young Irish adolescents are similar to other western cultures (1–5%) (Kirley & Fitzgerald, Reference Kirley and Fitzgerald2002; Lynch etal. Reference Lynch, Mills, Daly and Fitzpatrick2006). Some Irish research has estimated the prevalence of ADHD in adult outpatient psychiatric patients to be close to 24%, with 56% reported as female and average age of 42.5 years (Syed etal. Reference Syed, Masaud, Nkire, Iro and Garland2010). The diagnosis of childhood ADHD is viewed as reliable and valid, with the validity of adult ADHD being somewhat complicated (Kirley & Fitzgerald, Reference Kirley and Fitzgerald2002). Research is suggestive of continued and underestimated expression of the disorder tracking into adulthood (Biederman etal. Reference Biederman, Farone, Milberger, Curtis, Chen, Marrs, Oeullette, Moore and Spencer1996; Barkley etal. Reference Barkley, Fischer, Smallish and Fletcher2002). Many adults with ADHD remain undiagnosed (Fitzgerald, Reference Fitzgerald2001). Rates of persistence of ADHD symptoms into adulthood vary between 50% and 80% cases (Fitzgerald, Reference Fitzgerald1998, Reference Fitzgerald2005; Kirley & Fitzgerald, Reference Kirley and Fitzgerald2002). Syed etal. (Reference Syed, Masaud, Nkire, Iro and Garland2010) in their Irish study reported significant underdiagnosis of ADHD, with no patients reporting a recorded diagnosis of adult ADHD.

ADHD is associated with a myriad of coexisting impairments such as mood instabilities (depression and anxiety), disruptive behaviours (oppositional defiant disorder, conduct disorders and Cluster-B personality disorders), neuro-psychological impairments (attention span, memory and concentration), family problems (family conflict and negative parental relations), academic problems (poor educational attainment and early school leaving), occupational underachievement (inability to attend school or university, although IQ is often higher than average) and social dysfunction (peer difficulties, impulsivity and anti-social behaviours) in both boys and girls, and identifiable from pre-school age (Kalbag & Levin, Reference Kalbag and Levin2005; Hinshaw etal. Reference Hinshaw, Owens, Sami and Fargeon2006; Lee etal. Reference Lee, Lahey, Owens and Hinshaw2008; Owens etal. Reference Owens, Hinshaw, Lee and Lahey2009; Biederman etal. Reference Biederman, Petty, Monuteaux, Fried, Byrne, Mirto, Spencer, Wilens and Faroane2010; Lee etal. Reference Lee, Humphreys, Flory, Liu and Glass2011; Castells etal. Reference Castells, Ramos-Quiroga, Bosch, Nogueira and Casas2011a).

Of interest for this research report is that ADHD symptoms can influence child and adolescent substance use by way of earlier ages of onset for difference substances, higher rates of use, displacements towards more serious forms of drug use, poly-substance use, increase addictive potential and pathways towards substance-use disorder (SUD) (Sullivan & Rudnik-Levin, Reference Sullivan and Rudnik-Levin2001; Davids & Gastpar, Reference Davids and Gastpar2003; Molina etal. Reference Molina, Marshal, Pelham and Wirth2005). Children of substance-abusing adults have a greater likelihood to develop ADHD, with problematic substance use frequently reported in households and from parents of children with ADHD (Chronis etal. Reference Chronis, Lahey, Pelham, Kipp, Baumann and Lee2003; Clarke & Fitzpatrick, Reference Clarke and Fitzpatrick2005). A co-occurring ADHD diagnosis is associated with heightened risk for substance experimentation, earlier onset of alcohol and drug use and a more serious trajectory of substance misuse and related problems (Biederman, 2000, Reference Biederman, Monuteaux, Mick, Spencer, Wilens, Silva, Snyder and Faroane2005); Charach etal. Reference Charach, Yeung, Climans and Lillie2011; Wilens etal. Reference Wilens, Martelon, Joshi, Bateman, Fried, Petty and Biederman2011; van Emmerik-van Oortmerssen etal. Reference van Emmerik-van Oortmerssen, van de Glind, van den Brink and Smit2012). ADHD and SUDs are proposed to share common genetic risk factors, similar personality, psychosocial and environmental factors, and may co-occur because of individual ‘self-medication’ of ADHD symtomatologies (Kalbag & Levin, Reference Kalbag and Levin2005) and equally as a result of difficulties incurred when early diagnosis and treatment do not occur, in terms of peer and school rejection, and association with anti-social peers engaging in substance misuse and/or criminal activity (Syed etal. Reference Syed, Masaud, Nkire, Iro and Garland2010). Quite commonly, adult ADHD cases with SUD describe an undiagnosed parent suffering with ADHD themselves and may experience substance misuse in the home.

In addition, when co-occurring with other common psychiatric disorders such as oppositional defiant disorder, conduct disorder and anti-social personality disorder, SUD trajectories and clinical outcomes are further complicated (Arias etal. Reference Arias, Gelernter, Chan, Weiss, Brady, Farrer, Farrer and Kranzler2008; Lee etal. Reference Lee, Humphreys, Flory, Liu and Glass2011). Adolescents with ADHD are more likely to smoke cigarettes, with cigarette smoking being associated with the development of adult SUD (Wilens & Upadhyaya, Reference Wilens and Upadhyaya2007). Prevalence of childhood and adult ADHD in those with SUDs are approximately one in five, but have been recorded as high as 83% (Sullivan & Rudnik-Levin, Reference Sullivan and Rudnik-Levin2001; Davids & Gastpar, Reference Davids and Gastpar2003; Kalbag & Levin, Reference Kalbag and Levin2005; Matsumoto etal. Reference Matsumoto, Kamijo, Yamaguchi, Iseki and Hirayasu2005; Wilens & Fusillo, Reference Wilens and Fusillo2007; Arias etal. Reference Arias, Gelernter, Chan, Weiss, Brady, Farrer, Farrer and Kranzler2008). SUD prevalence among the adult ADHD cohorts has been recorded as high as 35% (Kalbag & Levin, Reference Kalbag and Levin2005; Wilens & Upadhyaya, Reference Wilens and Upadhyaya2007). Irish data have recorded 11% of adult ADHD cases diagnosed with SUD (Syed etal. Reference Syed, Masaud, Nkire, Iro and Garland2010).

The treatment of childhood ADHD with stimulant medication (i.e. methylphenidate or atomoxetine) and the timing of such treatment, its mediation by the presence of other co-morbid conditions and its relationship with the development of future problematic substance use remains questionable (Lee etal. Reference Lee, Humphreys, Flory, Liu and Glass2011; Castells etal. Reference Castells, Ramos-Quiroga, Bosch, Nogueira and Casas2011a). Diversionary use of stimulant medication is of concern particularly among adolescents and young adults (Wilens & Fusillo, Reference Wilens and Fusillo2007). In terms of SUD treatment outcomes, the presence of ADHD is associated with higher relapse rates, with the stimulant treatment of ADHD not as effective in those with SUD (Carpentier etal. Reference Carpentier, de Jong, Dijkstra, Verbrugge and Krabbe2005; Levin etal. Reference Levin, Evans, Brooks and Garawi2006, Reference Levin, Evans, Brooks, Kalbag, Garawi and Nunes2007; Konstenius etal. Reference Konstenius, Jayaram-Lindström, Beck and Franck2010; Thurstone etal. Reference Thurstone, Riggs, Salomonsen-Sautel and Mikulich-Gilbertson2010; Castells etal. Reference Castells, Ramos-Quiroga, Rigau, Bosch, Nogueira, Vidal and Casas2011b). Research highlights the lack of clear effect of medication treatment on substance use (van Emmerik-van Oortmerssen etal. Reference van Emmerik-van Oortmerssen, van de Glind, van den Brink and Smit2012), with the exception of a study on cocaine-dependent ADHD patients receiving methylphenidate, whereby the reduction in ADHD symptoms was associated with reduced cocaine use, a typically impulsive form of drug-taking behaviour (Levin etal. Reference Levin, Evans, Brooks, Kalbag, Garawi and Nunes2006). Furthermore, ADHD symptoms such as inattention and impulsivity negatively affect treatment engagement, retention and outcomes and, because of symptom overlap, are not easily distinguishable from other psychiatric disorders or the symptoms of drug intoxication or withdrawal (Wilens & Upadhyaya, Reference Wilens and Upadhyaya2007; van Emmerik-van Oortmerssen etal. 2011; Matthies etal. Reference Matthies, Philipsen and Svaldi2012). Goossensen etal. (Reference Goossensen, van de Glind, Carpentier, Wijsen, van Duin and Kooij2006) have underscored the need to develop standardised protocols for the screening, diagnosis and treatment of ADHD in patients with SUD. In Ireland, as elsewhere, addiction treatment services may lack the expertises necessary for the screening, diagnosis and treatment of ADHD in SUD patients (Edokpolo etal. Reference Edokpolo, Nkire and Smyth2010).

This research report shall present preliminary findings relating to the occurrence of ADHD in new addiction treatment cases agreeing to partake in the study using the Adult ADHD Symptoms Rating Scale (ASRS-v1.1) (Van den Brink, Reference Van den Brink2012). The study was undertaken as part of the multi-site International ADHD in Substance Use Disorders Prevalence Study (IASP) directed by the International Collaboration on ADHD and Substance Abuse (ICASA) network. Eight European countries (Norway, Sweden, the Netherlands, Belgium, France, Spain, Switzerland and Hungary), United States and Australia participated in Phase II (closing in September 2011), with Ireland partaking in Phase II alongside South Africa, Egypt and Brazil.

MethodologyThe research was guided and sanctioned by the terms of reference of the Waterford Institute of Technology and Regional Health Service Executive (HSE) Research Ethics Committees, Ireland (January 2012). Addiction counsellors from participating outpatient and inpatient treatment settings in the South East region attended an in-depth IASP study protocol and assessment tool training course, provided by an experienced researcher from the ICASA network in November 2011. Following this training, adult ‘new treatment cases’ presenting to four treatment settings in the South East region (with the exception of those presenting with visible intoxication) were invited to participate. Those agreeing to participate were provided with an information leaflet detailing the study, confidentiality procedures and rights to withdraw. All participants were required to complete an informed consent form before participation.

Participants were asked to complete the self-report ASRS-v1.1 questionnaire, plus a demographic section including basic information about their problematic substance use. The ASRS is an 18-item self-report scale derived from the DSM-IV-TR diagnostic criteria for ADHD, comprising nine items on inattention and nine items on hyperactivity/impulsivity. It is widely used and has been validated in the Phase I IASP Studies for use ‘at the front door’ of treatment entry (Van den Brink, Reference Van den Brink2012), with a six-item ASRS screener shown to outperform the full version. For example, if four of these six items are endorsed, it indicates that the respondent has symptoms highly consistent with ADHD in adults and further investigation is warranted. Following a 2-week period of abstinence, participants were invited to complete the ASRS screener at a second time interval to screen for ADHD in the absence of obvious withdrawal symptoms and before the achievement of stable abstinence (Van den Brink, Reference Van den Brink2012). Data were analysed using PASW version 18 statistical software.

Results

A total of 49 treatment-seeking people agreed to take part in the study. Two participants did not partake in screening phase at the second time interval, leaving a total population of 47 participants having completed at time one and time two intervals. Thirty-four men and 13 women took part, with 33 Caucasian and the remainder undisclosed. The median age of the sample was 36 years. A majority were single (n = 34) with five married, four in a relationship, three separated and one widowed. Of the participants, 30 were unemployed, with eight in employment, two retired and one in receipt of disability allowance. A further six declined to indicate. Seventeen participants were engaged in treatment for Problematic Poly Substance use, followed by 14 in treatment for Problematic Alcohol use and 14 in treatment for Problematic Drug use. Table 1 shows the demographic details of the participants.

Table 1 Demographic participant details

A total of 10 participants screened positive at time one and this reduced to six participants at the time two interval. This indicates the occurrence of ADHD in these SUD patients was 13% (n = 6). Of the ADHD-positive cases at both time intervals, 100% (n = 6) were Caucasian and Male and had a median age of 23 years. Five were single, with one participant indicating that they were currently in a relationship. Five were unemployed. Four of the participants were being treated for Problem Poly Substance use, whereas two were being treated for Problem Drug use (opiates). None of the participants screening positive for ADHD were being treated for Problem Alcohol use.

Discussion

The IASP study Phase-I results indicate estimates of the prevalence of ADHD in treatment-seeking adults for SUD at between 20 and 25%. (Van den Brink, Reference Van den Brink2012). This preliminary Phase-II study indicates that 13% of adults seeking treatment for SUD were detected to screen positive for ADHD, with findings supporting the usefulness and cost-effectiveness of the ASRS to detect ADHD co-morbidity in SUD patients in addiction treatment settings. Similar to other existing Irish research (Syed etal. Reference Syed, Masaud, Nkire, Iro and Garland2010), none had received a confirmed diagnosis of childhood ADHD by a psychiatrist. There are only two dedicated Adult ADHD clinics in Ireland, with the public sector in Ireland not currently providing specialist clinics for the assessment and diagnosis of adult ADHD. The findings, although small scale and restricted by virtue of convenience sampling, are intended to fuel debate on the current situation in Ireland and useful to guide development of programmes to detect, diagnose and manage ADHD in those with SUD, contribute to improved and effective treatment of SUD in patients with co-morbid ADHD and inform strategies for the prevention and monitoring of SUD in children with ADHD in Ireland.

The participants screening positive for ADHD reported problem drug use. It is noteworthy that Irish psychiatric treatment statistics indicate an increase in the rate of drug-related first admissions, with a decrease in admissions to psychiatric facilities with an alcohol disorder (Daly and Walsh, Reference Daly and Walsh2010). However, this may have been because of the recent increase in the provision of community-based specialised addiction services in the reporting timeframe. Despite this, trends in first admissions for problematic alcohol use and prevalence of alcohol as primary problematic substances in addiction treatment services have increased in recent years (Carew etal. Reference Carew, Bellerose and Lyons2011). This indicates that dependence on alcohol (and indeed drugs) requires repeated treatment cycles. In addition, almost one in five alcohol-dependent treatment patients reported using at least one other substance, with common secondary substances of choice for use alongside alcohol, reportedly cannabis, cocaine, benzodiazepines and ecstasy, and indicating a shift away from opiates as a common additional drug (Carew etal. Reference Carew, Bellerose and Lyons2011). It should be noted that poly-substance use and associated problems increase the complexity of treatment and contribute to poorer outcomes (Carew etal. Reference Carew, Bellerose and Lyons2011). Trends in treated problem drug use also indicate a rise in prevalence, with opiates as the most common primary problem drug overall, and with first admissions reporting cannabis as a common main problem drug ahead of opiates in 2010 (Bellerose etal. Reference Bellerose, Carew and Lyons2011). This data series also reports on concerning increases in benzodiazepine misuse among first admissions, and a majority of cases reporting problem use of more than one substance (Bellerose etal. Reference Bellerose, Carew and Lyons2011). Similar to the sample profile in this study, drug treatment cases are predominantly male and in their 20s (Bellerose etal. Reference Bellerose, Carew and Lyons2011).

It should be noted that several pitfalls were identified in conducting this preliminary IASP study, which to date had not been undertaken in Ireland. Recruitment of treatment settings was problematic because of a lack of interest in ADHD, lack of time and staff work overload. In addition, several treatment settings that agreed to partake and attended the IASP training subsequently failed to commit to fieldwork. This was attributed to change of management and lack of professional support of the study objectives. In participating sites, several ASRS manuals were returned incomplete, leading to exclusion from the data entry. The sample is additionally compromised by convenience bias, with no information available on the level of patient refusal to participate and numbers of first admissions who were not invited to participate because of the participating addiction counsellors’ perception of chaotic behaviour or intoxication.

Conclusion

The prevalence of adult ADHD in SUD patients remains unknown in Ireland. However, the economic and public health burden of SUDs is no doubt compounded by the presence of ADHD patients in the form of treatment reuptake, frequent relapse and subsequent draw on existing addiction treatment resources. One cannot discount that the core symptoms of ADHD contribute to substance-related risk taking, and vice versa, the chosen substance(s) contribute to adverse affects of these symptoms. This contributes to serious forms of substance use, dependence and subsequent treatment failures (Sullivan & Rudnik-Levin, Reference Sullivan and Rudnik-Levin2001; Arias etal. Reference Arias, Gelernter, Chan, Weiss, Brady, Farrer, Farrer and Kranzler2008; Lee etal. Reference Lee, Humphreys, Flory, Liu and Glass2011; Matthies etal. Reference Matthies, Philipsen and Svaldi2012). Irish research has commented on difficulties in treating addiction patients with ADHD diagnosis who frequently have their medication stopped once SUD occurs, with subsequent addiction treatment taking preference over that of ADHD (Edokpolo etal. Reference Edokpolo, Nkire and Smyth2010). Clinician concerns over diversion and abuse of prescribed medication, potential worsening of SUD and drug interaction between illicit and prescribed are also evident in Ireland (Edokpolo etal. Reference Edokpolo, Nkire and Smyth2010).

Despite these concerns, the timely diagnosis and intervening treatment of adult ADHD has the potential to positively affect addiction treatment outcomes, with the design of specific treatment pathways for individuals with ADHD and SUD much needed in Ireland. The ASRS screener is a useful, cost- and time-effective tool to detect ADHD co-morbidity in SUD patients and can be easily utilised by Irish addiction teams on treatment entry. Most importantly, the consideration of combined pharmacological and psychosocial interventions (cognitive behavioural therapy, motivational interviewing and family therapy), alongside the development of specialist mental health teams for adolescent and adult ADHD in Ireland, is central to the treatment success for co-morbid adults with ADHD and SUD (Goossensen etal. Reference Goossensen, van de Glind, Carpentier, Wijsen, van Duin and Kooij2006; Riggs etal. Reference Riggs, Levin, Green and Vocci2008; James etal. Reference James, Smyth and Apantaku-Olajide2013). Interventions promoting parental and teacher monitoring, drug education in schools and early interventions assessing, diagnosing and targeting childhood ADHD symptoms have the potential combined to reduce future SUD trends and subsequent treatment service uptakes (van Emmerik-van Oortmerssen etal. Reference van Emmerik-van Oortmerssen, van de Glind, van den Brink and Smit2012). These strategies will have positive impact on the public mental health and addiction service provisions in Ireland.

Acknowledgements

The authors thank Geurt van de Glind, The International Collaboration on ADHD and Substance Abuse (ICASA) Trimbos Institute, Utrecht, The Netherlands, and Rose Kavanagh, Irish National Council of Attention-Deficit Hyperactive Disorder of Support Groups (INCADDS).

Conflict of Interest

None.

References

American Psychiatric Association (2000). Diagnostic and Statistical Manual of Mental Disorders, 4th edn. American Psychiatric Association: Washington, DC.Google Scholar
Arias, AJ, Gelernter, J, Chan, G, Weiss, RD, Brady, KT, Farrer, L, Farrer, L, Kranzler, HR (2008). Correlates of co-occurring ADHD in drug-dependent subjects: prevalence and features of substance dependence and psychiatric disorders. Addictive Behaviours 33, 11991207.CrossRefGoogle ScholarPubMed
Barkley, R, Fischer, M, Smallish, L, Fletcher, K (2002). The persistence of attention-deficit/hyperactivity disorder into young adulthood as a function of reporting source and definition of disorder. Journal of Abnormal Psychology 111, 279289.CrossRefGoogle ScholarPubMed
Bellerose, D, Carew, AM, Lyons, S (2011). Trends in treated problem drug use in Ireland 2005–2010. HRB Trends Series 12. Health Research Board: Dublin.Google Scholar
Biederman, J (2005). Attention-deficit/hyperactivity disorder: a selective overview. Biological Psychiatry 57, 12151220.CrossRefGoogle ScholarPubMed
Biederman, J, Farone, S, Milberger, S, Curtis, S, Chen, L, Marrs, A, Oeullette, , Moore, P, Spencer, T (1996). Predictors of persistence and remission of ADHD into adolescence: results from a four-year prospective follow-up study. Journal of the American Academy of Child & Adolescent Psychiatry 35, 343351.CrossRefGoogle ScholarPubMed
Biederman, J, Monuteaux, MC, Mick, E, Spencer, T, Wilens, TE, Silva, JM, Snyder, LE, Faroane, SV (2000). Young adult outcome of attention deficit hyperactivity disorder: a controlled 10-year follow-up study. Psychological Medicine 36, 167179.CrossRefGoogle Scholar
Biederman, J, Petty, CR, Monuteaux, MC, Fried, R, Byrne, D, Mirto, T, Spencer, T, Wilens, T, Faroane, SV (2010). Adult psychiatric outcomes of girls with attention deficit hyperactivity disorder: 11-year follow-up in a longitudinal case-control study. American Journal of Psychiatry 167, 409417.CrossRefGoogle Scholar
Carew, AM, Bellerose, D, Lyons, S (2011). Trends in treated problem alcohol use in Ireland 2005 to 2010. HRB Trends Series 11. Health Research Board: Dublin.Google Scholar
Carpentier, PJ, de Jong, CA, Dijkstra, BA, Verbrugge, CA, Krabbe, PF (2005). A controlled trial of methylphenidate in adults with attention deficit/hyperactivity disorder and substance use disorders. Addiction 100, 18681874.CrossRefGoogle ScholarPubMed
Castells, X, Ramos-Quiroga, JA, Bosch, R, Nogueira, M, Casas, M (2011a). Amphetamines for attention deficit hyperactivity disorder (ADHD) in adults. Cochrane Database Systematic Review 6 doi:10.1002/14651858.CD007813.Google Scholar
Castells, X, Ramos-Quiroga, JA, Rigau, D, Bosch, R, Nogueira, M, Vidal, X, Casas, M (2011b). Efficacy of methylphenidate for adults with attention-deficit hyperactivity disorder: a meta-regression analysis. CNS Drugs 2, 157169.CrossRefGoogle Scholar
Charach, A, Yeung, E, Climans, T, Lillie, E (2011). Childhood attention deficit/hyperactivity disorder and future substance use disorders: comparative meta-analyses. Journal of the American Academy of Child & Adolescent Psychiatry 50, 921.CrossRefGoogle ScholarPubMed
Chronis, AM, Lahey, BB, Pelham, WE, Kipp, HL, Baumann, BL, Lee, SS (2003). Psychopathology and substance abuse in parents of young children with attention-deficit/hyperactivity disorder. Journal of the American Academy of Child & Adolescent Psychiatry 42, 14241432.CrossRefGoogle ScholarPubMed
Clarke, C, Fitzpatrick, C (2005). Psychiatric problems in children exposed to opiates in utero. Irish Journal of Psychological Medicine 22, 121123.CrossRefGoogle ScholarPubMed
Daly, A, Walsh, D (2010). Activities of Irish psychiatric units and hospitals 2009: main findings. HRB Statistics Series 9. Health Research Board: Dublin.Google Scholar
Davids, E, Gastpar, M (2003). Attention-deficit/hyperactivity disorder and substance abuse. Psychiatrische Praxis 30, 182186.Google ScholarPubMed
Edokpolo, O, Nkire, N, Smyth, BP (2010). Irish Adolescents with ADHD and comorbid substance use disorder. Irish Journal of Psychological Medicine 27, 148151.CrossRefGoogle ScholarPubMed
Faraone, SV, Sergeant, J, Gillberg, C, Biederman, J (2003). The worldwide prevalence of ADHD: is it an American condition? World Psychiatry 2, 104113.Google ScholarPubMed
Fayyad, J, De Graaf, R, Kessler, R, Alonso, J, Angermeyer, M, Demyttenaere, K, De Girolamo, G, Haro, JM, Karam, EG, Lara, C, Lepine, JP, Ormel, J, Posada-Villa, J, Zaslavsky, AM, Jin, R (2007). Cross-national prevalence and correlates of adult attention-deficit hyperactivity disorder. British Journal of Psychiatry 190, 402409.CrossRefGoogle ScholarPubMed
Fitzgerald, M (1998). Adult attention deficit hyperactivity disorder. Irish Journal of Psychological Medicine 15, 8283.CrossRefGoogle Scholar
Fitzgerald, M (2001). Psychopharmacological treatment of adolescent and adult attention deficit hyperactivity disorder. Irish Journal of Psychological Medicine 18, 9398.CrossRefGoogle ScholarPubMed
Fitzgerald, M (2005). Attention Deficit Hyper Activity Disorder in adulthood. Irish Journal of Psychological Medicine 22, 134.Google Scholar
Goossensen, MA, van de Glind, G, Carpentier, PJ, Wijsen, RMA, van Duin, D, Kooij, S (2006). An intervention program for ADHD in patients with substance use disorders: preliminary results of a field trial. Journal of Substance Abuse Treatment 30, 253259.CrossRefGoogle ScholarPubMed
Hinshaw, SP, Owens, EB, Sami, N, Fargeon, S (2006). Prospective follow-up of girls with attention-deficit/hyperactivity disorder into adolescence: evidence for continuing cross-domain impairment. Journal of Consulting and Clinical Psychology 74, 489499.CrossRefGoogle ScholarPubMed
James, PD, Smyth, BP, Apantaku-Olajide, T (2013). Substance use and psychiatric disorders in Irish adolescents: a cross sectional study of patients attending substance abuse treatment service. Mental Health and Substance Use 6 (2), 124132.CrossRefGoogle Scholar
Kalbag, AS, Levin, FR (2005). Adult ADHD and substance abuse: diagnostic and treatment issues. Substance Use and Misuse 40, 19551981, 2043–2048.CrossRefGoogle ScholarPubMed
Kessler, RC, Adler, L, Barkley, R, Biederman, J, Conners, CK, Demler, O, etal. (2006). The prevalence and correlates of adult ADHD in the United States: results from the national comorbidity survey replication. American Journal of Psychiatry 163, 716723.CrossRefGoogle ScholarPubMed
Kessler, RC, Adler, LA, Barkley, R, Biederman, J, Conners, CK, Faraone, SV, Greenhill, LL, Howes, MJ, Secnik, K, Spencer, T, Ustun, TB, Walters, EE, Zaslavsky, AM (2005). Patterns and predictors of attention deficit/hyperactivity disorder persistence into adulthood: results from the national comorbidity survey replication. Biological Psychiatry 57, 14421451.CrossRefGoogle ScholarPubMed
Kirley, A, Fitzgerald, M (2002). Adult attention deficit hyperactivity disorder: a controversial diagnosis. Irish Journal of Psychological Medicine 19, 8691.CrossRefGoogle ScholarPubMed
Konstenius, M, Jayaram-Lindström, N, Beck, O, Franck, J (2010). Sustained release methylphenidate for the treatment of ADHD in amphetamine abusers: a pilot study. Drug and Alcohol Dependence 108, 130133.CrossRefGoogle ScholarPubMed
Lee, SS, Humphreys, KL, Flory, K, Liu, R, Glass, K (2011). Prospective association of childhood attention-deficit/hyperactivity disorder (ADHD) and substance use and abuse/dependence: a meta-analytic review. Clinical Psychology Review 31, 328341.CrossRefGoogle ScholarPubMed
Lee, SS, Lahey, BB, Owens, EB, Hinshaw, SP (2008). Few preschool boys and girls with ADHD are well-adjusted during adolescence. Journal of Abnormal Child Psychology 36, 373383.CrossRefGoogle ScholarPubMed
Levin, FR, Evans, SM, Brooks, DJ, Garawi, F (2007). Treatment of cocaine dependent treatment seekers with adult ADHD: double-blind comparison of methylphenidate and placebo. Drug and Alcohol Dependence 87, 2029.CrossRefGoogle ScholarPubMed
Levin, FR, Evans, SM, Brooks, DJ, Kalbag, AS, Garawi, F, Nunes, EV (2006). Treatment of methadone-maintained patients with adult ADHD: double-blind comparison of methylphenidate, bupropion and placebo. Drug and Alcohol Dependence 81, 137148.CrossRefGoogle ScholarPubMed
Lynch, F, Mills, C, Daly, I, Fitzpatrick, C (2006). Challenging times: prevalence of psychiatric disorders and suicidal behaviours in Irish adolescents. Journal of Adolescence 29, 555573.CrossRefGoogle ScholarPubMed
Lynskey, MT, Hall, W (2001). Attention deficit hyperactivity disorder and substance use disorders: is there a causal link? Addiction 96, 815822.CrossRefGoogle ScholarPubMed
Matsumoto, T, Kamijo, A, Yamaguchi, A, Iseki, E, Hirayasu, Y (2005). Childhood histories of attention-deficit hyperactivity disorders in Japanese methamphetamine and inhalant abusers: preliminary report. Psychiatry and Clinical Neurosciences 59, 102105.CrossRefGoogle ScholarPubMed
Matthies, S, Philipsen, A, Svaldi, J (2012). Risky decision making in adults with ADHD. Journal of Behavior Therapy and Experimental Psychiatry 43, 938946.CrossRefGoogle ScholarPubMed
Meltzer, H, Gatward, R, Goodman, R, Ford, T (2000). Mental health of children and adolescents in Great Britain: office for national statistics. Stationery Office: London.CrossRefGoogle Scholar
Molina, BSG, Marshal, MP, Pelham, WE Jr, Wirth, RJ (2005). Coping skills and parent support mediate the association between childhood attention-deficit/hyperactivity disorder and adolescent cigarette use. Journal of Pediatric Psychology 30, 345357.CrossRefGoogle ScholarPubMed
Owens, EB, Hinshaw, SP, Lee, SS, Lahey, BB (2009). Few girls with childhood attention-deficit/hyperactivity disorder show positive adjustment during adolescence. Journal of Clinical Child & Adolescent Psychology 38, 132143.CrossRefGoogle ScholarPubMed
Polanczyk, G, Rohde, LA (2007). Epidemiology of attention-deficit/hyperactivity disorder across the lifespan. Current Opinions in Psychiatry 20, 386392.CrossRefGoogle ScholarPubMed
Riggs, PD, Levin, F, Green, AI, Vocci, F (2008). Comorbid psychiatric and substance abuse disorders: recent treatment research. Substance Abuse 29, 5163.CrossRefGoogle ScholarPubMed
Scahill, L, Schwab-Stone, M (2000). Epidemiology of ADHD in school-age children. Child and Adolescent Psychiatric Clinics of North America 9, 541555.CrossRefGoogle ScholarPubMed
Sullivan, MA, Rudnik-Levin, F (2001). Attention deficit/hyperactivity disorder and substance abuse. Diagnostic and therapeutic considerations. Annals of the New York Academy of Sciences 931, 251270.CrossRefGoogle ScholarPubMed
Syed, H, Masaud, TM, Nkire, N, Iro, C, Garland, MR (2010). Estimating the prevalence of adult ADHD in the psychiatric clinic: a cross-sectional study using the adult ADHD self-report scale (ASRS). Irish Journal of Psychological Medicine 27, 195197.CrossRefGoogle Scholar
Thurstone, C, Riggs, PD, Salomonsen-Sautel, S, Mikulich-Gilbertson, CK (2010). Randomized, controlled trial of atomoxetine for attention-deficit/hyperactivity disorder in adolescents with substance use disorder. Journal of the American Academy of Child & Adolescent Psychiatry 49, 573582.Google ScholarPubMed
Van den Brink, W (2012). Screening for Adult ADHD in SUD Patients Reliability and Validity of the ASRS-v1 (Preliminary Results). ICASA Satellite Symposium Bordeaux, September 2012.Google Scholar
van Emmerik-van Oortmerssen, K, van de Glind, G, van den Brink, W, Smit, F (2012). Prevalence of attention-deficit hyperactivity disorder in substance use disorder patients: a meta-analysis and meta-regression analysis. Drug and Alcohol Dependence 122, 1119.CrossRefGoogle ScholarPubMed
Wender, PH, Wolf, LE, Wasserstein, J (2001). Adults with ADHD. An overview. Annals of the New York Academy of Sciences 931, 116.CrossRefGoogle ScholarPubMed
Wilens, TE (2004). Attention-deficit/hyperactivity disorder and the substance use disorders: the nature of the relationship, subtypes at risk, and treatment issues. Psychiatric Clinics of North America 27, 283301.CrossRefGoogle ScholarPubMed
Wilens, TE, Fusillo, S (2007). When ADHD and substance use disorders intersect: relationship and treatment implications. Current Psychiatry Reports 9, 408414.CrossRefGoogle ScholarPubMed
Wilens, TE, Upadhyaya, HP (2007). Impact of substance use disorder on ADHD and its treatment. Journal of Clinical Psychiatry 68, e20.CrossRefGoogle ScholarPubMed
Wilens, T, Martelon, MK, Joshi, G, Bateman, C, Fried, R, Petty, C, Biederman, J (2011). Does ADHD predict substance-use disorders? A 10-year follow-up study of young adults with ADHD. Journal of the American Academy of Child & Adolescent Psychiatry 50, 543553.CrossRefGoogle ScholarPubMed
Figure 0

Table 1 Demographic participant details