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Expression patterns of histone deacetylases in bovine oocytes and early embryos, and the effect of their inhibition on embryo development

Published online by Cambridge University Press:  14 May 2001

Hanna Segev ,
Erdogan Memili  and
Neal L. First
Hanna Segev
Affiliation:
Endocrinology and Reproductive Physiology Program, Department of Animal Sciences, University of Wisconsin-Madison, WI 53706, USA
Erdogan Memili
Affiliation:
Endocrinology and Reproductive Physiology Program, Department of Animal Sciences, University of Wisconsin-Madison, WI 53706, USA
Neal L. First
Affiliation:
Endocrinology and Reproductive Physiology Program, Department of Animal Sciences, University of Wisconsin-Madison, WI 53706, USA
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Abstract

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Gene expression at the onset of bovine embryogenesis is developmentally regulated and histone deacetylases (HDACs) have been shown to play a key role in the control of gene expression during this period of development in other species. We determined expression pattern(s) of powerful repressors, namely histone deacetylase-1, -2 and -3, that may in part regulate gene expression during bovine oogenesis and early embryogenesis at the mRNA and protein levels. Detected fragments of the hdac genes were sequenced and comparison of the sequences showed very high homologies between DNA and amino acid sequences of bovine HDACs and those of human and mouse. RPD3, a yeast global regulator of transcription, was also detected in bovine oocytes and embryos. Results suggest that HDACs may be operative in regulation of zygotic/embryonic gene expression in cattle.

Keywords

BovineDeacetylaseEmbryoHistoneOocyteTranscription
Type
Research Article
Information
Zygote , Volume 9 , Issue 2 , May 2001 , pp. 123 - 133
Copyright
2001 Cambridge University Press