The St. Thomas' UK Adult Twin Registry

Tim D. Spector; Alex J. MacGregor

doi:10.1375/twin.5.5.440

Abstract

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The Registry consists of nearly 10,000 monozygous and dizygous adult caucasian twins aged 18–80 from all over the UK and was started in 1993. This is a volunteer sample recruited by successive media campaigns without selecting for particular diseases or traits. All twins receive a series of disease questionnaires. In addition over half the twins have been assessed in detail clinically for several hundred phenotypes related to common diseases or intermediate traits. The focus has been primarily on cardiovascular, metabolic, musculoskeletal, dermatological, and opthalmological diseases. Over 3000 DZ twins have had a genome wide scan performed as well as many candidate genes allowing both linkage and association studies. The registry has led to many successful innovative research projects, particularly in common diseases previously thought to be predominantly environmental and helped positionally clone some novel genes for common diseases.

Crossref Citations

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Garner, Chad Silver, Nicholas Best, Steve Menzel, Stephan Martin, Charlotte Spector, Tim D. and Thein, Swee Lay 2004. Quantitative trait locus on chromosome 8q influences the switch from fetal to adult hemoglobin. Blood, Vol. 104, Issue. 7, p. 2184.

Hammond, Christopher J. Andrew, Toby Tat Mak, Ying and Spector, Tim D. 2004. A Susceptibility Locus for Myopia in the Normal Population Is Linked to the PAX6 Gene Region on Chromosome 11: A Genomewide Scan of Dizygotic Twins. The American Journal of Human Genetics, Vol. 75, Issue. 2, p. 294.

de Lange, Marlies Spector, Tim D. and Andrew, Toby 2004. Genome-Wide Scan for Blood Pressure Suggests Linkage to Chromosome 11, and Replication of Loci on 16, 17, and 22. Hypertension, Vol. 44, Issue. 6, p. 872.

Williams, Frances MK Cherkas, Lynn F Spector, Tim D and MacGregor, Alex J 2004. A common genetic factor underlies hypertension and other cardiovascular disorders. BMC Cardiovascular Disorders, Vol. 4, Issue. 1,

Dunn, Emma J. Ariëns, Robert A. de Lange, Marlies Snieder, Harold Turney, John H. Spector, Timothy D. and Grant, Peter J. 2004. Genetics of fibrin clot structure: a twin study. Blood, Vol. 103, Issue. 5, p. 1735.

Dong, Yanbin Zhu, Haidong Wang, Xiaoling Dalageorgou, Chrysoula Carter, Nick Spector, Tim D and Snieder, Harold 2004. Obesity reveals an association between blood pressure and the G-protein β3-subunit gene. Pharmacogenetics, Vol. 14, Issue. 7, p. 419.

Mohammed, Imtiyaz Cherkas, Lynn F. Riley, Stuart A. Spector, Tim D. and Trudgill, Nigel J. 2005. Genetic Influences in Irritable Bowel Syndrome: A Twin Study. The American Journal of Gastroenterology, Vol. 100, Issue. 6, p. 1340.

Chen, Yuanneng Snieder, Harold Wang, Xiaoling Kaviya, Bhavini McCaffrey, Clare Spector, Tim D Carter, Nicholas D and O'Dell, Sandra D 2005. Proopiomelanocortin gene variants are associated with serum leptin and body fat in a normal female population. European Journal of Human Genetics, Vol. 13, Issue. 6, p. 772.

Williams, F M K Cherkas, L F Spector, T D and MacGregor, A J 2005. The effect of moderate alcohol consumption on bone mineral density: a study of female twins. Annals of the Rheumatic Diseases, Vol. 64, Issue. 2, p. 309.

Dunn, Kate M Cherkas, Lynn F and Spector, Tim D 2005. Genetic influences on variation in female orgasmic function: a twin study. Biology Letters, Vol. 1, Issue. 3, p. 260.

Falchi, Mario Andrew, Toby Snieder, Harold Swaminathan, Ramasamyiyer Surdulescu, Gabriela L. and Spector, Tim D. 2005. Identification of QTLs for serum lipid levels in a female sib-pair cohort: a novel application to improve the power of two-locus linkage analysis. Human Molecular Genetics, Vol. 14, Issue. 20, p. 2971.

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Jiang, Jie Best, Steve Menzel, Stephan Silver, Nicholas Lai, Mei I. Surdulescu, Gabriela L. Spector, Tim D. and Thein, Swee Lay 2006. cMYB is involved in the regulation of fetal hemoglobin production in adults. Blood, Vol. 108, Issue. 3, p. 1077.

Jamshidi, Y. Snieder, H. Wang, X. Pavitt, M. J. Spector, T. D. Carter, N. D. and O’Dell, S. D. 2006. Phosphatidylinositol 3-kinase p85α regulatory subunit gene PIK3R1 haplotype is associated with body fat and serum leptin in a female twin population. Diabetologia, Vol. 49, Issue. 11, p. 2659.

Jamshidi, Y. Snieder, H. Wang, X. Spector, T. D. Carter, N. D. and O’Dell, S. D. 2006. Common polymorphisms in SOCS3 are not associated with body weight, insulin sensitivity or lipid profile in normal female twins. Diabetologia, Vol. 49, Issue. 2, p. 306.

Singer, Jamie J. MacGregor, Alex J. Cherkas, Lynn F. and Spector, Tim D. 2006. Genetic influences on cognitive function using The Cambridge Neuropsychological Test Automated Battery. Intelligence, Vol. 34, Issue. 5, p. 421.

Zhai, G Aviv, A Hunter, D J Hart, D J Gardner, J P Kimura, M Lu, X Valdes, A M and Spector, T D 2006. Reduction of leucocyte telomere length in radiographic hand osteoarthritis: a population-based study. Annals of the Rheumatic Diseases, Vol. 65, Issue. 11, p. 1444.

de Lange, Marlies Andrew, Toby Snieder, Harold Ge, Dongliang Futers, T. Simon Standeven, Kristina Spector, Tim D. Grant, Peter J. and Ariëns, Robert A.S. 2006. Joint Linkage and Association of Six Single-Nucleotide Polymorphisms in the Factor XIII-A Subunit Gene Point to V34L As the Main Functional Locus. Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 26, Issue. 8, p. 1914.

Harding, Brian Curley, Alan J. Hannan, Fadil M. Christie, Paul T. Bowl, Michael R. Turner, Jeremy J. O. Barber, Mathew Gillham‐Nasenya, Irina Hampson, Geeta Spector, Tim D. and Thakker, Rajesh V. 2006. Functional characterization of calcium sensing receptor polymorphisms and absence of association with indices of calcium homeostasis and bone mineral density. Clinical Endocrinology, Vol. 65, Issue. 5, p. 598.

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