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Normal Asymmetry of the Planum Temporale in Patients with Schizophrenia

Three-Dimensional Cortical Morphometry with MRI

Published online by Cambridge University Press:  02 January 2018

Jennifer J. Kulynych ,
Katalin Vladar ,
Bryan D. Fantie ,
Douglas W. Jones  and
Daniel R. Weinberger
Jennifer J. Kulynych
Affiliation:
Human Neuropsychology Laboratory, The American University, Washington, DC 20016-8062, USA NIMH Neuroscience Center at St Elizabeth's, Washington, DC
Katalin Vladar
Affiliation:
Human Neuropsychology Laboratory, The American University, Washington, DC 20016-8062, USA NIMH Neuroscience Center at St Elizabeth's, Washington, DC
Bryan D. Fantie
Affiliation:
Clinical Brain Disorders Branch, NIMH Neuroscience Center at St Elizabeth's
Douglas W. Jones
Affiliation:
Clinical Brain Disorders Branch, NIMH Neuroscience Center at St Elizabeth's
Daniel R. Weinberger*
Affiliation:
Clinical Brain Disorders Branch, NIMH Neuroscience Center at St Elizabeth's
*
Dr D. R. Weinberger, Clinical Brain Disorder Branch, NIMH Neuroscience Center at St Elizabeth's, Intramural Research Program, National Institute of Mental Health, Washington, DC 20032
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Extract

Background

Abnormal cerebral anatomical lateralisation has been reported in schizophrenia and may implicate anomalous neurodevelopment in the aetiology of this disease. A popular recent hypothesis has predicted that such disturbances in normal lateralisation should be especially apparent in the morphology of the temporal lobes.

Method

A temporal cortical region lying in the plane of the Sylvian fissure – known as the planum temporale – exhibits pronounced leftward asymmetry in normal right-handed males. We compared lateralisation of the planum temporale in schizophrenic and control males using MRI surface-rendering morphometry of the supratemporal cortex.

Results

Contrary to the lateralisation hypothesis, normal patterns of leftward planum asymmetry were detected in both the schizophrenic and control groups. Schizophrenics and controls also exhibited a predicted symmetry in the bilateral areas of Heschl's gyrus, a supratemporal cortical structure immediately anterior to the planum.

Conclusion

These data do not support the notion that neurodevelopmental mechanisms of cerebral asymmetry are abnormal in schizophrenia.

Type
Papers
Information
The British Journal of Psychiatry , Volume 166 , Issue 6 , June 1995 , pp. 742 - 749
Copyright
Copyright © Royal College of Psychiatrists, 1995 

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