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Schizophrenia and Marfan Syndrome

Published online by Cambridge University Press:  02 January 2018

Pinkhas Sirota ,
Moshe Frydman  and
Lea Sirota
Pinkhas Sirota*
Affiliation:
Yehuda Arbarbanel Mental Health Center Bat Yam, Israel Sackler School of Medicine, Tel Aviv University, Israel
Moshe Frydman
Affiliation:
Genetics Clinic, Department of Pediatrics, Golda Medical Center, Hasharon Hospital, Petah Tiqwa and Sackler School of Medicine, Tel Aviv University, Israel
Lea Sirota
Affiliation:
Neonatology Department Golda Medical Center, Hasharon Hospital, Petah Tiqwa and Sackler School of Medicine, Tel Aviv University, Israel
*
∗Yehuda Abarbanel Mental Health Center, Bat Yam, Israel
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Five index patients and three of their first-degree relatives were affected both by schizophrenia and Marfan syndrome. Since the association appears statistically significant, the possibility of linkage disequilibrium between adjacent genes or a cytogenetic abnormality causing both disorders is suggested. These hypotheses are testable and hold promise in attempting to map the ‘schizophrenia susceptibility gene’ by the candidate-gene approach.

Type
Brief Reports
Information
The British Journal of Psychiatry , Volume 157 , Issue 3 , September 1990 , pp. 433 - 436
Copyright
Copyright © Royal College of Psychiatrists, 1990 

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