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The place of school-based strategies for universal, selective and indicated prevention for depression

Published online by Cambridge University Press:  13 January 2025

A response to the following question: What is the place of universal, selective, and indicated prevention strategies for depression and other mood disorders?

Louise Birrell*
Affiliation:
The Matilda Centre for Research in Mental Health and Substance Use, The University of Sydney, Sydney, NSW, Australia
Lucinda Grummitt
Affiliation:
The Matilda Centre for Research in Mental Health and Substance Use, The University of Sydney, Sydney, NSW, Australia
Helen Christensen
Affiliation:
Black Dog Institute & Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia
Maree Teesson
Affiliation:
The Matilda Centre for Research in Mental Health and Substance Use, The University of Sydney, Sydney, NSW, Australia
*
Corresponding author: Louise Birrell; Email: louise.birrell@sydney.edu.au
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Abstract

In response to the question, ‘What is the place of universal, selective and indicated prevention strategies for depression and other mood disorders?’ posed by Hickie et al. (2024), we examine the role of school-based strategies for universal and targeted (including selective and indicated) prevention of depression. Schools represent a unique opportunity for systematic evidence-based depression prevention, targeting key developmental risk periods before peak depression onset. However, the realisation of this potential has been challenging particularly for universal approaches. We summarise the evidence for each of these tiers of prevention, including recent large-scale trials of universal prevention in high-income countries. Targeted approaches show more consistent preventive effects on depression however hold significant implementation challenges in the school context. We provide recommendations about the next steps for the field including a continuum of support across all levels of prevention outlined above and broadening current strategies to focus on the school contexts and structural factors in which prevention programs are delivered, as well as teacher mental health.

Type
Impact Paper
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
Copyright
© The Author(s) 2025. Published by Cambridge University Press

Introduction

Depression strikes early, with a substantial number of cases (13%) emerging before age 18 and median age onset of 30 years (Solmi et al., Reference Solmi, Radua, Olivola, Croce, Soardo, Salazar de Pablo, Il Shin, Kirkbride, Jones, Kim, Kim, Carvalho, Seeman, Correll and Fusar-Poli2022). This means depression impacts people on the verge of adulthood, with significant follow-on disruption to employment, education, relationships and future life trajectory. Rates of depression are increasing across the globe, with the highest rates of increase observed among youth (McGorry et al., Reference McGorry, Mei, Dalal, Alvarez-Jimenez, Blakemore, Browne, Dooley, Hickie, Jones, McDaid, Mihalopoulos, Wood, El Azzouzi, Fazio, Gow, Hanjabam, Hayes, Morris, Pang and Killackey2024; Twenge et al., Reference Twenge, Cooper, Joiner, Duffy and Binau2019). Alongside timely access to effective treatment, prevention of depression is critically needed.

Education settings, especially schools, offer the potential to provide systematic evidence-based prevention of depression to the vast majority of the youth population at a key developmental time, before the peak onset of depression (Solmi et al., Reference Solmi, Radua, Olivola, Croce, Soardo, Salazar de Pablo, Il Shin, Kirkbride, Jones, Kim, Kim, Carvalho, Seeman, Correll and Fusar-Poli2022). They also afford the opportunity to deliver developmentally appropriate strategies, targeted at different ages and year levels and can utilise any of the three tiers of prevention: universal, selective or indicated. The significant challenge is how to realise this potential. In a field where the evidence base is growing exponentially, delivering the most effective prevention at the right time in an education setting is critical but not simple. Importantly, some of the largest universal prevention trials have failed to demonstrate effects on depression outcomes (Kuyken et al., Reference Kuyken, Ball, Crane, Ganguli, Jones, Montero-Marin, Nuthall, Raja, Taylor, Tudor, Viner, Allwood, Aukland, Dunning, Casey, Dalrymple, De Wilde, Farley, Harper and Williams2022; Teesson et al., Reference Teesson, Birrell, Slade, Mewton, Olsen, Hides, McBride, Chatterton, Allsop, Furneaux-Bate, Bryant, Ellem, Baker, Healy, Debenham, Boyle, Mather, Mihalopoulos, Chapman and Newton2024).

Here, we summarise the existing evidence base for the different tiers of school-based strategies to prevent depression (including programs with impacts on more precursive symptomology such as emotional symptoms and more recent programs with broader, novel targets). We conclude with recommendations for schools, researchers and policymakers. We focus our summary on depression outcomes, noting that the prevention approaches described below can also impact other related factors including, but not limited to, anxiety, substance misuse, self-harm and overall health literacy.

Universal school-based prevention

Universal prevention approaches are a key opportunity for schools with several strengths. They enable broad reach to the whole cohort of students, thereby promoting equitable access to prevention. This is further amplified with the use of new technologies, such as digital programs and adjuncts (e.g. mobile phone apps), text-to-speech and translation technologies to deliver prevention messaging to students from a range of backgrounds and literacy levels. Universal programs can improve mental health literacy (knowledge) among all students (Teesson et al., Reference Teesson, Newton, Slade, Chapman, Birrell, Mewton, Mather, Hides, McBride, Allsop and Andrews2020) and have the potential to normalise seeking support for mental health difficulties, including depression. Universal approaches also avoid the potential stigmatising effect of identifying groups or individuals at greater risk of depression, a potential disadvantage of targeted approaches. Moreover, universal programs are often preferred by schools themselves, as they are generally easier to implement and cost-effective and align with school priorities to address mental health and wellbeing in all students (Beames et al., Reference Beames, Johnston, O’Dea, Torok, Christensen, Boydell and Werner-Seidler2021). Finally, due to their broad reach and cumulative impact, universal programs need only to demonstrate modest effects to have a substantial impact in reducing the burden of depression at a population level (Matthay et al., Reference Matthay, Hagan, Gottlieb, Tan, Vlahov, Adler and Glymour2021).

Despite the promise of universal prevention of depression through schools, the existing evidence base is mixed. Systematic reviews have reported the overall benefits of universal school-based programs for depression, noting effect sizes are small and short term (Hetrick et al., Reference Hetrick, Cox, Witt, Bir and Merry2016; Werner-Seidler et al., Reference Werner-Seidler, Spanos, Calear, Perry, Torok, O’Dea, Christensen and Newby2021). However, due to problems with the methodological quality of some studies included in these reviews, it has been argued that it is difficult to make the conclusion that universal approaches for depression prevention are effective or not (Cuijpers, Reference Cuijpers2022). Since this review, three recent large trials in the UK and Australia, with a rigorous methodology, have found null effects of universal interventions on depression outcomes. The UK My Resilience In Adolescence (MYRIAD) trial (n = 8,376) (Kuyken et al., Reference Kuyken, Ball, Crane, Ganguli, Jones, Montero-Marin, Nuthall, Raja, Taylor, Tudor, Viner, Allwood, Aukland, Dunning, Casey, Dalrymple, De Wilde, Farley, Harper and Williams2022) utilised teacher-led mindfulness exercises. In contrast, the Australian trials included the Climate Schools Combined (CSC) trial (n = 6,386) (Teesson et al., Reference Teesson, Newton, Slade, Chapman, Birrell, Mewton, Mather, Hides, McBride, Allsop and Andrews2020), which employed a digital program based on cognitive behavioural therapy (CBT) principles targeting anxiety, depression and substance use, and the Health4Life study (n = 6,639) (Smout et al., Reference Smout, Champion, O’Dean, Teesson, Gardner and Newton2024), which targeted key lifestyle risk factors (e.g. diet, sleep, physical activity) known to interact with mental health. All three of these large, well-powered trials found no significant improvement in depressive outcomes at the primary trial timepoints for students who received the interventions compared to those in control conditions. However, the CSC trial (Teesson et al., Reference Teesson, Newton, Slade, Chapman, Birrell, Mewton, Mather, Hides, McBride, Allsop and Andrews2020) demonstrated significant increases in mental health literacy, including depression knowledge, and the indirect Health4Life study (Smout et al., Reference Smout, Champion, O’Dean, Teesson, Gardner and Newton2024) observed short-term improvements in depression symptoms (not maintained at later follow-up). The reasons these trial results were not consistent with previous studies are not clear, but the fact they were larger than most earlier trials raises questions about the ability to sustain positive preventive effects when prevention programs are taken to scale. It is also of note these trials occurred in high-income countries in which mental health education in schools is relatively commonplace; therefore, it is likely the control group also received some form of mental health education, making effects harder to demonstrate. Only a small number of large-scale school-based trials have been undertaken in low- and middle-income countries (LMIC). A 2019 review of school-based prevention for depression and anxiety found that of 76 studies, only 5 were conducted in LMIC (Caldwell et al., Reference Caldwell, Davies, Hetrick, Palmer, Caro, López-López, Gunnell, Kidger, Thomas, French, Stockings, Campbell and Welton2019). Another review of universal prevention in LMIC found the evidence base was weak, largely due to the small study size and methodological weaknesses (Bradshaw et al., Reference Bradshaw, Gericke, Coetzee, Stallard, Human and Loades2021). Given global disparities in access to care and education, more research in LMIC is urgently needed. In summary, the current landscape of existing universal prevention shows limited evidence of lasting long-term positive effects for depression prevention when interventions are delivered at scale.

An inherent difficulty with universal prevention is varying levels of risk and pre-existing symptoms of depression within the whole population of students. Universal programs must strive to be engaging for all, or at least, most students. Yet most students do not show elevated symptoms or risk of depression. This has resulted in universal interventions typically being low-intensity interventions, aiming to promote knowledge of depression, positive coping strategies and help-seeking behaviours. For students already exhibiting elevated symptoms of depression, it has been suggested that universal programs may serve to raise awareness or discomfort around these feelings, without providing the skills or resources required to manage these feelings effectively (Montero-Marin et al., Reference Montero-Marin, Allwood, Ball, Crane, De Wilde, Hinze, Jones, Lord, Nuthall, Raja, Taylor, Tudor, Blakemore, Byford, Dalgleish, Ford, Greenberg, Ukoumunne, Williams and Kuyken2022). However, it is noted that universal programs that have actively taught psychological skills (such as cognitive behavioural techniques) have been shown to be effective, at least in smaller trials in the short term (Werner-Seidler et al., Reference Werner-Seidler, Spanos, Calear, Perry, Torok, O’Dea, Christensen and Newby2021). Future directions for universal prevention of depression in the school context might include a better understanding of how depression prevention programs are implemented in the school setting and the role of school climate (including existing mental health supports and a sense of belonging) as well as other mediating factors when these programs are adopted by schools.

It is also important to clarify the objective of prevention trials, which is inherently different from that of treatment. A treatment program is deemed effective when symptoms or cases reduce pre- to post-program delivery (and compared to those in a control condition, who would be expected to worsen or remain stable without treatment). In contrast, prevention research is looking to establish a lower rate or lack of increase in symptoms in the intervention group, compared to a control group (who also worsen) (Nehmy & Wade, Reference Nehmy and Wade2014). Genuine prevention trials, particularly universal trials delivered to students with mostly low overall risk/symptoms, aim to flatten the overall curve of increase, rather than reduce symptoms as their key goal. It has further been suggested that universal prevention may be better placed to target broad aetiological mechanisms that are transdiagnostic as a way to impact depression outcomes (among others) (Nehmy & Wade, Reference Nehmy and Wade2014). Some of these targets may include individual factors such as low effortful control and high negative affect, as well as broader environmental factors such as adverse life events and familial mental illness (Lynch et al., Reference Lynch, Sunderland, Newton and Chapman2021), noting the latter factors may not be as closely linked to the current remit of schools.

Targeted prevention

Targeted prevention strategies are those specifically targeted towards certain individuals and include both selective and indicated prevention. Selective prevention targets groups or individuals considered at higher risk of disorder based on known risk factors, while indicated prevention is directed at those with subthreshold symptoms (but not yet disorder). Selective and indicated school-based programs typically produce larger effect sizes compared to universal programs (Conrod, Reference Conrod2016; Hetrick et al., Reference Hetrick, Cox, Witt, Bir and Merry2016; Werner-Seidler et al., Reference Werner-Seidler, Spanos, Calear, Perry, Torok, O’Dea, Christensen and Newby2021). These strategies can be cost-effective, by delivering prevention resources to where they’re most needed and producing larger benefits for the time and money invested. Additionally, by targeting prevention based on the presence of risk factors, programs and messaging can be tailored to meet the specific needs of the at-risk population.

Despite these benefits, there are several disadvantages to targeted prevention. Unlike universal approaches, targeted prevention necessitates the identification of individuals or groups who are at greater risk of developing a disorder or who are already experiencing symptoms. For selective approaches, this requires research to not only identify factors that affect mean differences in the risk of disorder across groups but also further establish the predictive value of that risk factor at the individual level (Arango et al., Reference Arango, Díaz-Caneja, McGorry, Rapoport, Sommer, Vorstman, McDaid, Marín, Serrano-Drozdowskyj, Freedman and Carpenter2018). As an example, while decades of research have shown that adverse childhood experiences (ACEs) are a risk factor for depression, not all children who experience ACEs develop a depressive disorder, and exposure alone is a poor predictor of which children will develop problems (Baldwin et al., Reference Baldwin, Caspi, Meehan, Ambler, Arseneault, Fisher, Harrington, Matthews, Odgers, Poulton, Ramrakha, Moffitt and Danese2021; Meehan et al., Reference Meehan, Baldwin, Lewis, MacLeod and Danese2022). Thus, despite knowledge of mean differences in the risk of depression across groups based on ACE exposure, we are a little closer to being able to accurately predict individual psychopathology from this risk factor (Baldwin et al., Reference Baldwin, Caspi, Meehan, Ambler, Arseneault, Fisher, Harrington, Matthews, Odgers, Poulton, Ramrakha, Moffitt and Danese2021; Meehan et al., Reference Meehan, Baldwin, Lewis, MacLeod and Danese2022). In addition, by identifying those at greater risk or already experiencing symptoms of depression, targeted prevention has the potential to stigmatise or detrimentally label groups or individuals if implemented poorly. Finally, implementation of targeted prevention in schools is more challenging compared to universal approaches, with generally a greater cost per person required for screening, facilitator training and difficulties with scheduling when only some students need to attend intervention sessions. It can also be more difficult to obtain parental consent, which is often mandated as opt-in for selective/targeted approaches versus opt-out for universal prevention. This extra barrier to participation in targeted programs means this approach can be more difficult to implement, especially when parental support is low, meaning students may miss out even if they wish to participate.

Despite these concerns, the evidence base for targeted prevention in schools shows benefits for depression prevention. Meta-analyses and reviews show more consistent and larger effect sizes compared to universal approaches (Conrod, Reference Conrod2016; Hetrick et al., Reference Hetrick, Cox, Witt, Bir and Merry2016; Werner-Seidler et al., Reference Werner-Seidler, Spanos, Calear, Perry, Torok, O’Dea, Christensen and Newby2021). This is to be expected, given these programs target groups at higher risk who are also more likely to report higher symptoms, with more room to move. One selective program, Preventure, targets personality risk factors for substance use and co-occurring emotional (including negative affect) and behavioural problems. The program is delivered across two sessions with an external clinical psychologist running sessions in school, tailored to four personality profiles and has demonstrated reductions in adolescent depressive symptoms across three randomised controlled trials in the UK and Australia (Castellanos & Conrod, Reference Castellanos and Conrod2006; Newton et al., Reference Newton, Stapinski, Teesson, Slade, Champion, Barrett, Birrell, Kelly, Mather and Conrod2020; Maeve O’Leary-Barrett et al., Reference O’Leary-Barrett, Topper, Al-Khudhairy, Pihl, Castellanos-Ryan, Mackie and Conrod2013). Another indicated program, the High School Transition Program, targets students with elevated depressive symptoms at the transition point to high school. It is a brief, skill-based program shown to reduce depression in those with elevated depressive symptoms through enhancing student’s abilities to manage environmental stressors such as school transition (Blossom et al., Reference Blossom, Adrian, Stoep and McCauley2020).

Whole-of-school approaches

As summarised in Table 1, there are advantages and disadvantages to both universal and targeted prevention of depression. Rather than picking one strategy over another, ideally, schools would provide a continuum of support across the different levels above, as it is unlikely a single program or strategy will be able to prevent depression for every student. For some students, whole-of-school approaches to promote wellbeing and universal programs that equip students with basic literacy and skills may be enough. For others, greater intervention and proactive selective and targeted prevention are needed. It is also important to note that to date, nearly all school-based programs, whether universal or targeted, have only shown short-term preventive effects, with lasting long-term benefits elusive. This may in part reflect the dynamic nature of depression, particularly during childhood and youth, which may require ongoing prevention across school years, especially at key transitions and points of stress (e.g. transitions from primary to high school, key exam periods) rather than one-off programs. This is often the case for prevention of physical health conditions. For example, effective skin cancer prevention involves ongoing SunSmart education from early childhood to high school, adjustment of key lifestyle risk factors, screening and extra follow-up for those at high risk (e.g. with family history), as well as daily preventive measures for both students and teachers (e.g. application of sunscreen, protective clothing and indoor play when UV levels are high).

Another key consideration is that student depression is known to be impacted by broader structural school factors such as the school environment (also referred to as ‘school climate’ or ‘school culture’) and teacher wellbeing. It is possible the somewhat limited impact of individual student depression prevention programs to date is in part due to their sole focus on students, without addressing the school environment or climate in which they are embedded. There is a consistent link between school climate (i.e. the socio-cultural factors such as the norms, values, interpersonal relationships and organisational structures within a school) (Jamal et al., Reference Jamal, Fletcher, Harden, Wells, Thomas and Bonell2013; Wang & Degol, Reference Wang and Degol2016) and student outcomes, including mental health (Aldridge & McChesney, Reference Aldridge and McChesney2018). In particular, school climate might be particularly important for transgender and sexually diverse youth, with young people in schools with more positive school climates reporting lower depressive symptoms (Ancheta et al., Reference Ancheta, Bruzzese and Hughes2020). However, there is still more work to be done to clarify the varying definitions of school climate, as well as the use of consistent measurement across studies in the field (Grazia & Molinari, Reference Grazia and Molinari2021; Jessiman et al., Reference Jessiman, Kidger, Spencer, Geijer-Simpson, Kaluzeviciute, Burn, Leonard and Limmer2022), with causal links also yet to be established (Leurent et al., Reference Leurent, Dodd, Allen, Viner, Scott and Bonell2021).

Consideration of teachers’ mental health and wellbeing should also be a key pillar in school-based depression prevention initiatives. Poor teacher wellbeing (including teacher depression) has been shown to negatively impact student outcomes such as poor performance, absenteeism, student depression and other mental health outcomes (Harding et al., Reference Harding, Morris, Gunnell, Ford, Hollingworth, Tilling, Evans, Bell, Grey, Brockman, Campbell, Araya, Murphy and Kidger2019). It has been hypothesised that poor wellbeing and depression in teachers may lead to underperformance at work, which in turn impacts negatively their relationships with students and lead to lower student wellbeing and depression (Harding et al., Reference Harding, Morris, Gunnell, Ford, Hollingworth, Tilling, Evans, Bell, Grey, Brockman, Campbell, Araya, Murphy and Kidger2019). Many teachers report struggling with mental health and report high levels of depression (Agyapong et al., Reference Agyapong, Obuobi-Donkor, Burback and Wei2022). Supporting teacher wellbeing should be a priority for schools and should start at the school leadership level; those teachers who feel valued, are given agency and have meaningful professional development opportunities provided by school leadership report enhanced wellbeing (Cann et al., Reference Cann, Riedel-Prabhakar and Powell2021). There are examples of prevention strategies that combine individual student programs with interventions at the school climate level. For example, a multi-component whole school health promotion intervention (SEHER) run in over 13,000 Indian secondary school students showed moderate to large improvements in depression symptoms, as well as improvements in school climate, compared to students in a control condition over an 8-month period (Shinde et al., Reference Shinde, Weiss, Varghese, Khandeparkar, Pereira, Sharma, Gupta, Ross, Patton and Patel2018). Effects were sustained at 2 years, but only when the intervention was delivered by a lay counsellor (compared to a teacher or control) (Shinde et al., Reference Shinde, Weiss, Khandeparkar, Pereira, Sharma, Gupta, Ross, Patton and Patel2020).

Current challenges and recommendations

For schools

One key challenge for the field of school-based depression prevention is taking effective programs to scale while maintaining preventive effects on depression. This includes examining program mode of delivery, which may be a key factor in improving prevention success. School-based prevention is commonly delivered by school teachers, which has many advantages including the existing relationship with students and low cost associated with delivery compared to the involvement of professionals external to the school. Thus, implementation by teachers may be seen as an equitable model given the variability in schools’ geographic location, access to funds and other resources (Kelly et al., Reference Kelly, Grummitt, Birrell, Stapinski, Barrett, Boyle, Teesson and Newton2021; M. O’Leary-Barrett et al., Reference O’Leary-Barrett, Topper, Al-Khudhairy, Pihl, Castellanos-Ryan, Mackie and Conrod2013). Conversely, teachers are frequently overburdened and time-poor, and program implementation can vary widely depending on teachers’ training, time demands, buy-in and opinion on whether delivery of mental health prevention programs should be within their remit (Baffsky et al., Reference Baffsky, Ivers, Cullen, Wang, McGillivray and Torok2022; Stapinski et al., Reference Stapinski, Lawler, Newton, Reda, Chapman and Teesson2017). Moving forward, if we are to improve upon prevention effects to date, schools and teachers must be better resourced to deliver evidence-based prevention strategies in their schools. This includes supporting existing school staff through training, dedicated funding and time to select, implement and evaluate prevention programs. Alternatively, external prevention facilitators could be commissioned to co-deliver and support the roll-out of evidence-based programs in schools, taking away the burden from a workforce already under significant strain and facing increasing responsibility in their remit. In LMIC settings, non-governmental organisations (NGOs) are key players in delivering supports in schools, including mental health support. In these contexts, it might be particularly important to collaborate with existing NGOs providing as a way of delivering mental health prevention in schools in low-resource settings (Human et al., Reference Human, Loades, Gericke, Laning, Bartlett and Coetzee2024). Either way, it is important that funds and resources are directed to programs with proven benefits and that schools and teachers are supported to deliver these programs at scale, given evidence that prevention programs reduce the incidence of depression by an average of 22% (Cuijpers et al., Reference Cuijpers, van Straten, Smit, Mihalopoulos and Beekman2008).

Table 1. Summary of universal and targeted approaches for school-based depression prevention

We also note the focus of this article has been on the prevention of depression outcomes, noting that schools are rarely so singular in their focus and will look to implement programs with a range of benefits to students. This includes outcomes such as increasing student knowledge, reducing risky behaviours such as substance use and self-harm and improving positive wellbeing.

Recommendations

  • Schools continue to adopt evidence-based whole-school approaches for depression prevention, including a focus on the overall school climate.

  • Schools and teachers are supported in delivering prevention programs, including adequate time, training and funding.

  • Teacher wellbeing is prioritised, alongside student prevention initiatives.

  • Schools select evidence-based programs and collect regular data to evaluate program outcomes.

For researchers and research funders

To date, depression prevention initiatives are frequently developed and evaluated without considering contextual school factors or teacher wellbeing. Future directions may represent a radical change to our approach to the prevention of depression in schools including a move away from discrete programs teaching psychological therapy skills aimed at single disorders (i.e. depression) to strategies that consider environmental, contextual and cultural climates in which prevention programs are delivered (including teachers’ mental health), multiple mental health targets (vs single clinical disorders) and solutions that are designed and delivered in partnership with young people themselves. It is also acknowledged that parents and caregivers play a crucial role in supporting young people’s mental health. While there is a well-established literature on the role of parental attachment, parenting practices and the importance of parental involvement for child mental health treatment in schools (Shucksmith et al., Reference Shucksmith, Jones and Summerbell2010), the involvement of parents in school-delivered mental health prevention is less well understood, and the engagement of parents in school-based prevention has proven challenging.

Given the current state of evidence, there is a pressing need for innovation in school-based prevention of depression outcomes. While targeted programs have demonstrated effectiveness, there is still huge potential to make inroads with universal prevention. This includes more longitudinal research and long-term follow-up studies to better understand mediators and mechanisms of change over time for universal approaches. It is also crucial to better identify the components of effective depression prevention programs, recognising that these may differ from those used in depression treatment programs. Further research is needed to determine whether CBT, mindfulness and other therapeutic skills should play a role in universal preventive contexts or whether these are best confined to targeted prevention and treatment. Another future direction includes testing indirect prevention methods targeting key risk factors for depression in large-scale trials. These risk factors could include sleep, social connection and other lifestyle risk factors for depression.

Finally, prevention designed for young people in schools should be co-designed with young people, alongside educators and those with lived experience. This includes moving beyond broad, consultative, one-way involvement to more meaningful co-design, as well as measuring the impact of participatory involvement on intervention acceptability and effectiveness (Orlowski et al., Reference Orlowski, Lawn, Venning, Winsall, Jones, Wyld, Damarell, Antezana, Schrader, Smith, Collin and Bidargaddi2015). The involvement of young people should also adhere to best practice guidelines on the design and implementation of youth participation (Guo et al., Reference Guo, Meas, Mautner, Yan, Al-Hadaya, Donohoe-Bales, Teesson, Partridge, Simmons, Mandoh, Barrett, Teesson, Smout and Bower2024).

Recommendations

  • A greater understanding is needed to unpack how depression prevention programs operate for different individuals and in different school contexts (i.e. exploring moderators and mediators of intervention effectiveness).

  • Better integration of implementation science methods and co-design principles (i.e. involving key stakeholders, young people and people with lived experience) when evaluating interventions at scale.

  • A greater focus on evaluation and development of prevention programs in LMICs.

  • Indirect prevention initiatives are a promising avenue for further exploration.

  • Selection and implementation of strategies in schools will inevitably be based on the limited resourcing for such programs in schools. Therefore, researchers (and policymakers) should design and prioritise programs with multiple preventive effects on outcomes that are important to schools and that are feasible for schools to implement in real-world conditions.

For policymakers

Prevention of depression through schools will likely require coordination and collaboration across traditionally siloed areas of government. Most notably, depression prevention crosses both health and education and will need a coordinated response involving varying levels of government. To make a meaningful impact on population levels of depression, school environments and school-based initiatives have a key role to play but need to be adequately equipped and resourced to do so. Policymakers should look to increase funding and support for schools to undertake initiatives with scientifically proven benefits. This includes the collection of regular data on depression programs implemented in schools and a focus on early risk factors for depression. In addition, policymakers can actively support schools to implement mental health policy and engage existing NGOs relevant to their national and local contexts. Such collaboration and policy can also influence mental health stigma at a community level, which may be essential for the adoption and uptake of whole-school approaches that seek to engage students, teachers and parents.

Recommendations

  • Increased funding to support implementation of evidence-based prevention in schools (e.g. embedding staff responsible for student welfare (Katz et al., Reference Katz, Griffiths, Bullen and Nethery2014).

  • Funding to support long-term evaluation of school-based prevention and cost-effectiveness studies.

  • Depression prevention (and more broad mental health education) is embedded into pre-service teacher training, so teachers are provided the skills and support to help prevent student mental ill health and have basic awareness of examples of evidence-based prevention strategies, as well as tools to manage their own wellbeing.

In conclusion, schools can play a key role in the prevention of depression. They afford the opportunity to reach a broad range of children and young people in the general population, providing developmentally tailored prevention before the peak period of depression onset. Schools can draw on a range of different strategies for their students, but the most effective are likely to be those encompassed by a whole-school approach that considers contextual and systematic factors, including teacher wellbeing. Future directions include the need to co-design interventions in partnership with young people, teachers and those with lived experience, a greater focus on implementation, moderators and mediators of prevention programs and increased funding to support ongoing implementation, evaluation and long-term follow-up.

Data availability statement

The authors confirm that the data supporting the findings of this study are available within the article.

Author contributions

L.B. and L.G. contributed to the initial conceptualisation, writing, editing and reviewing of this manuscript. H.C. and M.T. contributed to editing and writing after the original draft. L.B. can be contacted for correspondence: .

Financial support

L.B. and M.T. acknowledge support from the National Health and Medical Research Council Investigator Grants. The funders had no input on the current manuscript at any stage.

Competing interests

M.T. is a co-director of Climate Schools Pty Ltd and OurFutures Institute Ltd.

Ethical standards

Ethical approval and consent are not relevant to this article type.

Footnotes

Impact paper in response to the following question: What is the place of universal, selective and indicated prevention strategies for depression and other mood disorders?

References

Connections references

Hickie, IB, Cuijpers, P, Scott, E, Skinner, A, Iorfino, F. What is the place of universal, selective, and indicated prevention strategies for depression and other mood disorders? Research Directions: Depression. 2024;1:e17. doi: https://doi.org/10.1017/dep.2023.29.Google Scholar

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Figure 0

Table 1. Summary of universal and targeted approaches for school-based depression prevention

Author Comment: The place of school-based strategies for universal, selective and indicated prevention for depression — R0/PR1

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Review: The place of school-based strategies for universal, selective and indicated prevention for depression — R0/PR2

Comments

The paper summarizes the existing evidence of different tiers of school-based strategies (universal, targeted, selective, and indicated) to prevent depression. First, authors discussed universal school-based prevention, highlighting limited evidence of lasting long-term positive effects when intervention is delivered at scale. Next, targeted prevention (which includes selective and indicated prevention) is discussed, with meta-analyses and reviews showing more consistent and larger effect sizes compared to universal approaches. Authors, then, report current challenges and make recommendations for schools, for researchers and research funders, and for policy makers. Overall, the paper is well written, comprehensive and informative. Advantages and disadvantages of each tier type, and recommendations for each stakeholder type are clearly listed, thoughtful and actionable.

Here’s a few suggestions:

1. In the recommendations for researchers and research funders, "greater focus on evaluation and development of prevention programs in low- to middle-income countries" is listed. While it is stated that the manuscript only summarizes evidence from high income countries prevention strategies, to give further support to this recommendation, authors could mention global mental health disparities, including access to care and to education. Are there any meta-analyses of school-based interventions for depression in LMICs?

2. Similarly, in the recommendations for researchers and research funders, "better integration of implementation science methods and co-design principles..." is listed. Further emphasis should be placed on the importance of co-designing prevention programs with people with lived experience (which should become a requirement). Are there any school-based depression prevention programs co-designed with people with lived experiences that could be mentioned? How does the effectiveness compare to other programs? A lack would also be interesting and worth noting.

3. An overall conclusion of the paper is missing.

Minor comments:

- Line 74: "CBT" should be spelled out as first occurrence

- Line 89: typo "long-term"

- Line 127: typo "indicated’

- Line 166 and 168: "depression symptoms" should read "depressive symptoms"

- Line 310: outcomes that "are" important to schools, "are" is missing

Recommendation: The place of school-based strategies for universal, selective and indicated prevention for depression — R0/PR3

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Author Comment: The place of school-based strategies for universal, selective and indicated prevention for depression — R1/PR4

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Decision: The place of school-based strategies for universal, selective and indicated prevention for depression — R1/PR5

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