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Lack of association between dopamine D4 receptor gene and personality traits

Published online by Cambridge University Press:  01 July 1998

E. G. JÖNSSON ,
M. M. NÖTHEN ,
J. P. GUSTAVSSON ,
H. NEIDT ,
K. FORSLUND ,
M. MATTILA-EVENDEN ,
G. RYLANDER ,
P. PROPPING  and
M. ÅISBERG
E. G. JÖNSSON
Affiliation:
Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institute, Stockholm, Sweden; and Institute of Human Genetics, University of Bonn, Germany
M. M. NÖTHEN
Affiliation:
Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institute, Stockholm, Sweden; and Institute of Human Genetics, University of Bonn, Germany
J. P. GUSTAVSSON
Affiliation:
Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institute, Stockholm, Sweden; and Institute of Human Genetics, University of Bonn, Germany
H. NEIDT
Affiliation:
Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institute, Stockholm, Sweden; and Institute of Human Genetics, University of Bonn, Germany
K. FORSLUND
Affiliation:
Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institute, Stockholm, Sweden; and Institute of Human Genetics, University of Bonn, Germany
M. MATTILA-EVENDEN
Affiliation:
Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institute, Stockholm, Sweden; and Institute of Human Genetics, University of Bonn, Germany
G. RYLANDER
Affiliation:
Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institute, Stockholm, Sweden; and Institute of Human Genetics, University of Bonn, Germany
P. PROPPING
Affiliation:
Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institute, Stockholm, Sweden; and Institute of Human Genetics, University of Bonn, Germany
M. ÅISBERG
Affiliation:
Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institute, Stockholm, Sweden; and Institute of Human Genetics, University of Bonn, Germany
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Abstract

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Background. Personality traits have shown considerable heritable components. Association between alleles of a polymorphism in the third exon of the dopamine D4 receptor gene (DRD4) and the personality trait Novelty Seeking has been reported. Recently, in a sample of Swedish non-psychiatric subjects we could not detect any significant relationships between the same polymorphism and Novelty Seeking related scales in the Karolinska Scales of Personality (KSP). However, there was a tendency in the direction of the proposed association. There were also tentative associations between an exon I 13 bp deletion polymorphism and the personality traits Socialization and Guilt.

Methods. We investigated a new Swedish population-based sample (N=167) investigated with the KSP for three DRD4 polymorphisms.

Results. Neither of the previous results were replicated. Combining the previous and the present samples did not give rise to any significant association between DRD4 polymorphisms and personality scales.

Conclusions. The dopamine D4 receptor gene is probably not of importance to the different personality dimensions as measured by the Karolinska Scales of Personality.

Type
Brief Communication
Information
Psychological Medicine , Volume 28 , Issue 4 , July 1998 , pp. 985 - 989
Copyright
© 1998 Cambridge University Press