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Clinical and neuropsychological characteristics of child and adolescent bipolar disorder

Published online by Cambridge University Press:  28 March 2006

ZOË A. KYTE ,
GABRIELLE A. CARLSON  and
IAN M. GOODYER
ZOË A. KYTE
Affiliation:
Developmental Psychiatry Section, University of Cambridge, UK
GABRIELLE A. CARLSON
Affiliation:
Department of Psychiatry and Behavioural Sciences, Stony Brook University School of Medicine, New York, USA
IAN M. GOODYER
Affiliation:
Developmental Psychiatry Section, University of Cambridge, UK
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Abstract

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Background. The diagnosis of bipolar disorder in pre-pubertal populations remains difficult and often controversial. Consequently, the clinical and neuropsychological characteristics of mania in the child and adolescent years remain poorly defined. This review provides a clinical account of childhood and adolescent bipolar disorder and compares the neuropsychology and neuroanatomy of young BPD patients compared with adult BPD and childhood syndromes of attention deficit hyperactivity disorder (ADHD) and conduct disorder (CD).

Method. Literature review based on Pubmed searches.

Results. Early- and adult-onset mania and BPD may share a common pattern of neurobiological characteristics despite developmental variations in the clinical presentation. In contrast, important distinctions are apparent between the child-onset syndromes of BPD, ADHD and CD, specifically at the neural level.

Conclusions. Disorders of affect dysregulation in childhood deserve closer neuroscientific and phenotypic scrutiny than given hitherto.

Type
Review Article
Information
Psychological Medicine , Volume 36 , Issue 9 , September 2006 , pp. 1197 - 1211
Copyright
2006 Cambridge University Press