Hostname: page-component-6bf8c574d5-b4m5d Total loading time: 0 Render date: 2025-02-14T09:14:21.320Z Has data issue: false hasContentIssue false
  • English
  • Français

Cerebral ventricular size in depressed subjects

Published online by Cambridge University Press:  09 July 2009

R. J. Dolan ,
S. P. Calloway  and
A. H. Mann
R. J. Dolan*
Affiliation:
Academic Department of Psychiatry, Royal Free Hospital, London
S. P. Calloway
Affiliation:
Academic Department of Psychiatry, Royal Free Hospital, London
A. H. Mann
Affiliation:
Academic Department of Psychiatry, Royal Free Hospital, London
*
1Address for correspondence: Dr R. J. Dolan,The Maudsley Hospital, Denmark Hill, London SE5 8AZ.
Get access Rights & Permissions [Opens in a new window]

Synopsis

A computed tomographic study of 101 depressed patients and 52 normal control subjects is described. Increasing age and male sex were both associated with larger ventricular size in both patient and control groups. Controlling for these effects, the depressed patients had larger ventricles than the control subjects. In the patient group there was no association between ventricular size, course of illness or exposure to drug treatment or electroconvulsive therapy.

Type
Research Article
Information
Psychological Medicine , Volume 15 , Issue 4 , November 1985 , pp. 873 - 878
Copyright
Copyright © Cambridge University Press 1985

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Andreasen, N. C., Smith, M. R., Jacoby, C. G., Dennert, J. W. & Olsen, S. A. (1982 a). Ventricular enlargement in schizophrenia: definition and prevalence. American Journal of Psychiatry 139, 292–296.Google Scholar
Andreasen, N. C., Olsen, S. A., Dennert, J. W. & Smith, M. R. (1982 b). Ventricular enlargement in schizophrenia: relationship to positive and negative symptoms. American Journal of Psychiatry 139, 297–302.Google ScholarPubMed
Barron, S. G., Jacobs, L. & Kirkel, W. R. (1976). Changes in size of lateral ventricles during ageing determined by computerized tomography. Neuroradiology 26, 1011–1013.Google ScholarPubMed
Crow, T. J. (1980). Molecular pathology of schizophrenia: more than one disease process? British Medical Journal 280, 66–68.Google Scholar
Frangos, E. & Athanassenas, G. (1982). Differences in lateral brain ventricular size among various types of chronic schizophrenics: evidence based on a CT scan. Acta Psychiatrica Scandinavica 66, 459–463.CrossRefGoogle Scholar
Golden, C. J., Moses, J. A. Jr, Zelazowski, R., Graber, B., Zatz, L. M., Horvath, T. B. & Berger, P. A. (1980). Cerebral ventricular size and neuropsychological impairment in young chronic schizophrenics: measurement by the standardised Luria-Nebraska Neuropsychological Battery. Archives of General Psychiatry 37, 619–623.CrossRefGoogle ScholarPubMed
Gyldensted, C. (1977). Measurements of the normal ventricular system and hemispheric sulci of 100 adults with computed tomography. Neuroradiology 14, 183–192.CrossRefGoogle ScholarPubMed
Haug, G. (1977). Age and sex dependence of the size of normal ventricles on computed tomography. Neuroradiology 10, 205–213.Google Scholar
Hull, H. C. & Nie, H. H. (1981). SPSS Update 7–9: New Procedures and Facilities for Releases 7–9. McGraw-Hill: New York.Google Scholar
Jacoby, R. J. & Levy, R. (1980). Computed tomography in the elderly: 3. Affective disorder. British Journal of Psychiatry 136, 270–275.CrossRefGoogle ScholarPubMed
Jacoby, R. J., Levy, R. & Bird, J. M. (1981). Computed tomography and the outcome of affective disorder: a follow-up study of elderly patients. British Journal of Psychiatry 139, 288–292.CrossRefGoogle ScholarPubMed
Jernigan, T. L., Zatz, L. N., Moses, J. A. & Berger, P. A. (1982). Computed tomography in schizophrenia and normal volunteers. I. Fluid volume. Archives of General Psychiatry 39, 765–770.CrossRefGoogle ScholarPubMed
Johnstone, E. C., Crow, T. J., Frith, C. D., Husband, J. & Kreel, L. (1976). Cerebral ventricular size and cognitive impairment in schizophrenia. Lancet ii, 924–926.CrossRefGoogle Scholar
Nasrallah, H. A., McCalley-Whitters, M. & Jacoby, C. G. (1982). Cerebral ventricular enlargement in young manic males: a controlled CT study. Journal of Affective Disorders 4, 15–19.Google Scholar
Nie, N. H., Hull, C. H., Jenkins, J. G., Steinberger, K. & Dale, B. H. (1975). SPSS: Statistical Package for the Social Sciences (2nd edn). McGraw-Hill: New York.Google Scholar
Pearlson, G. D. & Veroff, A. E. (1981). Computerised tomographic scan changes in manic depressive illness. Lancet ii, 470.CrossRefGoogle Scholar
Reveley, A. M., Reveley, M. A. & Murray, R. M. (1984). Cerebral ventricular enlargement in non-genetic schizophrenia: a controlled twin study. British Journal of Psychiatry 144, 89–93.Google Scholar
Reveley, M. A. (1983). The measurement of cerebral ventricular volume: a comparison of computerised and planimetric methods.Paper presented to the Royal College of Psychiatrists,London,November 1983.Google Scholar
Rieder, R., Mann, L. S., Weinberger, D. R., van Kammen, D. P. & Post, R. M. (1983). Computed tomographic scans in patients with schizophrenia, schizo-affective and bipolar affective disorder. Archives of General Psychiatry 40, 735–739.CrossRefGoogle Scholar
Scott, M. L., Golden, C. J., Ruedrich, S. L. & Bishop, R. J. (1983). Ventricular enlargement in major depression. Psychiatry Research 8, 91–93.CrossRefGoogle ScholarPubMed
Spitzer, R. L., Endicott, J. & Robins, E. (1978). Research Diagnostic Criteria. Rationale and reliability. Archives of General Psychiatry 35, 773–782.Google Scholar
Weinberger, D. R., Torrey, E. F., Neophytides, A. N. & Wyatt, R. J. (1979). Lateral cerebral ventricular enlargement in chronic schizophrenia. Archives of General Psychiatry 36, 735–739.Google Scholar
Wing, J. K., Cooper, J. E. & Sartorius, N. (1974). The Measurement and Classification of Psychiatric Symptoms. Cambridge University Press: Cambridge.Google Scholar