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Aberrant interleukin-2 receptor-mediated blastoformation of peripheral blood lymphocytes in a severe major depressive episode

Published online by Cambridge University Press:  01 March 1998

S. KANBA ,
H. MANKI ,
F. SHINTANI ,
Y. OHNO ,
G. YAGI  and
M. ASAI
S. KANBA
Affiliation:
From the Department of Neuropsychiatry, Yamanashi Medical University, Yamanashi-ken and Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan
H. MANKI
Affiliation:
From the Department of Neuropsychiatry, Yamanashi Medical University, Yamanashi-ken and Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan
F. SHINTANI
Affiliation:
From the Department of Neuropsychiatry, Yamanashi Medical University, Yamanashi-ken and Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan
Y. OHNO
Affiliation:
From the Department of Neuropsychiatry, Yamanashi Medical University, Yamanashi-ken and Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan
G. YAGI
Affiliation:
From the Department of Neuropsychiatry, Yamanashi Medical University, Yamanashi-ken and Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan
M. ASAI
Affiliation:
From the Department of Neuropsychiatry, Yamanashi Medical University, Yamanashi-ken and Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan
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Abstract

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Background. We examined interleukin-2 (IL-2) related immune pathways in depression to elucidate mechanisms underlying various immunological disturbances associated with depression.

Methods. Subjects comprised 35 unmedicated patients with a major depressive episode without psychotic features and 36 age- and sex-matched healthy volunteers. The immune parameters examined included the numbers of B and T cells, IL-2 receptor-mediated blastoformation (IL-2R-mediated blastoformation), IL-2 production and expression of the IL-2 receptor α-subunit.

Results. The patients with a severe episode showed significantly lower IL-2R-mediated blastoformation than the controls. There was a statistically significant negative correlation between IL-2R-mediated blastoformation and the severity of depression at the time of entry.

Conclusion. The reduced IL-2R-mediated blastoformation may partly explain several previously reported abnormal immune functions associated with depression.

Type
BRIEF COMMUNICATION
Information
Psychological Medicine , Volume 28 , Issue 2 , March 1998 , pp. 481 - 484
Copyright
© 1998 Cambridge University Press