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Predicting inbreeding using markers and long-term genetic contributions

Published online by Cambridge University Press:  20 November 2017

J. Hernandez-Sanchez ,
C. S. Haley  and
J. A. Woolliams
J. Hernandez-Sanchez
Affiliation:
Roslin Institute, Roslin, Midlothian, EH25 9PS, Scotland, UK
C. S. Haley
Affiliation:
Roslin Institute, Roslin, Midlothian, EH25 9PS, Scotland, UK
J. A. Woolliams
Affiliation:
Roslin Institute, Roslin, Midlothian, EH25 9PS, Scotland, UK
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Extract

Quantitative Trait Loci (QTLs) are chromosomal regions containing genes causing variation in continuous traits. Two alleles are Identical-By-Descent (IBD) if they are copies of the same original allele. For each point on a chromosome, it is possible to predict IBD probabilities among individuals given a pedigree and marker information and use them to map QTLs in farmed species. Pedigree founders can either be assumed unrelated (George et al. 2000) or related through distant common ancestors (Meuwissen and Goddard 2000). The relationship among founders was estimated through simulating the history of a model population. Linking the current population with original ancestors, without a pedigree, is central to the theory of long-term genetic contributions (Bijma 2000). Hence, in the light of this theory, it should be possible to deterministically predict IBD relationships among pedigree founders. A first step towards this objective was predicting inbreeding (F) within each animal at a chromosomal location.

Type
Theatre Presentations
Information
Proceedings of the British Society of Animal Science , Volume 2002 , 2002 , pp. 58
Copyright
Copyright © The British Society of Animal Science 2002

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References

Bijma, P. (2000) “Long-term genetic contributions: prediction of rates of inbreeding and genetic gain in selected populations” Ph. D. Thesis, Dept. of Animal Sciences, Wageningen, The Netherlands Google Scholar
George, A. W., Visscher, P. M. and Haley, C. S. (2000) “Mapping Quantitative Trait Loci in complex pedigrees: a two-step variance component approach” Genetics 156: 2081–2092 CrossRefGoogle ScholarPubMed
Meuwissen, T. H. E. and GoddardM, E. (2000) “Fine mapping of quantitative trait loci using linkage disequilibria with closely linked marker loci” Genetics 155: 421–430 CrossRefGoogle ScholarPubMed