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Plasma concentrations of glucagon-like peptide-1 and cholecystokinin in sheep are altered by the amount of dry matter intake and the addition of fat to the diet

Published online by Cambridge University Press:  23 November 2017

A. E. Relling ,
B. J. Lengacher ,
S. C. Loerch  and
C. K. Reynolds
A. E. Relling
Affiliation:
The Ohio State University, Wooster, OH, United States
B. J. Lengacher
Affiliation:
The Ohio State University, Wooster, OH, United States
S. C. Loerch
Affiliation:
The Ohio State University, Wooster, OH, United States
C. K. Reynolds*
Affiliation:
University of Reading, Reading, United Kingdom
*
Email:c.k.reynolds@reading.ac.uk
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Extract

Dry matter intake (DMI) regulation is important in ruminants as DMI is a major determinant of milk and meat production. It is known that the gut peptides glucagon-like peptide-17, 36 amide (GLP-1) and cholecystokinin-8 (CCK) can reduce DMI in nonruminants (Walsh, 1994). In ruminants, there is little information on the function or effects of diet on plasma concentrations of these peptides. Previous studies have shown that supplemental dietary fat (Relling and Reynolds, 2007b) increases plasma concentrations of GLP-1 and CCK and decreases DMI. In contrast, increased metabolizable energy intake (MEI) in early lactation also increases GLP-1 and CCK concentration in dairy cows (Relling and Reynolds, 2007a). Therefore, our objective was to determine if plasma concentrations of GLP-1 and CCK are affected by supplemental fat, and if the response differs for ad libitum versus restricted DMI.

Type
Theatre Presentations
Information
Proceedings of the British Society of Animal Science , Volume 2008 , 2008 , pp. 126
Copyright
Copyright © The British Society of Animal Science 2008

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References

Relling, A. E. and Reynolds, C. K.. 2007a. Journal of Dairy Science 90, 325–330.Google Scholar
Relling, A. E. and Reynolds, C. K.. 2007b. Journal of Dairy Science 90, 1506–1515.Google Scholar
Walsh, J. 1994. Gastrointestinal hormones. In Physiology of the Gastrointestinal Tract, Vol. 2008, 3rd Ed. (ed. Johnson, L. R., Christensen, J., Jacobson, E. D., and Walsh, J. H.), pp. 1–129, Raven Press, New York, NY.Google Scholar