Hostname: page-component-6bf8c574d5-xtvcr Total loading time: 0 Render date: 2025-02-22T19:18:02.275Z Has data issue: false hasContentIssue false
  • English
  • Français

Leptin and its receptors: Modulation of the neuroendocrine axis

Published online by Cambridge University Press:  20 November 2017

K.L. Houseknecht
K.L. Houseknecht*
Affiliation:
Department of Cardiovascular and Metabolic Diseases, Pfizer Global Research and Development, Groton, Connecticut 06475, USA
Get access

Extract

Leptin is a 16 kDa protein synthesized and secreted primarily by adipocytes. Leptin was discovered in 1994 as the gene product deficient in the obese ob/ob mouse. In addition to profound obesity, these animals are characterized by multiple, complex neuroendocrine disorders that manifest in severe insulin resistance and infertility. We now know that leptin is involved in the regulation of appetite, body weight, energy balance, reproduction and the neuroendocrine axis in animals and man. Additionally, leptin has been shown to regulate immune function and anorexia associated with disease.

Type
Invited Theatre Presentations
Information
Proceedings of the British Society of Animal Science , Volume 2002 , 2002 , pp. 229
Copyright
Copyright © The British Society of Animal Science 2002

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L. and Friedman, J.M. 1994. Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425–432.Google Scholar
Houseknecht, K.L., Portocarrero, C.P. 1998. Leptin and its receptors: regulators of whole-body energy homeostasis. Domest. Anim,. Endocrinol. 15: 457–475.CrossRefGoogle ScholarPubMed
Ahima, R.S., Saper, C.B., Flier, J.S. and Elmquist, J.K. 2000. Leptin regulation of neuroendocrine systems. Front. Neuroendocrinol. 21: 263–307.Google Scholar