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Genome scan to detect quantitative trait loci for economically important traits in Holstein cattle using a dense SNP map

Published online by Cambridge University Press:  22 November 2017

H.D. Daetwyler ,
F.S. Schenkel ,
M. Sargolzaei  and
J.A.B. Robinson
H.D. Daetwyler*
Affiliation:
Roslin Institute, Roslin, Midlothian, United Kingdom
F.S. Schenkel
Affiliation:
University of Guelph, Guelph, Ontario, Canada
M. Sargolzaei
Affiliation:
University of Guelph, Guelph, Ontario, Canada
J.A.B. Robinson
Affiliation:
University of Guelph, Guelph, Ontario, Canada
*
Email:hans.daetwyler@bbsrc.ac.uk
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Extract

Quantitative trait loci (QTL) are chromosome regions which are significantly associated with the expression of a phenotypic trait in a particular population. Detection of a QTL is carried out using association with a genetic marker, such as a single nucleotide polymorphism (SNP), which is in linkage disequilibrium (LD) with the QTL. The two main categories of association studies are linkage analyses (LA), which consider LD within families and linkage disequilibrium methods, which make use of LD across an entire population. The recent reduction in genotyping costs has allowed for testing individuals for a large number of SNP. This substantial increase in genotypic data has lead to denser marker distributions on the bovine genome thus potentially increasing the power of QTL detection studies. The objective of this study was to scan the bovine genome to detect QTL for 305 day lactation milk yield (MY), 305 day lactation fat yield (FY), 305 day lactation protein yield (PY), herd life (HL), somatic cell score (SCS), interval from calving to first service in cows (CTFS) and age at first service in heifers (AFS). HL is a measure of longevity measured in the number of lactations a cow stays in the herd. SCS refers to the amount of somatic cells a cow has in her milk and is an important indicator trait for mastitis. CTFS is the period from parturition to first insemination in days and AFS is the age in days at which a heifer was artificially inseminated for the first time. Fertility traits, such as CTFS and AFS, are indicators of reproductive efficiency.

Type
Theatre Presentations
Information
Proceedings of the British Society of Animal Science , Volume 2007 , April 2007 , pp. 6
Copyright
Copyright © The British Society of Animal Science 2007

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References

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