Field observations suggest an increased incidence of digestive disorders (e.g. non-specific colitis) when growing pigs are offered diets containing high levels of wheat, particularly when the diet is offered in pellet rather than in meal form. This may be due to the anti-nutritive effects of wheat non-starch polysaccharides, with the possibility that such effects are increased following diet processing. Additionally, the provocative effects of wheat on digestive disorders may involve a change in gut microbial balance, which in turn may influence the production of fermentation end products such as skatole. High skatole concentrations (> 0.2 ppm) in carcass fat can adversely influence the sensory quality of pig meat. In this study the aim was to evaluate the effect of diet processing and feed enzyme (xylanase) supplementation of wheat based diets on the performance, general health and carcass skatole levels in growing pigs.