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Juvenile female Litomosoides sigmodontis produce an excretory/secretory antigen (Juv-p120) highly modified with dimethylaminoethanol

Published online by Cambridge University Press:  01 September 1998

M. HINTZ ,
G. SCHARES ,
A. TAUBERT ,
R. GEYER ,
H. ZAHNER ,
S. STIRM  and
F. J. CONRATHS
M. HINTZ
Affiliation:
Biochemisches Institut am Klinikum, Justus-Liebig-Universität, Friedrichstrasse 24, D-35392 Gießen, Germany
G. SCHARES
Affiliation:
Institut für Parasitologie, Justus-Liebig-Universität, Rudolf-Buchheim-Strasse 2, D-35392 Gießen, Germany
A. TAUBERT
Affiliation:
Institut für Parasitologie, Justus-Liebig-Universität, Rudolf-Buchheim-Strasse 2, D-35392 Gießen, Germany
R. GEYER
Affiliation:
Biochemisches Institut am Klinikum, Justus-Liebig-Universität, Friedrichstrasse 24, D-35392 Gießen, Germany
H. ZAHNER
Affiliation:
Institut für Parasitologie, Justus-Liebig-Universität, Rudolf-Buchheim-Strasse 2, D-35392 Gießen, Germany
S. STIRM
Affiliation:
Biochemisches Institut am Klinikum, Justus-Liebig-Universität, Friedrichstrasse 24, D-35392 Gießen, Germany
F. J. CONRATHS
Affiliation:
Institut für Parasitologie, Justus-Liebig-Universität, Rudolf-Buchheim-Strasse 2, D-35392 Gießen, Germany
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Abstract

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A 120 kDa antigen produced by juvenile female Litomosoides sigmodontis (Juv-p120) was isolated and purified. The amino acid composition of the molecule was determined. Juv-p120 was shown to be highly modified with N,N-dimethyl-aminoethanol (28·4 mol%). Treatment of Juv-p120 with potassium hydroxide (β-elimination) or with sodium m-periodate leads to the destruction of epitopes recognized by antibodies immune affinity-purified with isolated Juv-p120. Juvenile L. sigmodontis were shown to release Juv-p120 into the pleural cavity of infected Mastomys coucha before the onset of patency.

Keywords

Litomosoides sigmodontisfilariasisexcretory/secretory productsdimethylaminoethanol
Type
Research Article
Information
Parasitology , Volume 117 , Issue 3 , September 1998 , pp. 265 - 271
Copyright
1998 Cambridge University Press