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Infection with Leishmania major stimulates haematopoiesis in susceptible BALB/c mice and suppresses haematopoiesis in resistant CBA mice

Published online by Cambridge University Press:  10 March 2003

V. O. GUILPIN ,
L. NOSBISCH ,
R. G. TITUS  and
C. J. SWARDSON-OLVER
V. O. GUILPIN
Affiliation:
Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523-1619, USA Current address: Aventis Pharma, 13 Quai Jules, 94403 Vitry Sur Seine, Cedex, France.
L. NOSBISCH
Affiliation:
Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523-1619, USA
R. G. TITUS
Affiliation:
Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523-1619, USA
C. J. SWARDSON-OLVER
Affiliation:
Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523-1619, USA
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Abstract

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Cytokine responses to Leishmania infection begin very early in infection, and differ between susceptible and resistant mice. Susceptibility to chronic Leishmania infection has been associated with increased haematopoiesis. To analyse the effect that acute infection with L. major has on bone-marrow haematopoiesis in susceptible (BALB/c) and resistant (CBA) mice, we enumerated erythroid progenitors and granulocyte-monocyte progenitors 3 days after infection. We found that haematopoiesis was stimulated in BALB/c mice infected with L. major, while haematopoiesis was inhibited in CBA mice. We found that this effect could be partially explained by cytokine production: interleukin-4 was involved in stimulation of BALB/c haematopoiesis and tumour necrosis factor-α was involved in inhibition of CBA haematopoiesis. Our conclusions are that haematopoietic changes occur shortly after L. major infection, and may be related to disease outcome.

Keywords

Leishmania majorprotozoan parasitemousehaematopoiesisinterleukin-4tumour necrosis factor-alpha
Type
Research Article
Information
Parasitology , Volume 126 , Issue 3 , March 2003 , pp. 187 - 194
Copyright
2003 Cambridge University Press