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Bioactive Molecules Delivered by Ceramic Nanoparticles Coated with a Film of Polyhydroxyl Oligomers

Published online by Cambridge University Press:  21 February 2011

Nir Kossovsky
Nir Kossovsky*
Affiliation:
Biomaterials Bioreactivity Characterization Laboratory, Department of Pathology and Laboratory Medicine, University of California, Los Angeles, 90024–1732
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Abstract

The structural denaturation of polypeptides and other macromolecular pharmaceuticals upon surface adsorption from an aqueous environment is almost inevitable. Molecular denaturation, coupled with a net increase in entropy, accounts for the net negative ΔG and frequent irreversible nature of surface adsorption. The consequence of this interaction is that surface immobilized drugs lose their dynamic freedom and thus, all too often, their biological activity.

This phenomenon has complicated the development of drug delivery vehicles. In this communication, a drug delivery system based on a novel surface modification process to help reverse the constraining activity of surfaces is described. Beginning with preformed carbon ceramic nanoparticles and self-assembled calcium-phosphate dihydrate particles (colloidal precipitation) to which glassy carbohydrates are then allowed to adsorb as a nanometer thick surface coating, a molecular carrier is formed. The carbohydrate coating functions as a dehydroprotectant and stabilizes subsequently non-covalently bound immobilized members of biochemically reactive surface members such as pharmaceuticals.

Many of the physical properties of this enabling system have been characterized in vitro and in animal models. Antigen delivery, drug delivery, and enzyme stabilization experiments are described.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 394: Symposium Z – Polymers in Medicine and Pharmacy , 1995 , 67
Copyright
Copyright © Materials Research Society 1995

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