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Radiation induced liver disease: is hereditary haemochromatosis a risk factor?

Published online by Cambridge University Press:  20 November 2006

R. M. Laurie ,
M. W. T. Chao  and
C. A. Dow
R. M. Laurie
Affiliation:
Dorevitch Pathology, Heidelberg, Victoria, Australia
M. W. T. Chao
Affiliation:
Western Private Hospital, Footscray, Victoria, Australia
C. A. Dow
Affiliation:
Western Private Hospital, Footscray, Victoria, Australia
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Abstract

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A 71-year-old man with Stage II gastric cancer developed rapid onset radiation induced liver disease after ceasing adjuvant chemotherapy and radiotherapy. Autopsy revealed moderate hepatocellular iron overload. Posthumously, he was found to be a compound heterozygote for hereditary haemochromatosis. Since both radiation and iron overload may induce liver damage through the activation of hepatic stellate cells, it is possible that hepatocellular iron overload may potentiate the effects of irradiation and predispose the patient to radiation induced liver disease.

Keywords

Radiation induced liver diseaseveno-occlusive diseaseiron overloadhereditary haemochromatosishepatic stellate cells
Type
Case Study
Information
Journal of Radiotherapy in Practice , Volume 3 , Issue 2 , March 2003 , pp. 101 - 104
Copyright
2003 Cambridge University Press