This paper analyses Ghanaian electoral geography and its accompanying political party variations over the last decade. After re-democratisation in the early 1990s, the Fourth Republic of Ghana has successfully completed multiple elections and party alternation. Due to its single-member-district-plurality electoral system, the country has functioned virtually as a two-party system, privileging its two major parties – the NDC and the NPP. However, close examination of election results in the last parliamentary and presidential elections reveals that notwithstanding the two-party tendency, there is a dynamic and multilayered aspect of electoral participation in Ghanaian politics. Ethnic-based regional cleavages show much more complex varieties of electoral support for the two major parties, especially in light of fragmentation and concentration. Electoral support in the ten regions varies from strong one-party-like to almost three-party systems. Yet this lower, regional level tendency is not invariable. Regional party strengths have shifted from election to election, and it was just such shifts that made the party alternation possible in 2000. Employing traditional and newly designed indicators, this paper illustrates the patterns of electoral cleavage and regional party organisation, and how these ultimately sustain the party system at the national level in Ghana.