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Use of a Modified Takata Reaction in the Examination of the Cerebrospinal Fluid of Certain Psychoses

Published online by Cambridge University Press:  08 February 2018

H. H. Fleischhacker
H. H. Fleischhacker*
Affiliation:
From the Pathological Laboratory, Shenley Hospital, Middlesex County Council
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The Takata reaction has hitherto been mainly applied as a serum protein test and has been claimed useful in the diagnosis of liver disease.

It has been modified and applied to the cerebrospinal fluid (Takata-Ara (1)). Preliminary investigators found positive results in syphilis of the central nervous system, and it was thought to be a characteristic of this condition. Subsequent workers, however, found that organic conditions other than neuro-syphilis produced similar positive reactions, with the result that the test fell somewhat into disrepute. Now, however, it seems to be established that the test is indicative of a change in the albumin-globulin (euglobulin) ratios in the cerebrospinal fluid. This condition is mainly found in syphilis of the central nervous system, but occurs, of course, in other conditions affecting the central nervous system, especially where degenerative processes are involved.

Type
Part I.—Original Articles
Information
Journal of Mental Science , Volume 89 , Issue 375 , April 1943 , pp. 297 - 304
Copyright
Copyright © Royal College of Psychiatrists, 1943 

References

(1) Takata-Ara, (1926), Liquorreaktion. Tokyo.Google Scholar
(2) Fleischhacker, (1938), J. Ment. Sci., 84, 378.Google Scholar
(3) Kafka, and Samson, (1928), Z. Neurol., 115, 85.Google Scholar
(4) Neel, , Askgaard, and Hahnemann, (1933), Acta psych. et neurol., 8, 609.Google Scholar
(5) Neel, (1939), The Content of Cells and Proteins in the Normal Cerebrospinal Fluid. Copenhagen and London.Google Scholar
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