Hostname: page-component-745bb68f8f-s22k5 Total loading time: 0 Render date: 2025-02-05T17:54:05.733Z Has data issue: false hasContentIssue false

Stelazine (Trifluoperazine) A Preliminary Report on a Clinical Trial

Published online by Cambridge University Press:  08 February 2018

J. R. A. Madgwick
Affiliation:
Long Grove Hospital, Epsom, Surrey
Desmond L. M. McNeill
Affiliation:
Long Grove Hospital, Epsom, Surrey
Marie Driver
Affiliation:
Long Grove Hospital, Epsom, Surrey
George C. Preston
Affiliation:
Long Grove Hospital, Epsom, Surrey
Rights & Permissions [Opens in a new window]

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Trifluoperazine, which is 2-trifluoromethyl-10-(3′-[1″-methylpiperazinyl-4″]-propyl)-phenothiazine dihydrochloride—a preparation manufactured by Smith, Kline and French Laboratories Limited under the description SKF5019—is the most recent phenothiazine derivative reported to have a beneficial effect on certain types of mental illness. On the basis of animal tests trifluoperazine is described as having nine times the potency of chlorpromazine in blocking the conditioned response, and its specificity is greater than that of chlorpromazine.

Type
Original Articles
Copyright
Copyright © Royal College of Psychiatrists, 1958 

References

Rudy, L. H., et al., Amer. J. Psych., 1958, 114, 747.CrossRefGoogle Scholar
Submit a response

eLetters

No eLetters have been published for this article.