Two papers have recently appeared in the Journal indicating a causal relationship between indoxyluria, alimentary toxæmia, and melancholia. One paper, published by Arthur A. D. Townsend in January, 1905 (Journal of Mental Science, 1905, p. 51), is entitled “Mental Depression and Melancholia, considered in regard to Auto-intoxication, with Special Reference to the Presence of Indoxyl in the Urine and its Clinical Significance”; the other paper, published by Lewis C. Bruce in July, 1906 (Journal of Mental Science, 1906, p. 501), bears the title “The Clinical Significance of Indoxyl in the Urine.”