There can hardly be a psychiatrist in this country who has not produced parkinsonism in his schizophrenics with reserpine or phenothiazines: Moore, who was among the first in the field in the use of reserpine, spoke of the parkinsonian syndrome, but there was one observation of his that received only passing attention, This was that a small number of his chronic schizophrenics lost their florid schizophrenic symptoms, to be replaced by a clinical picture that he found closely akin to retarded endogenous depression, to the point of contemplated or attempted suicide.