A. D. Q— was admitted into Armentières Asylum, September 14th, 1888, at the age of 39. His early symptoms began apparently after the death of his wife about four months before; he was depressed, said he couldn't eat, that he was dead, left off working, and stayed in bed. On admission he presented all the signs of general paralysis of the melancholic type, with delusions of negation. The disease progressed rapidly, and he died in January, 1889.