The rôle of focal sepsis as a causative factor in mental disease has received increasing attention during the past few years since Cotton published his results in this field of inquiry (Journal of Mental Science, October, 1923). In England, prominent workers in this branch of medicine, while unable to report the striking therapeutic results of Cotton, have confirmed his main contention that many acute and subacute psychoses seem to be intimately related to some focus of sepsis. Thus confirmation of this main thesis has come from Graves (Journ. Ment. Sci., October, 1923 and 1925), Chalmers Watson (ibid., October, 1923), Hunter and Moynihan (Brit. Med. Journ., November 5, 1927). On the other hand, equally prominent psychiatrists have called in question the results claimed, and the alleged “proven relationship” of sepsis and mental disorder, chief among whom are Henderson and Menzies (Brit. Med. Journ., November 5, 1927, p. 818).