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A Controlled Comparative Investigation of the Effects of Promazine, Chlorpromazine, and a Placebo in Chronic Psychosis

Published online by Cambridge University Press:  08 February 2018

B. G. Fleming ,
A. M. Spencer  and
E. M. Whitelaw
B. G. Fleming
Affiliation:
Powick Hospital, near Worcester
A. M. Spencer
Affiliation:
Powick Hospital, near Worcester
E. M. Whitelaw
Affiliation:
Powick Hospital, near Worcester
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Tranquillizing drugs have become widely accepted as a major form of treatment in psychiatry. However, reports in the literature on these drugs have frequently been conflicting, with a marked tendency for the results of uncontrolled studies to be much more favourable than those obtained in studies where some method of control has been adopted. Sargant (1956) has emphasized many of the social, economic, and moral implications inherent in the extravagant and indiscriminate use of tranquillizers in general and has stressed the need for the proper evaluation of their therapeutic effects. In view of this need, we undertook a controlled comparative study of the effects of two of the phenothiazine compounds, promazine (“Sparine”) and chlorpromazine (“Largactil”), in the treatment of chronic psychosis.

Type
Original Articles
Information
Journal of Mental Science , Volume 105 , Issue 439 , April 1959 , pp. 349 - 358
Copyright
Copyright © Royal College of Psychiatrists, 1959 

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