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Treatment of primary mucosal head and neck squamous cell carcinoma using photodynamic therapy: results after 25 treated cases

Published online by Cambridge University Press:  08 March 2006

M. G. Dilkes ,
E. Benjamin ,
S. Ovaisi  and
A. S. Banerjee
M. G. Dilkes
Affiliation:
Department of Otolaryngology - Head and Neck Surgery, St Bartholomew’s Hospital, West Smithfield, London, UK.
E. Benjamin
Affiliation:
Department of Otolaryngology - Head and Neck Surgery, St Bartholomew’s Hospital, West Smithfield, London, UK.
S. Ovaisi
Affiliation:
Department of Otolaryngology - Head and Neck Surgery, St Bartholomew’s Hospital, West Smithfield, London, UK.
A. S. Banerjee
Affiliation:
Department of Otolaryngology - Head and Neck Surgery, St Bartholomew’s Hospital, West Smithfield, London, UK.
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Abstract

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The use of photodynamic therapy for the treatment of malignant and non-malignant conditions is increasing. This paper demonstrates the efficacy of a second-generation photosensitizer, Foscan®, in the primary treatment of a wide range of mucosal head and neck squamous cell carcinomas. Tumours ranged in stage from T1 to T3. A complete response to primary treatment was seen in 19/21 patients (90 per cent). In laryngeal cancer recurrent after radical radiotherapy, one out of four patients treated obtained a complete response (25 per cent). Six patients (24 per cent) required surgery after photodynamic therapy, for local recurrence or dysplasia. Mean follow up was for 27.3 months (standard deviation 20.6 months).

Keywords

Head and Neck NeoplasmsPhotochemotherapyTreatment Outcome
Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 117 , Issue 9 , September 2003 , pp. 713 - 717
Copyright
© Royal Society of Medicine Press Limited 2003