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Topical vancomycin for chronic suppurative otitis media with methicillin-resistant Staphylococcus aureus otorrhoea

Published online by Cambridge University Press:  08 March 2006

Chul Ho Jang
Affiliation:
Department of Otolaryngology, Wonkwang University Hospital, Wonkwang Medical School, Iksan, Korea.
Chang-Hun Song
Affiliation:
Medical Research Center, Chosun University, Gwangju, Korea.
Pa-Chun Wang
Affiliation:
Department of Otolaryngology, Cathay General Hospital,Taipei, Taiwan.
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Abstract

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There has been a steady increase in the number of cases of methicillin-resistant Staphylococcus aureus (MRSA) otorrhoea; this is a growing concern. The purpose of this study was to evaluate the efficacy of topical vancomycin treatment in patients with MRSA otorrhoea. Fifty-five patients with MRSA otorrhoea were prospectively enrolled into the study. Thirty-five patients were treated with vancomycin eardrops as outpatients. The concentration of the locally prepared vancomycin solution was 25 mg/ml. The dose of vancomycin was two drops three times daily for 10 days. As a control group, 20 patients were treated with gentamicin 0.3% solution. Data were analysed by the Mann-Whitney U test to compare the efficacy of vancomycin eardrops and gentamicin eardrops. In the vancomycin group, the otorrhoea was significantly reduced in 33 ears (94%); in the gentamicin group, in four ears (20 per cent); this reduction was statistically significant (P < 0.03). The use of topical vancomycin treatment was effective for patients with MRSA otorrhoea refractory to conventional antibiotic treatment.

Type
Research Article
Copyright
© 2004 Royal Society of Medicine Press