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Spindle cell carcinoma arising in the pharynx, with granulocytosis and high serum granulocyte colony stimulating factor titre

Published online by Cambridge University Press:  06 December 2006

R Kanayama ,
K Oka ,
M Fukunaga ,
H Tomisawa ,
Y Takahashi ,
M Okano  and
H Hakozaki
R Kanayama
Affiliation:
Department of Otorhinopharyngolaryngology, Mito Saiseikai General Hospital, Mito, Ibaraki, Japan
K Oka
Affiliation:
Department of Pathology, Mito Saiseikai General Hospital, Mito, Ibaraki, Japan
M Fukunaga
Affiliation:
Department of Pathology, Jikei University School of Medicine, Daisan Hospital, Komaeshi, Tokyo, Japan
H Tomisawa
Affiliation:
Department of Otorhinopharyngolaryngology, Mito Saiseikai General Hospital, Mito, Ibaraki, Japan
Y Takahashi
Affiliation:
Department of Otorhinopharyngolaryngology, Mito Saiseikai General Hospital, Mito, Ibaraki, Japan
M Okano
Affiliation:
Department of Pathology, Mito Saiseikai General Hospital, Mito, Ibaraki, Japan
H Hakozaki
Affiliation:
Department of Pathology, Fukushima Rosai Hospital, Iwaki, Fukushima, Japan.
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Abstract

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We report the case of a 67-year-old man with a left pharyngeal tumour, whose peripheral blood showed granulocytosis (white blood cell count, 58 300/μl) and a high serum granulocyte colony stimulating factor titre (184 pg/ml). The tumour showed pleomorphic proliferation of atypical spindle cells in a myxomatous stroma, revealing a sarcomatous pattern. The spindle-shaped neoplastic cells had irregularly shaped nuclei, a thick nuclear membrane, prominent eosinophilic nucleoli and abundant cytoplasm. They strongly expressed wide-spectrum keratin, cytokeratins (CAM5.2, MNF116), vimentin and vascular endothelial growth factor. A few neoplastic cells expressed granulocyte colony stimulating factor. A spindle cell carcinoma was diagnosed. This may be the first documented case of a granulocyte colony stimulating factor producing cancer arising in the pharynx. The patient died four months after the initial symptoms appeared.

Keywords

PharynxSpindle Cell CarcinomaGranulocyte Colony Stimulating Factor
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 121 , Issue 6 , June 2007 , pp. 597 - 600
Copyright
2007 JLO (1984) Limited